2013
Protein array–based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis
Querol L, Clark PL, Bailey MA, Cotsapas C, Cross AH, Hafler DA, Kleinstein SH, Lee JY, Yaari G, Willis SN, O'Connor KC. Protein array–based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis. Neurology 2013, 81: 956-963. PMID: 23921886, PMCID: PMC3888197, DOI: 10.1212/wnl.0b013e3182a43b48.Peer-Reviewed Original ResearchConceptsCSF of patientsMultiple sclerosisNeurologic diseaseEpstein-Barr virus infectionImmunoglobulin GElevated immunoglobulin GInflammatory neurologic diseasesSubset of patientsLarger validation cohortRecombination signal binding proteinImmunoglobulin kappa J regionCSF autoantibodiesValidation cohortControl subjectsSerum reactivityAutoantigen candidatesHigh prevalenceVirus infectionPatientsAutoantibodiesCSFSclerosisArray-based profilingDiseaseELISA
2007
New Therapeutic Approaches for Multiple Sclerosis
De Jager PL, Hafler DA. New Therapeutic Approaches for Multiple Sclerosis. Annual Review Of Medicine 2007, 58: 417-432. PMID: 17217332, DOI: 10.1146/annurev.med.58.071105.111552.Peer-Reviewed Original ResearchConceptsCentral nervous systemMultiple sclerosisNeurodegenerative componentImmunology of MSLarge unmet clinical needSubset of patientsUnderlying pathophysiologic processEffective immunomodulatory treatmentsEntry of lymphocytesNew therapeutic approachesUnmet clinical needCategories of diseaseImmunomodulatory treatmentInflammatory componentCurrent therapiesImmune homeostasisImmune responseIndividual patientsPathophysiologic processesTherapeutic approachesTreatment approachesNervous systemPatientsHealthy profileClinical need