2023
Living Donor Liver Transplantation for Hepatocellular Carcinoma Within and Outside Traditional Selection Criteria
Ivanics T, Claasen M, Samstein B, Emond J, Fox A, Pomfret E, Pomposelli J, Tabrizian P, Florman S, Mehta N, Roberts J, Emamaullee J, Genyk Y, Hernandez-Alejandro R, Tomiyama K, Sasaki K, Hashimoto K, Nagai S, Abouljoud M, Olthoff K, Hoteit M, Heimbach J, Taner T, Liapakis A, Mulligan D, Sapisochin G, Halazun K, Group O. Living Donor Liver Transplantation for Hepatocellular Carcinoma Within and Outside Traditional Selection Criteria. Annals Of Surgery 2023, 279: 104-111. PMID: 37522174, DOI: 10.1097/sla.0000000000006049.Peer-Reviewed Original ResearchConceptsUniversity of California San FranciscoMilan criteriaDonor liver transplantationHepatocellular carcinomaOverall survivalLiver transplantationPosttransplantation survivalEvaluate long-term oncologic outcomesUniversity of California San Francisco criteriaLiving donor liver transplantationRecurrence-free survivalKaplan-Meier methodTransplant selection criteriaProportion of patientsAdult LDLT recipientsNorth American centersLong-term survivalLiver transplant waitlistCalifornia San FranciscoLDLT recipientsMulticenter cohortConsensus guidelinesTransplantationPatientsPosttransplantationLiving donor liver transplant candidate and donor selection and engagement: Meeting report from the living donor liver transplant consensus conference
Jesse M, Jackson W, Liapakis A, Ganesh S, Humar A, Goldaracena N, Levitsky J, Mulligan D, Pomfret E, Ladner D, Roberts J, Mavis A, Thiessen C, Trotter J, Winder G, Griesemer A, Pillai A, Kumar V, Verna E, Rudow D, Han H, Group T. Living donor liver transplant candidate and donor selection and engagement: Meeting report from the living donor liver transplant consensus conference. Clinical Transplantation 2023, 37: e14954. PMID: 36892182, DOI: 10.1111/ctr.14954.Peer-Reviewed Original ResearchConceptsDonor selectionConsensus conferenceDeceased donor organ shortageDonor liver transplantationLiver transplant candidatesDonor organ shortageLiver transplantationTransplant candidatesWaitlist mortalityExcellent outcomesLDLT candidatesOrgan shortageDonation outcomesLack of standardizationAmerican SocietyTransplantationDelphi approachBroad implementationMeeting reportOutcomesCandidate indicationsReportLDLTPatientsBroad uptake
2016
What Every Hepatologist Should Know about Liver Transplantation
Yoo P, Mulligan D. What Every Hepatologist Should Know about Liver Transplantation. 2016, 608-616. DOI: 10.1002/9781119127437.ch93.Peer-Reviewed Original ResearchLiver transplantationPiggyback techniqueExcellent long-term patient outcomesLong-term patient outcomesHepatic venous complicationsRetrohepatic vena cavaDonor liver transplantationLiver transplant patientsRisk of complicationsBiliary complicationsSplit liverTransplant patientsTransplant recipientsVenous complicationsDonor transplantsMultidisciplinary careVena cavaDonor poolPatient outcomesTransplant operationSurgical techniqueOrgan allocationPhysiologic circumstancesComplicationsSuccessful outcome
2012
Endoscopic treatment of anastomotic biliary strictures after living donor liver transplantation: outcomes after maximal stent therapy
Hsieh TH, Mekeel KL, Crowell MD, Nguyen CC, Das A, Aqel BA, Carey EJ, Byrne TJ, Vargas HE, Douglas DD, Mulligan DC, Harrison ME. Endoscopic treatment of anastomotic biliary strictures after living donor liver transplantation: outcomes after maximal stent therapy. Gastrointestinal Endoscopy 2012, 77: 47-54. PMID: 23062758, DOI: 10.1016/j.gie.2012.08.034.Peer-Reviewed Original ResearchMeSH KeywordsAlanine TransaminaseAlkaline PhosphataseAspartate AminotransferasesBiliary Tract DiseasesBilirubinCholangiopancreatography, Endoscopic RetrogradeCholestasisEndoscopy, Digestive SystemFemaleFollow-Up StudiesHumansLiver TransplantationLiving DonorsMalePostoperative ComplicationsRecurrenceRetrospective StudiesStentsTreatment OutcomeConceptsLiving-donor liver transplantationAnastomotic biliary stricturesEndoscopic retrograde cholangiographyPercutaneous transhepatic cholangiographyBiliary stricturesEndoscopic therapyLiver transplantationEndoscopic treatmentRetrograde cholangiographySurgical revisionRetrospective studyTertiary care academic medical centerAggressive endoscopic approachStent placement strategyUnsuccessful endoscopic therapyDonor liver transplantationOptimal endoscopic treatmentAcademic medical centerDuct anastomosisInitial therapyBile leakageEndoscopic dilationBalloon dilationCommon complicationComplication rate
