2019
Squamous Cell Carcinoma of the Lip in a Patient With Graft-Versus-Host Disease
Kibbi N, Suozzi KC, Ko CJ, Leffell DJ. Squamous Cell Carcinoma of the Lip in a Patient With Graft-Versus-Host Disease. Dermatologic Surgery 2019, Publish Ahead of Print: &na;. PMID: 31260417, DOI: 10.1097/dss.0000000000001706.Peer-Reviewed Original Research
2017
Cross-sectional assessment of ultraviolet radiation–related behaviors among young people after a diagnosis of melanoma or basal cell carcinoma
Ferrucci LM, Cartmel B, Clare RA, Choy CC, Kershaw T, Leffell DJ, Mayne ST. Cross-sectional assessment of ultraviolet radiation–related behaviors among young people after a diagnosis of melanoma or basal cell carcinoma. Journal Of The American Academy Of Dermatology 2017, 79: 149-152. PMID: 29291957, PMCID: PMC6004335, DOI: 10.1016/j.jaad.2017.12.056.Peer-Reviewed Original ResearchPredictors of tanning dependence in white non‐Hispanic females and males
Cartmel B, Bale AE, Mayne ST, Gelernter JE, DeWan AT, Spain P, Leffell DJ, Pagoto S, Ferrucci LM. Predictors of tanning dependence in white non‐Hispanic females and males. Journal Of The European Academy Of Dermatology And Venereology 2017, 31: 1223-1228. PMID: 28129487, PMCID: PMC5522341, DOI: 10.1111/jdv.14138.Peer-Reviewed Original ResearchConceptsEarly-onset basal cell carcinomaCase-control studyBasal cell carcinomaWhite non-Hispanic femalesSymptoms of dependenceCell carcinomaNon-Hispanic femalesAlcohol dependenceMental disordersAppropriate interventionsHost factorsNon-HispanicsStatistical ManualMultivariate modelIndoor tanningSignificant predictorsOnline surveyFourth EditionPredictorsEuropean ancestryQuestionnaireEye openerEye colorParticipantsCarcinoma
2016
Body mass index, height and early-onset basal cell carcinoma in a case-control study
Zhang Y, Cartmel B, Choy CC, Molinaro AM, Leffell DJ, Bale AE, Mayne ST, Ferrucci LM. Body mass index, height and early-onset basal cell carcinoma in a case-control study. Cancer Epidemiology 2016, 46: 66-72. PMID: 28039770, PMCID: PMC5272867, DOI: 10.1016/j.canep.2016.12.007.Peer-Reviewed Original ResearchConceptsEarly-onset basal cell carcinomaBody mass indexBasal cell carcinomaMass indexCell carcinomaInverse associationOdds ratioAdult heightUnconditional logistic regression modelsAdult body mass indexBenign skin conditionsMultivariate odds ratiosSimilar inverse associationsConfidence intervalsCase-control studySignificant inverse associationLogistic regression modelsUltraviolet radiation exposurePrior UV exposureCommon malignancyControl subjectsUV exposureBiopsy siteMedical characteristicsSkin conditions
2015
Family history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotype
Berlin NL, Cartmel B, Leffell DJ, Bale AE, Mayne ST, Ferrucci LM. Family history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotype. Cancer Epidemiology 2015, 39: 1078-1083. PMID: 26381319, PMCID: PMC4679454, DOI: 10.1016/j.canep.2015.09.005.Peer-Reviewed Original ResearchConceptsEarly-onset basal cell carcinomaBasal cell carcinomaFamily historySkin cancerAge of onsetLifestyle factorsBenign skin conditionsStrong risk factorFirst-degree relativesMC1R genotypeCell carcinomaRisk factorsAge 40High riskLifestyle characteristicsAge 50Particular malignancySkin conditionsBCC casesCancerGenetic susceptibilitySaliva samplesMultivariate modelIndividual riskAffected relativesSubsequent skin cancer in patients with early‐onset basal cell carcinoma
