2016
Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity
Munday WR, Leffell DJ, McNiff JM, Ko CJ. Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity. Journal Of Cutaneous Pathology 2016, 43: 759-765. PMID: 27220356, DOI: 10.1111/cup.12738.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaMultiple squamous cell carcinomasCutaneous squamous cell carcinomaHistopathologic featuresCell carcinomaLower extremitiesMultiple cutaneous squamous cell carcinomasRetrospective chart reviewAmerican Joint CommitteeCancer staging criteriaDistinct clinical subtypesChart reviewPerineural invasionActinic keratosisStaging criteriaClinical subtypesMost lesionsStage IJoint CommitteeStage IIKeratoacanthomaPatientsCarcinomaTumorsSubtypes
2015
Melanoma in situ Part II. Histopathology, treatment, and clinical management
Higgins HW, Lee KC, Galan A, Leffell DJ. Melanoma in situ Part II. Histopathology, treatment, and clinical management. Journal Of The American Academy Of Dermatology 2015, 73: 193-203. PMID: 26183968, DOI: 10.1016/j.jaad.2015.03.057.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, TopicalAminoquinolinesBiopsy, NeedleCarcinoma in SituFemaleHumansImiquimodImmunohistochemistryImmunotherapyInjections, IntralesionalInterferon-alphaLaser TherapyMaleMelanomaMohs SurgeryNeoplasm InvasivenessNeoplasm StagingPrognosisRandomized Controlled Trials as TopicSkin NeoplasmsTreatment Outcome
2013
Cutaneous squamous cell carcinomas of the lower extremity: A distinct subset of squamous cell carcinomas
Kim C, Ko CJ, Leffell DJ. Cutaneous squamous cell carcinomas of the lower extremity: A distinct subset of squamous cell carcinomas. Journal Of The American Academy Of Dermatology 2013, 70: 70-74. PMID: 24210370, DOI: 10.1016/j.jaad.2013.09.026.Peer-Reviewed Original ResearchConceptsCutaneous squamous cell carcinomaSquamous cell carcinomaLower extremitiesCell carcinomaClinical featuresIncidence of SCCPrevalence of SCCDistinct subsetsDistinctive clinical featuresNumber of patientsBasal cell carcinomaClinical outcomesSquamous cellsBiologic behaviorSame patientGeneral populationPatientsCarcinomaStudy periodAdditional studiesDefinitive conclusionsIncidenceExtremitiesOutcomesTreatment
2012
Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases
Jedrych J, Leffell D, McNiff JM. Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases. Journal Of Cutaneous Pathology 2012, 39: 317-323. PMID: 22335590, DOI: 10.1111/j.1600-0560.2012.01876.x.Peer-Reviewed Original ResearchConceptsDesmoplastic trichoepitheliomaPerineural involvementDesmoplastic stromaMicrocystic adnexal carcinomaBasal cell carcinomaBenign epithelial proliferationsP75 neurotrophin receptorMiddle-aged womenBenign follicular tumorsCK20-positive cellsSmall dermal nervesAdnexal carcinomaCell carcinomaTumor recurrenceTypical presentationBasaloid epitheliumDermal nervesPerineural spaceNeurotrophin receptorBasaloid cellsEpithelial proliferationDermal proliferationDiffuse expressionFollicular tumorsPatients
2010
Squamoid Eccrine Ductal Carcinoma: A Case Report and Review of the Literature
Terushkin E, Leffell DJ, Futoryan T, Cowper S, Lazova R. Squamoid Eccrine Ductal Carcinoma: A Case Report and Review of the Literature. American Journal Of Dermatopathology 2010, 32: 287-292. PMID: 20010402, DOI: 10.1097/dad.0b013e3181b623c4.Peer-Reviewed Case Reports and Technical NotesConceptsDuctal carcinomaShave biopsyEccrine ductal carcinomaInitial shave biopsySuperficial shave biopsiesMohs micrographic surgeryRare adnexal tumorTreatment guidelinesCase reportDiagnostic challengeMicrographic surgeryBiologic behaviorComplete excisionAdnexal tumorsImmunohistochemical approachBiopsyCarcinomaRare variantsTumorsDiagnostic purposesPatientsSurgeryNeoplasmsExcisionCancer
2008
Free Margin Distortion
Aasi S, Leffell D. Free Margin Distortion. 2008, 95-114. DOI: 10.1007/978-0-387-73152-0_9.Peer-Reviewed Original Research
2002
Human Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic Surgery
CARUCCI J, KOLENIK S, LEFFELL D. Human Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic Surgery. Dermatologic Surgery 2002, 28: 340-343. DOI: 10.1097/00042728-200204000-00008.Peer-Reviewed Original ResearchHuman cadaveric allograftMohs micrographic surgeryBasal cell carcinomaCadaveric allograftsCell carcinomaMicrographic surgeryHealing timeSkin cancerInfiltrative basal cell carcinomaNasal defectsAverage healing timeWound infectionHypergranulation tissueCancer histologyImmediate reconstructionResults FiveMedical statusPatientsExtensive proceduresUseful alternativeAllograftsSurgeryCarcinomaCosmesisCancerHuman Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic Surgery