2011
Endoscopic Treatment of Anastomotic Biliary Strictures After Living Donor Liver Transplantation: Outcomes After Maximal Stent Therapy
Hsieh T, Harrison M, Crowell M, Mekeel K, Aqel B, Carey E, Byrne T, Vargas H, Douglas D, Rakela J, Reddy K, Moss A, Mulligan D. Endoscopic Treatment of Anastomotic Biliary Strictures After Living Donor Liver Transplantation: Outcomes After Maximal Stent Therapy. Clinical Gastroenterology And Hepatology 2011, 9: 184. DOI: 10.1016/j.cgh.2010.11.016.Peer-Reviewed Original Research
2010
What Hepatologists Should Know about Liver Transplant Surgery
Mekeel K, Mulligan D. What Hepatologists Should Know about Liver Transplant Surgery. 2010, 305-316. DOI: 10.1002/9781444325249.ch30.Peer-Reviewed Original ResearchLiver transplantationExcellent long-term patient outcomesLong-term patient outcomesDonor liver transplantationLiver transplant surgeryBiliary complicationsDonor allograftsMultidisciplinary careSurgical outcomesTransplant surgeryDonor poolPatient outcomesTransplant operationHepatic anatomyPhysiologic eventsHepatologistsComplicationsPatientsTransplantationOutcomesAllograftsSurgeryHepatectomyDiagnosisCare
2009
Living donor liver transplantation and donor graft size: How small can we go to reduce risk to the donor and what is the cost to the recipient?
Mulligan D. Living donor liver transplantation and donor graft size: How small can we go to reduce risk to the donor and what is the cost to the recipient? Liver Transplantation 2009, 15: 1392-1394. PMID: 19877257, DOI: 10.1002/lt.21922.Peer-Reviewed Original ResearchConceptsDonor liver transplantationDonor graft sizeLiver transplantationGraft sizeTransplantationRecipients
2008
HEPATIC ARTERY THROMBOSIS AFTER ADULT LIVING DONOR LIVER TRANSPLANTATION: RISK FACTORS AND MANAGEMENT FOR SUCCESSFUL OUTCOMES
Mulligan D, Moss A, Reddy S, Mekeel K, Byrne T, Carey E, Harrison M, Vargas H, Douglas D, Rakela J. HEPATIC ARTERY THROMBOSIS AFTER ADULT LIVING DONOR LIVER TRANSPLANTATION: RISK FACTORS AND MANAGEMENT FOR SUCCESSFUL OUTCOMES. Transplantation 2008, 86: 47. DOI: 10.1097/01.tp.0000332676.37855.56.Peer-Reviewed Original ResearchA CHANGE IN BILIARY ANASTOMOTIC TECHNIQUE LEADS TO A SIGNIFICANT IMPACT ON COMPLICATIONS FOLLOWING ADULT LIVING DONOR LIVER TRANSPLANTATION (LDLT)
Moss A, Mekeel K, Reddy K, Harrison M, Douglas D, Vargas H, Carey E, Byrne T, Mulligan D. A CHANGE IN BILIARY ANASTOMOTIC TECHNIQUE LEADS TO A SIGNIFICANT IMPACT ON COMPLICATIONS FOLLOWING ADULT LIVING DONOR LIVER TRANSPLANTATION (LDLT). Transplantation 2008, 86: 442. DOI: 10.1097/01.tp.0000331447.70202.92.Peer-Reviewed Original ResearchLiving donor liver transplantation in polycystic liver disease
Mekeel KL, Moss AA, Reddy KS, Douglas DD, Vargas HE, Carey EJ, Byrne TJ, Harrison ME, Rakela J, Mulligan DC. Living donor liver transplantation in polycystic liver disease. Liver Transplantation 2008, 14: 680-683. PMID: 18433036, DOI: 10.1002/lt.21423.Peer-Reviewed Original ResearchConceptsPolycystic liver diseaseDonor liver transplantationLiver transplantationLiver diseaseLiver functionEnd-Stage Liver Disease (MELD) systemDeceased donor liver transplantDonor liver transplantLiver transplantCaval resectionPoor qualityMassive hepatomegalyPatient survivalLiving donationPatientsHepatomegalyTransplantationHepatectomyDiseaseIdeal optionLDLTResectionComplicationsTransplantGraft
2007
Endoscopic treatment of anastomotic biliary strictures after deceased donor liver transplantation: outcomes after maximal stent therapy
Pasha SF, Harrison ME, Das A, Nguyen CC, Vargas HE, Balan V, Byrne TJ, Douglas DD, Mulligan DC. Endoscopic treatment of anastomotic biliary strictures after deceased donor liver transplantation: outcomes after maximal stent therapy. Gastrointestinal Endoscopy 2007, 66: 44-51. PMID: 17591473, DOI: 10.1016/j.gie.2007.02.017.Peer-Reviewed Original ResearchConceptsDeceased donor liver transplantationAnastomotic biliary stricturesDonor liver transplantationLiver transplantationEndoscopic therapyStent placementBiliary stricturesEndoscopic treatmentBiliary dilationEndoscopic dilationSurgical interventionTertiary care academic medical centerAggressive endoscopic approachAggressive endoscopic therapyBile duct patencyResolution of stricturesMultiple stent placementOptimal endoscopic treatmentAcademic medical centerPersistent resolutionProlonged therapyMedian durationBalloon dilationMajor complicationsRecurrent strictureKluyvera co‐infection in two solid organ transplant recipients: an emerging pathogen or a colonizer bystander?
