2017
Rapid implementation of the repair-misrepair-fixation (RMF) model facilitating online adaption of radiosensitivity parameters in ion therapy
Kamp F, Carlson DJ, Wilkens JJ. Rapid implementation of the repair-misrepair-fixation (RMF) model facilitating online adaption of radiosensitivity parameters in ion therapy. Physics In Medicine And Biology 2017, 62: n285-n296. PMID: 28561011, DOI: 10.1088/1361-6560/aa716b.Peer-Reviewed Original Research
2015
Fast Biological Modeling for Voxel-based Heavy Ion Treatment Planning Using the Mechanistic Repair-Misrepair-Fixation Model and Nuclear Fragment Spectra
Kamp F, Cabal G, Mairani A, Parodi K, Wilkens JJ, Carlson DJ. Fast Biological Modeling for Voxel-based Heavy Ion Treatment Planning Using the Mechanistic Repair-Misrepair-Fixation Model and Nuclear Fragment Spectra. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: 557-568. PMID: 26460998, DOI: 10.1016/j.ijrobp.2015.07.2264.Peer-Reviewed Original ResearchConceptsRelative biological effectivenessCarbon ion therapyCarbon ionsIon therapyHeavy ion treatment planningMonte Carlo code FLUKAPrimary carbon ionsCarbon ion energyRadiation therapy beamsRBE valuesCarbon ion treatment plansRelevant RBE valuesRMF predictionsHeavy ionsIon energyDouble-strand break (DSB) yieldsRMF modelEnergy spectrumTherapy beamsSecondary fragmentsMonte Carlo damage simulationNuclear fragmentsBiological optimizationBiological effectivenessRBE predictions