Berlin NL, Ferrucci LM, Cartmel B, Wang SY, Leffell DJ, McNiff JM, Mayne ST. Subsequent skin cancer in patients with early‐onset basal cell carcinoma. Australasian Journal Of Dermatology 2015, 56: 236-237. PMID: 26201376, DOI: 10.1111/ajd.12338.Peer-Reviewed Original ResearchIndoor Tanning and the MC1R Genotype: Risk Prediction for Basal Cell Carcinoma Risk in Young People
Molinaro AM, Ferrucci LM, Cartmel B, Loftfield E, Leffell DJ, Bale AE, Mayne ST. Indoor Tanning and the MC1R Genotype: Risk Prediction for Basal Cell Carcinoma Risk in Young People. American Journal Of Epidemiology 2015, 181: 908-916. PMID: 25858289, PMCID: PMC4445390, DOI: 10.1093/aje/kwu356.Peer-Reviewed Original ResearchConceptsRisk prediction modelCancer risk prediction modelsIndoor tanningBasal cell carcinoma incidenceBasal cell carcinoma riskNovel risk prediction modelRisk of BCCRisk predictionCase-control studyNon-Hispanic whitesLogistic regression modelsCancer risk predictionSignificant morbidityCarcinoma incidenceAdjusted areaCarcinoma riskIndependent cohortYoung individualsTreatment costsMC1R variantsYoung peopleReceptor geneCharacteristic curveA Strategy for the Successful Management of Dermatofibrosarcoma Protuberans
Goldberg C, Hoang D, McRae M, Chung C, Leffell DJ, Narayan D. A Strategy for the Successful Management of Dermatofibrosarcoma Protuberans. Annals Of Plastic Surgery 2015, 74: 80-84. PMID: 23788146, DOI: 10.1097/sap.0b013e3182898692.Peer-Reviewed Original ResearchConceptsSurgical excisionPositive marginsDermatofibrosarcoma protuberansMohs surgeryNational Comprehensive Cancer Network guidelinesDisease recurrence/persistenceMargin sizeClear histological marginsComplications of reconstructionInitial surgical resectionRecurrence/persistenceTraditional surgical excisionSoft tissue sarcomasMethod of treatmentExcision patientsHistological marginsSurgery groupSubclinical involvementSurgical resectionMargin statusDistant metastasisNetwork guidelinesTissue sarcomasClinical variablesTumor resection
2014
Mesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing in vivo
Mendez JJ, Ghaedi M, Sivarapatna A, Dimitrievska S, Shao Z, Osuji CO, Steinbacher DM, Leffell DJ, Niklason LE. Mesenchymal stromal cells form vascular tubes when placed in fibrin sealant and accelerate wound healing in vivo. Biomaterials 2014, 40: 61-71. PMID: 25433608, PMCID: PMC4268422, DOI: 10.1016/j.biomaterials.2014.11.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsBiomarkersCollagenDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFemaleFibrin Tissue AdhesiveFibroblast Growth Factor 2Flow CytometryHumansImmunohistochemistryMaleMesenchymal Stem CellsMice, Inbred C57BLMiddle AgedNeovascularization, PhysiologicReal-Time Polymerase Chain ReactionRheologySubcutaneous TissueWound HealingConceptsAdipose-derived mesenchymal stromal cellsMesenchymal stromal cellsGranulation tissueStromal cellsPericyte marker NG2VE-cadherinWound healingPublic health problemMarkers of endotheliumDays of healingSubcutaneous injectionPresence of bFGFFibrin gelAmount of bFGFHAT-MSCsFibrin sealantWound sizeHealth problemsChronic woundsConfocal imaging analysisInsufficient angiogenesisAlcohol intake and early‐onset basal cell carcinoma in a case–control study
