2015
Fast Biological Modeling for Voxel-based Heavy Ion Treatment Planning Using the Mechanistic Repair-Misrepair-Fixation Model and Nuclear Fragment Spectra
Kamp F, Cabal G, Mairani A, Parodi K, Wilkens JJ, Carlson DJ. Fast Biological Modeling for Voxel-based Heavy Ion Treatment Planning Using the Mechanistic Repair-Misrepair-Fixation Model and Nuclear Fragment Spectra. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: 557-568. PMID: 26460998, DOI: 10.1016/j.ijrobp.2015.07.2264.Peer-Reviewed Original ResearchConceptsRelative biological effectivenessCarbon ion therapyCarbon ionsIon therapyHeavy ion treatment planningMonte Carlo code FLUKAPrimary carbon ionsCarbon ion energyRadiation therapy beamsRBE valuesCarbon ion treatment plansRelevant RBE valuesRMF predictionsHeavy ionsIon energyDouble-strand break (DSB) yieldsRMF modelEnergy spectrumTherapy beamsSecondary fragmentsMonte Carlo damage simulationNuclear fragmentsBiological optimizationBiological effectivenessRBE predictions
2014
Predicting the Relative Biological Effectiveness of Carbon Ion Radiation Therapy Beams Using the Mechanistic Repair-Misrepair-Fixation (RMF) Model and Nuclear Fragment Spectra
Kamp F, Cabal G, Mairani A, Parodi K, Wilkens J, Carlson D. Predicting the Relative Biological Effectiveness of Carbon Ion Radiation Therapy Beams Using the Mechanistic Repair-Misrepair-Fixation (RMF) Model and Nuclear Fragment Spectra. International Journal Of Radiation Oncology • Biology • Physics 2014, 90: s849. DOI: 10.1016/j.ijrobp.2014.05.2434.Peer-Reviewed Original ResearchRadiation therapy beamsRelative biological effectivenessTherapy beamsBiological effectivenessFragment spectraBeamSpectra
2011
A Mechanism-Based Approach to Predict the Relative Biological Effectiveness of Protons and Carbon Ions in Radiation Therapy
Frese MC, Yu VK, Stewart RD, Carlson DJ. A Mechanism-Based Approach to Predict the Relative Biological Effectiveness of Protons and Carbon Ions in Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2011, 83: 442-450. PMID: 22099045, DOI: 10.1016/j.ijrobp.2011.06.1983.Peer-Reviewed Original ResearchConceptsRelative biological effectivenessCarbon ionsRadiation qualityUniform biological effectIon kinetic energyBiological effectivenessMonte Carlo modelParticle energyRMF modelBragg peakMonte Carlo damage simulation (MCDS) softwareCarlo modelRelevant protonsLinear-quadratic parametersKinetic energyProton relative biological effectivenessProtonsPhysical doseParticle distributionIonsParameter αEnergyRepresentative spreadSOBPPotential biological advantages
2010
Mechanistic Modeling of the Relative Biological Effectiveness of Photon, Proton, and Carbon Ion Radiation Therapy
Carlson D, Stewart R. Mechanistic Modeling of the Relative Biological Effectiveness of Photon, Proton, and Carbon Ion Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2010, 78: s48-s49. DOI: 10.1016/j.ijrobp.2010.07.149.Peer-Reviewed Original Research