Production of Proinflammatory Cytokines by Monocytes in Liver-Transplanted Recipients with De Novo Autoimmune Hepatitis Is Enhanced and Induces TH1-like Regulatory T Cells
Arterbery AS, Osafo-Addo A, Avitzur Y, Ciarleglio M, Deng Y, Lobritto SJ, Martinez M, Hafler DA, Kleinewietfeld M, Ekong UD. Production of Proinflammatory Cytokines by Monocytes in Liver-Transplanted Recipients with De Novo Autoimmune Hepatitis Is Enhanced and Induces TH1-like Regulatory T Cells. The Journal Of Immunology 2016, 196: 4040-4051. PMID: 27183637, PMCID: PMC4874532, DOI: 10.4049/jimmunol.1502276.Peer-Reviewed Original ResearchConceptsRegulatory T cellsIL-12IL-6T cellsSuppressive functionDe novo autoimmune hepatitisHuman regulatory T cellsNovo autoimmune hepatitisProinflammatory IL-12Th17 effector cellsTregs of patientsDifferentiation of TregsIL-17 cytokinesBlockade of IFNMonocyte/macrophage cellsLiver of subjectsAutoimmune hepatitisDominant cytokineProinflammatory IFNTH1-likeIL-17Treg phenotypeTreg dysfunctionEffector cellsInflammatory milieu