Cheruvattath R, Balan V, Stewart R, Heilman RL, Mulligan DC, Kusne S. Kluyvera co‐infection in two solid organ transplant recipients: an emerging pathogen or a colonizer bystander? Transplant Infectious Disease 2007, 9: 83-86. PMID: 17313481, DOI: 10.1111/j.1399-3062.2006.00198.x.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsOrgan transplant recipientsTransplant recipientsDeceased donor kidney transplantAlpha-1 antitrypsin deficiencyDonor liver transplantationDonor kidney transplantsFocal segmental glomerulosclerosisAntibiotic coverageLiver transplantationTransplant patientsKidney transplantRenal failureUrinary infectionUrine cultureImmunocompetent hostsPatient populationSerious infectionsSegmental glomerulosclerosisAntitrypsin deficiencyNegative bacilliKluyvera infectionsMixed organismsAbscess aspirateCommensal organisms
2006
CHANGES IN SF-36 QUALITY OF LIFE (QOL) SCALES AFTER RIGHT HEPATECTOMY FOR ADULT LIVING DONOR LIVER TRANSPLANTATION (ALDLT).
Cheruvattath R, Douglas D, Russell L, Byrne T, Balan V, Vargas H, Rakela J, Chopra K, Carey E, Harrison M, Reddy K, Moss A, Mulligan D. CHANGES IN SF-36 QUALITY OF LIFE (QOL) SCALES AFTER RIGHT HEPATECTOMY FOR ADULT LIVING DONOR LIVER TRANSPLANTATION (ALDLT). Transplantation 2006, 82: 466. DOI: 10.1097/00007890-200607152-01200.Peer-Reviewed Original ResearchReduced Priority MELD Score for Hepatocellular Carcinoma Does Not Adversely Impact Candidate Survival Awaiting Liver Transplantation
Sharma P, Harper AM, Hernandez JL, Heffron T, Mulligan DC, Wiesner RH, Balan V. Reduced Priority MELD Score for Hepatocellular Carcinoma Does Not Adversely Impact Candidate Survival Awaiting Liver Transplantation. American Journal Of Transplantation 2006, 6: 1957-1962. PMID: 16771808, DOI: 10.1111/j.1600-6143.2006.01411.x.Peer-Reviewed Original ResearchConceptsDeceased donor liver transplantationHepatocellular carcinomaHCC candidatesCandidate survivalLiver transplantationMELD scoreStage T1Waiting listEnd-stage liver diseaseDonor liver transplantationT2 hepatocellular carcinomaOrgan allocation policyUNOS databaseLiver transplantLiver diseasePatient survivalUnited NetworkHCC patientsIncidence rateOrgan SharingSurvivalTransplantationCarcinomaDropout rateTime periodLiver Transplantation in the MELD Era: A Single-Center Experience
Sachdev M, Hernandez JL, Sharma P, Douglas DD, Byrne T, Harrison ME, Mulligan D, Moss A, Reddy K, Vargas HE, Rakela J, Balan V. Liver Transplantation in the MELD Era: A Single-Center Experience. Digestive Diseases And Sciences 2006, 51: 1070-1078. PMID: 16865573, DOI: 10.1007/s10620-006-8011-1.Peer-Reviewed Original ResearchMeSH KeywordsArizonaCarcinoma, HepatocellularFemaleHepatitis CHumansLiver DiseasesLiver NeoplasmsLiver TransplantationMaleMedical RecordsMiddle AgedOutcome Assessment, Health CareResource AllocationRetrospective StudiesRisk AssessmentSeverity of Illness IndexSurvival AnalysisTissue and Organ ProcurementWaiting ListsConceptsDeceased donor liver transplantationLiver transplantationTransplantation ratesEndstage Liver Disease (MELD) scoreImpact of MELDDonor liver transplantationLiver Disease scoreUnderlying liver diseaseSingle-center experienceHepatocellular carcinoma patientsHepatitis C virusNew allocation policyHCC candidatesMELD implementationNew MELDTimely transplantClinical deteriorationMELD eraCarcinoma patientsLiver diseaseHepatitis C virus groupC virusHCC patientsMayo ClinicDropout rateLiving donor liver transplantation for hepatitis C‐related cirrhosis: No difference in histological recurrence when compared to deceased donor liver transplantation recipients