Zhang Y, Ferrucci LM, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST. Alcohol intake and early‐onset basal cell carcinoma in a case–control study. British Journal Of Dermatology 2014, 171: 1451-1457. PMID: 25059635, PMCID: PMC4272627, DOI: 10.1111/bjd.13291.Peer-Reviewed Original ResearchConceptsEarly-onset basal cell carcinomaBasal cell carcinomaLifetime alcohol intakeAlcohol intakeCell carcinomaOdds ratioEpidemiological studiesConfidence intervalsBasal cell carcinoma casesUnconditional multivariate logistic regressionBenign skin conditionsMultivariate logistic regressionOverall alcohol intakeCase-control studyPrevious epidemiological studiesYears of ageType of beverageCarcinoma casesUV exposureHigh riskSkin conditionsSignificant associationLogistic regressionRisk estimatesIntakeTea, coffee, and caffeine and early-onset basal cell carcinoma in a case–control study
Ferrucci LM, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST. Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case–control study. European Journal Of Cancer Prevention 2014, 23: 296-302. PMID: 24841641, PMCID: PMC4059399, DOI: 10.1097/cej.0000000000000037.Peer-Reviewed Original ResearchConceptsEarly-onset basal cell carcinomaBasal cell carcinomaCase-control studyCell carcinomaDermatopathology databaseOdds ratioRegular consumptionRisk of BCCMultivariate odds ratiosSquamous cell carcinomaUnconditional logistic regressionConfidence intervalsModest protective effectHot teaNon-Hispanic whitesPotential health benefitsEpidemiologic evidenceInverse associationProtective effectBiopsy siteAge 40Caffeinated coffeeSkin carcinogenesisBCC casesProtective roleSystemic glucocorticoid use and early-onset basal cell carcinoma
Troche JR, Ferrucci LM, Cartmel B, Leffell DJ, Bale AE, Mayne ST. Systemic glucocorticoid use and early-onset basal cell carcinoma. Annals Of Epidemiology 2014, 24: 625-627. PMID: 24958637, PMCID: PMC4119504, DOI: 10.1016/j.annepidem.2014.05.009.Peer-Reviewed Original Research
2013
Indoor Tanning and Tanning Dependence in Young People After a Diagnosis of Basal Cell Carcinoma
Cartmel B, Ferrucci LM, Spain P, Bale AE, Pagoto SL, Leffell DJ, Gelernter J, Mayne ST. Indoor Tanning and Tanning Dependence in Young People After a Diagnosis of Basal Cell Carcinoma. JAMA Dermatology 2013, 149: 1110-1111. PMID: 23824273, PMCID: PMC3782995, DOI: 10.1001/jamadermatol.2013.5104.Peer-Reviewed Original ResearchSingle v. multiple measures of skin carotenoids by resonance Raman spectroscopy as a biomarker of usual carotenoid status
Scarmo S, Cartmel B, Lin H, Leffell DJ, Ermakov IV, Gellermann W, Bernstein PS, Mayne ST. Single v. multiple measures of skin carotenoids by resonance Raman spectroscopy as a biomarker of usual carotenoid status. British Journal Of Nutrition 2013, 110: 911-917. PMID: 23351238, PMCID: PMC3696054, DOI: 10.1017/s000711451200582x.Peer-Reviewed Original ResearchConceptsSkin carotenoid statusRecent sun exposureCarotenoid statusSkin carotenoidsSun exposureRR measuresFruit/vegetable intakeLower carotenoid statusSeason of measurementMean ageNon-invasive methodVegetable intakeInverse associationDietary dataTime pointsSignificant predictorsMultiple measuresPositive associationIntakeBiomarkersPresent studyStatusPredictorsAssociationExposure
2012
Cutaneous Rosai-Dorfman disease of the right ear responsive to radiotherapy
Bunick CG, Leffell D, Bosenberg M, Yahalom J, Choi JN. Cutaneous Rosai-Dorfman disease of the right ear responsive to radiotherapy. Journal Of The American Academy Of Dermatology 2012, 67: e225-e226. PMID: 23062927, DOI: 10.1016/j.jaad.2012.04.025.Peer-Reviewed Original ResearchDesmoplastic trichoepithelioma with perineural involvement: a series of seven cases
