2020
Predicting outcomes following second intent healing of periocular surgical defects
Kibbi N, Khan Y, Leffell DJ, Christensen SR, Suozzi KC. Predicting outcomes following second intent healing of periocular surgical defects. Archives Of Dermatological Research 2020, 313: 483-489. PMID: 32833078, DOI: 10.1007/s00403-020-02122-w.Peer-Reviewed Original ResearchConceptsMohs micrographic surgeryMedial canthusSingle academic surgical centerAcademic surgical centerConclusionsThis retrospective studyMedial canthal lesionAverage defect diameterMethodsRetrospective analysisTumor characteristicsPeriocular tumorsRetrospective studyPoor outcomePeriocular lesionsSurgical centersMicrographic surgeryWorse outcomesAnatomic locationAimThe purposeScar outcomeLarge lesionsUpper eyelidEyelid marginLid marginSurgical defectsLower eyelid
2017
Emerging concepts and recent advances in basal cell carcinoma
Totonchy M, Leffell D. Emerging concepts and recent advances in basal cell carcinoma. F1000Research 2017, 6: 2085. PMID: 29259776, PMCID: PMC5717469, DOI: 10.12688/f1000research.11314.1.Peer-Reviewed Original ResearchBasal cell carcinomaTreatment of BCCCell carcinomaIncidence of BCCNon-keratinizing cellsHigh cure ratesNon-surgical interventionsNon-surgical approachStandard of careMohs micrographic surgeryTargeted molecular therapiesRecurrent diseaseSurgical excisionCommon malignancySurgical interventionCure rateMicrographic surgeryMolecular therapyCarcinomaBasal layerTreatmentBurden of managementInterventionMorbiditySurgery
2015
Histopathologic assessment of depth of follicular invasion of squamous cell carcinoma (SCC) in situ (SCCis): Implications for treatment approach
Christensen SR, McNiff JM, Cool AJ, Aasi SZ, Hanlon AM, Leffell DJ. Histopathologic assessment of depth of follicular invasion of squamous cell carcinoma (SCC) in situ (SCCis): Implications for treatment approach. Journal Of The American Academy Of Dermatology 2015, 74: 356-362. PMID: 26670714, DOI: 10.1016/j.jaad.2015.09.060.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaHair follicle infundibulumFollicular invasionCell carcinomaMohs micrographic surgeryHair follicle epitheliumAdditional patientsIntraoperative pathologyOptimal therapyRetrospective reviewTreatment failureProspective evaluationSingle institutionHistopathologic assessmentMicrographic surgeryMost tumorsDeep invasionTreatment approachesPathology specimensFollicle epitheliumLower follicleSCCISSurgeryCarcinomaInvasionFast Absorbing Gut Suture versus Cyanoacrylate Tissue Adhesive in the Epidermal Closure of Linear Repairs Following Mohs Micrographic Surgery.
Kim J, Singh Maan H, Cool AJ, Hanlon AM, Leffell DJ. Fast Absorbing Gut Suture versus Cyanoacrylate Tissue Adhesive in the Epidermal Closure of Linear Repairs Following Mohs Micrographic Surgery. The Journal Of Clinical And Aesthetic Dermatology 2015, 8: 24-9. PMID: 25741400, PMCID: PMC4345930.Peer-Reviewed Original ResearchMohs micrographic surgeryMicrographic surgeryCyanoacrylate tissue adhesiveGut sutureCosmetic outcomeFacial woundsThree-month postoperative visitLinear repairEpidermal closureTopical adhesiveComparable aesthetic outcomesOverall cosmetic outcomeMajority of patientsSatisfactory surgical outcomesNonmelanoma skin cancerAdditional patient visitsTissue adhesiveClosure techniqueWound closure methodsWound closure techniquesPostoperative visitSurgical outcomesWound lengthHead studiesContralateral side
2010
Squamoid Eccrine Ductal Carcinoma: A Case Report and Review of the Literature
Terushkin E, Leffell DJ, Futoryan T, Cowper S, Lazova R. Squamoid Eccrine Ductal Carcinoma: A Case Report and Review of the Literature. American Journal Of Dermatopathology 2010, 32: 287-292. PMID: 20010402, DOI: 10.1097/dad.0b013e3181b623c4.Peer-Reviewed Case Reports and Technical NotesConceptsDuctal carcinomaShave biopsyEccrine ductal carcinomaInitial shave biopsySuperficial shave biopsiesMohs micrographic surgeryRare adnexal tumorTreatment guidelinesCase reportDiagnostic challengeMicrographic surgeryBiologic behaviorComplete excisionAdnexal tumorsImmunohistochemical approachBiopsyCarcinomaRare variantsTumorsDiagnostic purposesPatientsSurgeryNeoplasmsExcisionCancer
2009
Mohs micrographic surgery histopathology concordance
Mariwalla K, Aasi SZ, Glusac EJ, Leffell DJ. Mohs micrographic surgery histopathology concordance. Journal Of The American Academy Of Dermatology 2009, 60: 94-98. PMID: 19103361, PMCID: PMC2632938, DOI: 10.1016/j.jaad.2008.09.061.Peer-Reviewed Original Research
2007
Management of nonmelanoma skin cancer in 2007
Neville JA, Welch E, Leffell DJ. Management of nonmelanoma skin cancer in 2007. Nature Reviews Clinical Oncology 2007, 4: 462-469. PMID: 17657251, DOI: 10.1038/ncponc0883.Peer-Reviewed Original ResearchConceptsNonmelanoma skin cancerSkin cancerNew noninvasive treatmentImmune response modifiersMohs micrographic surgeryTopical chemotherapeuticsSelect tumorsHistological patternMicrographic surgerySurgical methodsConventional excisionNoninvasive optionNoninvasive treatmentTumor typesSurgeryCancerPhotodynamic therapyTreatmentCurettageMorbidityElectrodesiccationTherapyTumorsExcisionRetinoids
2005
Mohs micrographic surgery: established uses and emerging trends.