Guo L, Orrego M, Rodriguez‐Luna H, Balan V, Byrne T, Chopra K, Douglas DD, Harrison E, Moss A, Reddy KS, Williams JW, Rakela J, Mulligan D, Vargas HE. Living donor liver transplantation for hepatitis C‐related cirrhosis: No difference in histological recurrence when compared to deceased donor liver transplantation recipients. Liver Transplantation 2006, 12: 560-565. PMID: 16555313, DOI: 10.1002/lt.20660.Peer-Reviewed Original ResearchConceptsDeceased donor liver transplantationDonor liver transplantationLiver transplantationHistological recurrenceHepatitis CDeceased-donor liver transplantation (DDLT) recipientsEnd-stage liver disease (MELD) scoreDonor liver transplantation recipientsHepatitis C virus infectionKaplan-Meier survival analysisDetectable HCV RNAHistological recurrence rateC virus infectionGraft survival ratesLiver Disease scoreActivity of inflammationLiver transplantation recipientsStatistical differenceChild-TurcotteDDLT groupLDLT patientsPugh scoreRecurrent HCVLiver transplantYears posttransplantation
2004
Hepatopulmonary syndrome after living donor liver transplantation and deceased donor liver transplantation: A single‐center experience
Carey EJ, Douglas DD, Balan V, Vargas HE, Byrne TJ, Moss AA, Mulligan DC. Hepatopulmonary syndrome after living donor liver transplantation and deceased donor liver transplantation: A single‐center experience. Liver Transplantation 2004, 10: 529-533. PMID: 15048796, DOI: 10.1002/lt.20127.Peer-Reviewed Original ResearchConceptsDeceased donor liver transplantationDonor liver transplantationHepatopulmonary syndromeLiver transplantationShunt fractionEnd-stage liver diseaseLiver transplant recipientsSingle-center experienceNormal pulmonary functionMean shunt fractionTransplant recipientsMean PaO2Pulmonary functionLiver diseaseSingle centerSupplemental oxygenNatural courseTransplantationHepatic regenerationSmall seriesPatientsLDLTPaO2SyndromeComplicationsLiver transplantation for hepatocellular carcinoma: The MELD impact
Sharma P, Balan V, Hernandez JL, Harper AM, Edwards EB, Rodriguez‐Luna H, Byrne T, Vargas HE, Mulligan D, Rakela J, Wiesner RH. Liver transplantation for hepatocellular carcinoma: The MELD impact. Liver Transplantation 2004, 10: 36-41. PMID: 14755775, DOI: 10.1002/lt.20012.Peer-Reviewed Original ResearchConceptsDeceased donor liver transplantationNew allocation policyHCC candidatesPerson yearsIncidence rateHepatocellular carcinomaLiver transplantationUNOS databaseEnd-stage liver diseaseT2 hepatocellular carcinomaDonor liver transplantationDropout rateDate of implementationHepatic decompensationNew MELDClinical deteriorationMELD scoreLiver diseaseStage T1United NetworkOrgan SharingWaiting listSurvivalTransplantationCarcinoma
2003
Recent Advances in Liver Transplantation
Wiesner RH, Rakela J, Ishitani MB, Mulligan DC, Spivey JR, Steers JL, Krom RA. Recent Advances in Liver Transplantation. Mayo Clinic Proceedings 2003, 78: 197-210. PMID: 12583530, DOI: 10.4065/78.2.197.Peer-Reviewed Original ResearchConceptsLiver transplantationHepatitis CEnd-stage liver disease (MELD) allocation systemRecurrent hepatitis C.Acute cellular rejectionDonor liver transplantationRecurrent hepatitis CDeath of patientsLong-term survivalLiver allocation policyQuality of lifeCellular rejectionChronic rejectionDomino transplantationImmunosuppressive regimensMetabolic complicationsRecurrent diseaseHepatitis C.Marginal donorsProlong survivalUnited NetworkHepatic support systemDonor poolEffective therapyDonor organs