Carucci JA, Kolenik SA, Leffell DJ. Human Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic Surgery. Dermatologic Surgery 2002, 28: 340-343. PMID: 11966793, DOI: 10.1046/j.1524-4725.2002.01143.x.Peer-Reviewed Original ResearchConceptsHuman cadaveric allograftMohs micrographic surgeryBasal cell carcinomaCadaveric allograftsCell carcinomaMicrographic surgeryHealing timeSkin cancerInfiltrative basal cell carcinomaNasal defectsAverage healing timeWound infectionHypergranulation tissueCancer histologyImmediate reconstructionMedical statusPatientsExtensive proceduresUseful alternativeAllograftsSurgeryCarcinomaCosmesisCancerDefect size
2001
Common Benign and Malignant Skin Lesions
Asgari M, Leffell D. Common Benign and Malignant Skin Lesions. 2001, 867-884. DOI: 10.1007/978-1-4757-3432-4_61.Peer-Reviewed Original Research
2000
Electrosurgical Facial Resurfacing: A Prospective Multicenter Study of Efficacy and Safety
Grekin R, Tope W, Yarborough J, Olhoffer I, Lee P, Leffell D, Zachary C. Electrosurgical Facial Resurfacing: A Prospective Multicenter Study of Efficacy and Safety. JAMA Dermatology 2000, 136: 1309-1316. PMID: 11074690, DOI: 10.1001/archderm.136.11.1309.Peer-Reviewed Original ResearchConceptsDermatologic surgery clinicProspective multicenter studySevere postoperative morbidityLower radiofrequency energyTransient postinflammatory hyperpigmentationPostoperative morbidityNoncomparative studySurgery clinicMulticenter studyUntoward effectsAnatomic sitesEffective modalityMean improvementPerioral sitesCosmetic improvementWrinkle improvementHypertrophic scarsPostinflammatory hyperpigmentationPatientsStudy settingClass IFacial skinSevere wrinklesFacial wrinklesIncreased numberIntralesional interferon alfa for treatment of recurrent lentigo maligna of the eyelid in a patient with primary acquired melanosis.
Carucci J, Leffell D. Intralesional interferon alfa for treatment of recurrent lentigo maligna of the eyelid in a patient with primary acquired melanosis. JAMA Dermatology 2000, 136: 1415-6. PMID: 11074712, DOI: 10.1001/archderm.136.11.1415.Peer-Reviewed Original Research
1999
Status of residual tumor in patients with squamous cell carcinoma referred for Mohs micrographic surgery.
McGovern T, Grossman D, Fitzgerald D, Glusac E, Leffell D. Status of residual tumor in patients with squamous cell carcinoma referred for Mohs micrographic surgery. JAMA Dermatology 1999, 135: 1557-9. PMID: 10606080, DOI: 10.1001/archderm.135.12.1557.Peer-Reviewed Original Research
1995
The Use of Cryopreserved Human Skin Allografts in Wound Healing following Mohs Surgery
KOLENIK S, LEFFELL D. The Use of Cryopreserved Human Skin Allografts in Wound Healing following Mohs Surgery. Dermatologic Surgery 1995, 21: 615-620. PMID: 7606373, DOI: 10.1111/j.1524-4725.1995.tb00517.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoma, Basal CellCarcinoma, Squamous CellCryopreservationDermatologic Surgical ProceduresFemaleFollow-Up StudiesGraft RejectionGraft SurvivalGranulation TissueHumansMaleMiddle AgedMohs SurgerySkinSkin CareSkin NeoplasmsSkin TransplantationSurgical Wound InfectionTransplantation, HomologousTreatment OutcomeWound HealingConceptsHuman skin allograftsWound careSkin allograftsImmediate reconstructionMohs surgeryFull-thickness skin graftingMinority of patientsEvidence of infectionExcision of tumorSkin cancer patientsFull‐thickness cutaneous defectGranulation tissue productionFull-thickness skinCancer patientsSkin graftingReconstructive proceduresWound coverageSafe alternativeBiological dressingCutaneous defectsPatientsRapid healingWound healingHealingCare
1993
The Effect of Pre‐Education on Patient Compliance with Full‐Body Examination in a Public Skin Cancer Screening
LEFFELL D, BERWICK M, BOLOGNIA J. The Effect of Pre‐Education on Patient Compliance with Full‐Body Examination in a Public Skin Cancer Screening. Dermatologic Surgery 1993, 19: 660-663. PMID: 8349904, DOI: 10.1111/j.1524-4725.1993.tb00407.x.Peer-Reviewed Original ResearchConceptsFull-body skin examinationSkin cancer screeningSkin examinationCancer screeningGenital examSun-exposed areasFull-body examinationPre educationGroup BFormer patientsGroup AGenital examinationPatient compliancePatientsPatient resistanceEarly melanomaComplete examinationExaminationDecreases concernScreeningStandardized proceduresExamSame sexPositive attitudesMelanoma
1991
Aggressive-Growth Basal Cell Carcinoma in Young Adults
Leffell DJ, Headington JT, Wong DS, Swanson NA. Aggressive-Growth Basal Cell Carcinoma in Young Adults. JAMA Dermatology 1991, 127: 1663-1667. PMID: 1952969, DOI: 10.1001/archderm.1991.01680100063005.Peer-Reviewed Original ResearchConceptsAggressive-growth basal cell carcinomaYears of ageBasal cell carcinomaOlder age groupsCell carcinomaGreater long-term morbidityAge groupsLong-term morbidityBasal cell cancerRecurrent BCCCell cancerPathologic findingsRetrospective studyTypes of BCCMohs surgeryClinical observationsPatientsInadequate treatmentYoung adultsAgeCarcinomaWomenMenGroupYears