Pennington BE, Leffell DJ. Mohs micrographic surgery: established uses and emerging trends. Oncology 2005, 19: 1165-71; discussion 1171-2, 1175. PMID: 16255133.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaBasal cell carcinomaMohs micrographic surgeryCell carcinomaMicrographic surgeryCommon cutaneous neoplasmsConventional surgical excisionExtramammary Paget's diseaseMicrocystic adnexal carcinomaMerkel cell carcinomaCutaneous neoplasmsPaget's diseaseResidual tumorSurgical excisionAdnexal carcinomaCommon cancerCutaneous tumorsSurgical techniqueDermatofibrosarcoma protuberansCarcinomaDeep marginTissue conservationSurgeryTumorsDisease
2002
Human Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic Surgery
CARUCCI J, KOLENIK S, LEFFELL D. Human Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic Surgery. Dermatologic Surgery 2002, 28: 340-343. DOI: 10.1097/00042728-200204000-00008.Peer-Reviewed Original ResearchHuman cadaveric allograftMohs micrographic surgeryBasal cell carcinomaCadaveric allograftsCell carcinomaMicrographic surgeryHealing timeSkin cancerInfiltrative basal cell carcinomaNasal defectsAverage healing timeWound infectionHypergranulation tissueCancer histologyImmediate reconstructionResults FiveMedical statusPatientsExtensive proceduresUseful alternativeAllograftsSurgeryCarcinomaCosmesisCancerHuman Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic Surgery
Carucci JA, Kolenik SA, Leffell DJ. Human Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic Surgery. Dermatologic Surgery 2002, 28: 340-343. PMID: 11966793, DOI: 10.1046/j.1524-4725.2002.01143.x.Peer-Reviewed Original ResearchConceptsHuman cadaveric allograftMohs micrographic surgeryBasal cell carcinomaCadaveric allograftsCell carcinomaMicrographic surgeryHealing timeSkin cancerInfiltrative basal cell carcinomaNasal defectsAverage healing timeWound infectionHypergranulation tissueCancer histologyImmediate reconstructionMedical statusPatientsExtensive proceduresUseful alternativeAllograftsSurgeryCarcinomaCosmesisCancerDefect size
1999
Status of residual tumor in patients with squamous cell carcinoma referred for Mohs micrographic surgery.
McGovern T, Grossman D, Fitzgerald D, Glusac E, Leffell D. Status of residual tumor in patients with squamous cell carcinoma referred for Mohs micrographic surgery. JAMA Dermatology 1999, 135: 1557-9. PMID: 10606080, DOI: 10.1001/archderm.135.12.1557.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaMohs micrographic surgeryResidual tumorCell carcinomaMicrographic surgeryPatientsSurgeryCarcinomaTumorsUse of a Lyophilized Bovine Collagen Matrix in Postoperative Wound Healing
Kolenik S, McGovern T, Leffell D. Use of a Lyophilized Bovine Collagen Matrix in Postoperative Wound Healing. Dermatologic Surgery 1999, 25: 303-307. PMID: 10417587, DOI: 10.1046/j.1524-4725.1999.08230.x.Peer-Reviewed Original ResearchConceptsMohs micrographic surgeryBovine collagen matrixMicrographic surgeryWound careControl groupWound healingMinority of patientsPostoperative wound healingSecond intention healingCollagen matrixManagement of defectsWound infectionDressing changesAdverse reactionsImmediate reconstructionAllergic reactionsComplete healingAnatomic sitesRapid wound healingSurgical defectsStudy woundsLarger studySecond intentionBiological dressingSurgery
1991
An educational device for Mohs micrographic surgery. A three-dimensional model of basal cell carcinoma.
Leffell D. An educational device for Mohs micrographic surgery. A three-dimensional model of basal cell carcinoma. Dermatologic Surgery 1991, 17: 498-501. PMID: 2040753.Peer-Reviewed Original Research