2014
TLR‐mediated STAT3 and ERK activation controls IL‐10 secretion by human B cells
Liu B, Cao Y, Huizinga TW, Hafler DA, Toes RE. TLR‐mediated STAT3 and ERK activation controls IL‐10 secretion by human B cells. European Journal Of Immunology 2014, 44: 2121-2129. PMID: 24737107, DOI: 10.1002/eji.201344341.Peer-Reviewed Original ResearchConceptsIL-10 productionIL-10-producing B cellsB cellsHuman B cellsIL-10IL-10 secretionPotent immunoregulatory cytokineType I IFNERK activationType I IFN familyInhibition of STAT3TLR-MyD88Activation of STAT3Immunoregulatory cytokinesTLR signalingPotent productionMouse modelI IFNCD40 ligationAntibody productionTLRSTAT3 pathwayIFNIFN familyPotential target
2001
Immunological Memory: Contribution of Memory B Cells Expressing Costimulatory Molecules in the Resting State
Bar-Or A, Oliveira E, Anderson D, Krieger J, Duddy M, O’Connor K, Hafler D. Immunological Memory: Contribution of Memory B Cells Expressing Costimulatory Molecules in the Resting State. The Journal Of Immunology 2001, 167: 5669-5677. PMID: 11698439, DOI: 10.4049/jimmunol.167.10.5669.Peer-Reviewed Original ResearchConceptsMemory B cellsB cell subsetsB cellsCell subsetsCostimulatory moleculesB cell memory compartmentMemory responsesImmune memory responseDistinct B cell subsetsHuman memory B cellsHumoral memory responsesHuman B cellsTh cellsImmunological memoryT cellsMemory compartmentPoor APCsMurine systemNovel subpopulationRelative paucityCells