2010
Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake
Mayne ST, Cartmel B, Scarmo S, Lin H, Leffell DJ, Welch E, Ermakov I, Bhosale P, Bernstein PS, Gellermann W. Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake. American Journal Of Clinical Nutrition 2010, 92: 794-800. PMID: 20685953, PMCID: PMC3133234, DOI: 10.3945/ajcn.2010.29707.Peer-Reviewed Original ResearchConceptsIntraclass correlation coefficientDermal carotenoidsDermal biopsiesRR measuresBiomarkers of fruitDietary carotenoid intakeVegetable intakeCarotenoid statusCarotenoid intakeStudy of nutritionNoninvasive assessmentBiopsyBiomarkersSkin pigmentationTotal carotenoidsHuman skinIntakeWkInner armLycopeneValid methodArmSignificant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adults
Scarmo S, Cartmel B, Lin H, Leffell DJ, Welch E, Bhosale P, Bernstein PS, Mayne ST. Significant correlations of dermal total carotenoids and dermal lycopene with their respective plasma levels in healthy adults. Archives Of Biochemistry And Biophysics 2010, 504: 34-39. PMID: 20637178, PMCID: PMC2957565, DOI: 10.1016/j.abb.2010.07.004.Peer-Reviewed Original ResearchConceptsHuman skin photoprotectionRespective plasma levelsHigh-performance liquid chromatographyHuman skinPlasma levelsBlood samplesHealthy humansHealthy adultsHydrocarbon carotenoidsDermal biopsiesSkin photoprotectionSimilar proportionsSkinSignificant correlationPerformance liquid chromatographyIndividual carotenoid contentTotal carotenoidsRelative levelsLycopeneLiquid chromatographyBiopsyPlasmaLutein
1996
Frequent clones of p53-mutated keratinocytes in normal human skin
Jonason A, Kunala S, Price G, Restifo R, Spinelli H, Persing J, Leffell D, Tarone R, Brash D. Frequent clones of p53-mutated keratinocytes in normal human skin. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 14025-14029. PMID: 8943054, PMCID: PMC19488, DOI: 10.1073/pnas.93.24.14025.Peer-Reviewed Original ResearchConceptsP53-mutated keratinocytesNormal individualsSun-shielded skinSun-exposed skinNormal human skinHuman skinWhole-mount preparationsP53-mutated cellsCancer predictsDermal-epidermal junctionSubstantial burdenFrequent clonesClonal expansionHair folliclesGenetic hitsTumor promoterSkinKeratinocytesCells
1989
In Vivo Fluorescence of Human Skin-Reply
Leffell D, Stetz M, Milstone L, Deckelbaum L. In Vivo Fluorescence of Human Skin-Reply. JAMA Dermatology 1989, 125: 999-1000. DOI: 10.1001/archderm.1989.01670190133021.Peer-Reviewed Original Research