2022
Defining textbook outcome for selective internal radiation therapy of hepatocellular carcinoma: an international expert study
Gregory J, Tselikas L, Allimant C, de Baere T, Bargellini I, Bell J, Bilbao JI, Bouvier A, Chapiro J, Chiesa C, Decaens T, Denys A, Duran R, Edeline J, Garin E, Ghelfi J, Helmberger T, Irani F, Lam M, Lewandowski R, Liu D, Loffroy R, Madoff DC, Mastier C, Salem R, Sangro B, Sze D, Vilgrain V, Vouche M, Guiu B, Ronot M. Defining textbook outcome for selective internal radiation therapy of hepatocellular carcinoma: an international expert study. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 50: 921-928. PMID: 36282299, DOI: 10.1007/s00259-022-06002-5.Peer-Reviewed Original ResearchConceptsSelective internal radiation therapyTextbook outcomeInternal radiation therapyHepatocellular carcinomaRadiation therapyPatient-important outcomesLarge observational studiesNuclear medicine physiciansEntire intervention processRandomized trialsRoutine careResultsA totalObservational studyMultistep interventionMedicine physiciansInterventional radiologistsSenior authorClinical roundsCarcinomaTherapyInterventionOutcomes
2021
Balloon-assisted radioembolization via the proper hepatic artery to treat a left liver hepatocellular carcinoma and portal vein tumor thrombus with an inaccessible left hepatic artery: A case report
Mabey JG, Cornman-Homonoff J, Madoff DC. Balloon-assisted radioembolization via the proper hepatic artery to treat a left liver hepatocellular carcinoma and portal vein tumor thrombus with an inaccessible left hepatic artery: A case report. Clinical Imaging 2021, 82: 244-250. PMID: 34920388, DOI: 10.1016/j.clinimag.2021.11.026.Peer-Reviewed Case Reports and Technical NotesConceptsPortal vein tumor thrombusLeft hepatic arteryProper hepatic arteryHepatic arteryVein tumor thrombusHepatocellular carcinomaTransarterial radioembolizationTumor thrombusUse of TAREYttrium-90 transarterial radioembolizationTumor-feeding vesselsLiver hepatocellular carcinomaBalloon occlusionCase reportBalloon microcatheterVessel angulationEffective treatmentLiver parenchymaArteryTumor vesselsY microspheresRadiotracer activityRadioembolizationCarcinomaThrombusConventional Hepatic Volumetry May Lead to Inaccurate Segmental Yttrium-90 Radiation Dosimetry
Stein SI, Soliman MM, Sparapani J, Doustaly R, Cobb BW, Malhotra A, Charalel R, May BJ, Lee KS, Madoff DC, Talenfeld AD. Conventional Hepatic Volumetry May Lead to Inaccurate Segmental Yttrium-90 Radiation Dosimetry. CardioVascular And Interventional Radiology 2021, 44: 1973-1985. PMID: 34414494, DOI: 10.1007/s00270-021-02898-y.Peer-Reviewed Original ResearchMeSH KeywordsEmbolization, TherapeuticHumansLiver NeoplasmsRadiometryRetrospective StudiesYttrium RadioisotopesConceptsMedical Internal Radiation DosimetryCone-beam CTCT/MRI scansSegmental volumesVariant arterial anatomyCT/MRIWilcoxon signed-rank testY90 radioembolizationZone volumeArterial anatomyVenous anatomyTumor locationSigned-rank testInternal radiation dosimetryHepatic volumetryMRI scansLobar volumesVolumetric differencesCouinaudDose targetsPersonalized dosimetryBeam CTAngiogramsDosesVolumetryInternational recommendations for personalised selective internal radiation therapy of primary and metastatic liver diseases with yttrium-90 resin microspheres
Levillain H, Bagni O, Deroose CM, Dieudonné A, Gnesin S, Grosser OS, Kappadath SC, Kennedy A, Kokabi N, Liu DM, Madoff DC, Mahvash A, Martinez de la Cuesta A, Ng DCE, Paprottka PM, Pettinato C, Rodríguez-Fraile M, Salem R, Sangro B, Strigari L, Sze DY, de Wit van der veen BJ, Flamen P. International recommendations for personalised selective internal radiation therapy of primary and metastatic liver diseases with yttrium-90 resin microspheres. European Journal Of Nuclear Medicine And Molecular Imaging 2021, 48: 1570-1584. PMID: 33433699, PMCID: PMC8113219, DOI: 10.1007/s00259-020-05163-5.Peer-Reviewed Original ResearchConceptsSelective internal radiation therapyInternal radiation therapyActivity prescriptionRadiation therapyLiver metastatic colorectal cancerYttrium-90 resin microspheresResin microspheresMetastatic liver diseaseMetastatic colorectal cancerMultidisciplinary expert panelNon-tumoural liverSPECT/CTLiver diseaseColorectal cancerTreatment strategiesHepatocellular carcinomaSteering CommitteePost-treatment dosimetryYttrium-90Multidisciplinary teamTherapeutic intentMicrosphere activityWhole liverLiterature searchLevel of agreement
2017
Update on Embolization Therapies for Hepatocellular Carcinoma