Jedrych J, Leffell D, McNiff JM. Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases. Journal Of Cutaneous Pathology 2012, 39: 317-323. PMID: 22335590, DOI: 10.1111/j.1600-0560.2012.01876.x.Peer-Reviewed Original ResearchConceptsDesmoplastic trichoepitheliomaPerineural involvementDesmoplastic stromaMicrocystic adnexal carcinomaBasal cell carcinomaBenign epithelial proliferationsP75 neurotrophin receptorMiddle-aged womenBenign follicular tumorsCK20-positive cellsSmall dermal nervesAdnexal carcinomaCell carcinomaTumor recurrenceTypical presentationBasaloid epitheliumDermal nervesPerineural spaceNeurotrophin receptorBasaloid cellsEpithelial proliferationDermal proliferationDiffuse expressionFollicular tumorsPatientsLifetime history of indoor tanning in young people: a retrospective assessment of initiation, persistence, and correlates
Lostritto K, Ferrucci LM, Cartmel B, Leffell DJ, Molinaro AM, Bale AE, Mayne ST. Lifetime history of indoor tanning in young people: a retrospective assessment of initiation, persistence, and correlates. BMC Public Health 2012, 12: 118. PMID: 22324969, PMCID: PMC3340300, DOI: 10.1186/1471-2458-12-118.Peer-Reviewed Original Research
2011
Indoor tanning and risk of early-onset basal cell carcinoma
Ferrucci LM, Cartmel B, Molinaro AM, Leffell DJ, Bale AE, Mayne ST. Indoor tanning and risk of early-onset basal cell carcinoma. Journal Of The American Academy Of Dermatology 2011, 67: 552-562. PMID: 22153793, PMCID: PMC3307842, DOI: 10.1016/j.jaad.2011.11.940.Peer-Reviewed Original ResearchConceptsEarly-onset basal cell carcinomaBasal cell carcinomaIndoor tanningCell carcinomaOdds ratioMultiple basal cell carcinomasBenign skin conditionsStrong risk factorConfidence intervalsMultivariate logistic regressionPotential recall biasYears of ageExposure-disease relationshipsIndoor tanning devicesAge of initiationRisk factorsBiopsy siteEpidemiologic studiesSkin conditionsReferent groupControl populationTanning devicesLogistic regressionRecall biasIndoor tannersHost Phenotype Characteristics and MC1R in Relation to Early-Onset Basal Cell Carcinoma
Ferrucci LM, Cartmel B, Molinaro AM, Gordon PB, Leffell DJ, Bale AE, Mayne ST. Host Phenotype Characteristics and MC1R in Relation to Early-Onset Basal Cell Carcinoma. Journal Of Investigative Dermatology 2011, 132: 1272-1279. PMID: 22158557, PMCID: PMC3305835, DOI: 10.1038/jid.2011.402.Peer-Reviewed Original ResearchConceptsDermatopathology databaseSkin reactionsCase statusBasal cell carcinoma incidenceMelanocortin 1 receptor gene variantsNon-synonymous variantsBenign skin conditionsBasal cell carcinomaReceptor gene variantsCarcinoma incidenceCell carcinomaBCC riskEpidemiologic studiesSelf-reported phenotypesLower riskSkin conditionsBCC casesSkin cancerOlder populationYoung individualsGene variantsPhenotype-genotype interactionsHost characteristicsPhenotype characteristicSkin color
2010
Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake
Mayne ST, Cartmel B, Scarmo S, Lin H, Leffell DJ, Welch E, Ermakov I, Bhosale P, Bernstein PS, Gellermann W. Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake. American Journal Of Clinical Nutrition 2010, 92: 794-800. PMID: 20685953, PMCID: PMC3133234, DOI: 10.3945/ajcn.2010.29707.Peer-Reviewed Original ResearchConceptsIntraclass correlation coefficientDermal carotenoidsDermal biopsiesRR measuresBiomarkers of fruitDietary carotenoid intakeVegetable intakeCarotenoid statusCarotenoid intakeStudy of nutritionNoninvasive assessmentBiopsyBiomarkersSkin pigmentationTotal carotenoidsHuman skinIntakeWkInner armLycopeneValid methodArm