1992
Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions.
Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML, Hafler DA. Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 4588-4592. PMID: 1374907, PMCID: PMC49128, DOI: 10.1073/pnas.89.10.4588.Peer-Reviewed Original ResearchConceptsGamma delta T cellsDelta T cellsT cellsMultiple sclerosisMS plaquesCentral nervous system inflammatory processesAcute multiple sclerosis lesionsT cell receptor repertoireGamma delta T-cell receptor repertoireHeat shock proteinsAcute MS plaquesMS plaque tissueNormal CNS tissueDistinct lymphocyte populationsT cell populationsMultiple sclerosis lesionsShock proteinsAcute plaquesReactive astrocytesLymphocyte populationsInflammatory processFoamy macrophagesCNS tissueInflammatory sitesQuantitative immunohistochemistry
1986
Antigen reactive memory T cells are defined by Ta1.
Hafler DA, Fox DA, Benjamin D, Weiner HL. Antigen reactive memory T cells are defined by Ta1. The Journal Of Immunology 1986, 137: 414-8. PMID: 3013990, DOI: 10.4049/jimmunol.137.2.414.Peer-Reviewed Original ResearchConceptsT cellsReactive memory T cellsPeripheral blood T cellsAutologous mixed lymphocyte responseHuman peripheral blood T cellsMemory T cellsMixed lymphocyte responseBlood T cellsPresence of PWMT cell clonesEnhanced proliferative responseTA1 cellsActivated T cellsNormal human subjectsT cell linesT memory cellsSuppressor cellsLymphocyte responsesAnamnestic responseMitogen PHAPeripheral bloodLymphocyte populationsIL-2Tetanus toxoidT lymphocytes