Kishore S, Friedman T, Madoff DC. Update on Embolization Therapies for Hepatocellular Carcinoma. Current Oncology Reports 2017, 19: 40. PMID: 28421483, DOI: 10.1007/s11912-017-0597-2.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, HepatocellularEmbolization, TherapeuticHumansLiverLiver NeoplasmsNeoplasm StagingNiacinamidePhenylurea CompoundsSorafenibYttrium RadioisotopesConceptsEmbolization therapyHepatocellular carcinomaFuture liver remnant hypertrophyPortal vein tumor thrombusPlanned hepatic resectionStage C diseaseBCLC stage AEarly-stage patientsManagement of patientsSafety of resectionVein tumor thrombusRadiation lobectomyRadiation segmentectomyUnresectable HCCUnifocal diseaseHepatic resectionVein embolizationBCLC stageStage patientsSurvival benefitTumor thrombusAblative optionsB diseaseC diseaseDifferent therapies
2016
Clinical implications for imaging of vascular invasion in hepatocellular carcinoma
Baheti AD, Dunham GM, Ingraham CR, Moshiri M, Lall C, Park JO, Li D, Katz DS, Madoff DC, Bhargava P. Clinical implications for imaging of vascular invasion in hepatocellular carcinoma. Abdominal Radiology 2016, 41: 1800-1810. PMID: 27142384, DOI: 10.1007/s00261-016-0763-2.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, HepatocellularEmbolization, TherapeuticHumansLiver NeoplasmsYttrium RadioisotopesConceptsHepatocellular carcinomaVascular invasionManagement of HCCImportant prognostic factorLimited treatment optionsPromising treatment strategyPrognostic factorsTumor thrombusCancer mortalityTreatment optionsPatient managementTreatment strategiesInterventional radiologistsClinical implicationsLargest causeComprehensive updateCarcinomaInvasionRadiologistsThrombusMajor roleMortalityDiagnosis
2008
Yttrium-90 Microsphere Radioembolotherapy of Hepatic Metastatic Neuroendocrine Carcinomas after Hepatic Arterial Embolization
Murthy R, Kamat P, Nunez R, Madoff DC, Gupta S, Salem R, Yao JC. Yttrium-90 Microsphere Radioembolotherapy of Hepatic Metastatic Neuroendocrine Carcinomas after Hepatic Arterial Embolization. Journal Of Vascular And Interventional Radiology 2008, 19: 145-151. PMID: 18192482, DOI: 10.1016/j.jvir.2007.09.006.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngiographyBrachytherapyCarcinoma, NeuroendocrineChemoembolization, TherapeuticFemaleFollow-Up StudiesHumansLiver NeoplasmsMaleMicrospheresMiddle AgedRetrospective StudiesTime FactorsTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedTreatment OutcomeYttrium RadioisotopesConceptsNeuroendocrine hepatic metastasesHepatic metastasesEmbolization proceduresRadiation-induced liver diseaseYttrium-90 resin microspheresMetastatic neuroendocrine carcinomaCohort of patientsHepatic arterial embolizationTime of diagnosisReasonable therapeutic optionMedian survival timeHepatic artery radioembolizationHepatic progressionDisease stabilizationArterial embolizationPartial responseProgressive diseaseMedian ageLiver diseaseTherapeutic optionsStudy criteriaMicrosphere infusionNeuroendocrine carcinomaSurvival timeMicrosphere radioembolization
2007
Hepatic Yttrium-90 Radioembolotherapy in Metastatic Colorectal Cancer Treated with Cetuximab or Bevacizumab
Murthy R, Eng C, Krishnan S, Madoff DC, Habbu A, Canet S, Hicks ME. Hepatic Yttrium-90 Radioembolotherapy in Metastatic Colorectal Cancer Treated with Cetuximab or Bevacizumab. Journal Of Vascular And Interventional Radiology 2007, 18: 1588-1591. PMID: 18057297, DOI: 10.1016/j.jvir.2007.08.015.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngiogenesis InhibitorsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic AgentsBevacizumabCetuximabColorectal NeoplasmsCombined Modality TherapyFemaleHumansLiver NeoplasmsMaleMicrospheresMiddle AgedRadiopharmaceuticalsTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedTreatment OutcomeYttrium RadioisotopesConceptsColorectal cancerTreatment experienceAdvanced unresectable colorectal cancerUnresectable colorectal cancerMetastatic colorectal cancerCohort of patientsYttrium-90 microspheresSystemic therapyBiologic agentsDrug AdministrationHepatic neoplasiaCetuximabPatientsCancerBevacizumabChemotherapyNeoplasiaTherapyCohortPhysiciansAdministration
2005
Yttrium 90 Resin Microspheres for the Treatment of Unresectable Colorectal Hepatic Metastases after Failure of Multiple Chemotherapy Regimens: Preliminary Results
Murthy R, Xiong H, Nunez R, Cohen AC, Barron B, Szklaruk J, Madoff DC, Gupta S, Wallace MJ, Ahrar K, Hicks ME. Yttrium 90 Resin Microspheres for the Treatment of Unresectable Colorectal Hepatic Metastases after Failure of Multiple Chemotherapy Regimens: Preliminary Results. Journal Of Vascular And Interventional Radiology 2005, 16: 937-945. PMID: 16002501, DOI: 10.1097/01.rvi.0000161142.12822.66.Peer-Reviewed Original ResearchConceptsUnresectable colorectal hepatic metastasesColorectal hepatic metastasesHepatic metastasesSIR-SpheresMultiple chemotherapySingle infusionPrescribed doseYttrium-90 resin microspheresEmbolic arterial occlusionHepatic metastatic diseaseMultiple chemotherapy regimensLiver-directed therapiesCarcinoembryonic antigen levelYttrium-90 microspheresCompletion of treatmentMedian survival timeHepatic tumor volumeBilobar diseaseIntrahepatic progressionRadiologic responseUnilobar diseaseAdvanced diseaseChemotherapy regimenChemotherapy regimensIntraarterial chemotherapy