2003
Tacrolimus as a liver flush solution to ameliorate the effects of ischemia/reperfusion injury following liver transplantation
St. Peter SD, Post DJ, Rodriguez‐Davalos M, Douglas DD, Moss AA, Mulligan DC. Tacrolimus as a liver flush solution to ameliorate the effects of ischemia/reperfusion injury following liver transplantation. Liver Transplantation 2003, 9: 144-149. PMID: 12548508, DOI: 10.1053/jlts.2003.50018.Peer-Reviewed Original ResearchConceptsIschemia/reperfusion injuryTacrolimus treatmentReperfusion injuryFlush solutionGroup 2Group 1Partial thromboplastin time valuesBaseline aspartate aminotransferaseEarly graft functionOrthotopic liver transplantProspective randomized fashionTotal ischemia timeSerum laboratory valuesSuperior early graft functionGraft functionLiver transplantLiver transplantationHepatic allograftsHepatocellular injuryLiver injuryPlacebo treatmentLiver diseasePlasma-Lyte AHepatocellular damageIschemia time
2001
Inhibition of the initial wave of NF‐κB activity in rat muscle reduces ischemia/reperfusion injury
Lille S, Lefler S, Mowlavi A, Suchy H, Boyle E, Farr A, Su C, Frank N, Mulligan D. Inhibition of the initial wave of NF‐κB activity in rat muscle reduces ischemia/reperfusion injury. Muscle & Nerve 2001, 24: 534-541. PMID: 11268026, DOI: 10.1002/mus.1037.Peer-Reviewed Original ResearchConceptsIschemia/reperfusion injuryNF-kappaB activationNF-kappaBReperfusion injurySevere ischemic stressNF-κB activityNuclear factor-kappaBRat skeletal muscleR injuryEarly reperfusionIschemic periodNeutrophil activityMuscle edemaIntravenous administrationIschemic stressReperfusionTherapeutic interventionsFactor-kappaBMuscle survivalIncreased percentageBiphasic patternInjurySkeletal muscleRat muscleActivity levels