2018
Prevention of Ischemic Injury in Colon and Small Intestine in an Ex Vivo Perfusion Animal Model
Finotti M, Lysyy T, Barahona M, Maina R, Caturegli G, D'Amico F, Mulligan D, Geibel J. Prevention of Ischemic Injury in Colon and Small Intestine in an Ex Vivo Perfusion Animal Model. Transplantation 2018, 102: s709. DOI: 10.1097/01.tp.0000543675.85457.d2.Peer-Reviewed Original ResearchIschemia-reperfusion injuryIschemic injuryIschemic damageL-arginineSmall intestineL-NAMEDistal colonPerfusion machineMale Sprague-Dawley ratsIntestinal ischemic damageIntestinal ischemic injuryAnti-ischemic effectsSprague-Dawley ratsIntestinal graftInflammatory injuryInflammatory pathwaysIntestinal viabilityProtective effectAbdominal cavityColon segmentsIschemic conditionsIntestinal wallIntraluminal secretionsAnimal modelsIntestine segments
2003
Effects of tacrolimus on ischemia‐reperfusion injury
St. Peter SD, Moss AA, Mulligan DC. Effects of tacrolimus on ischemia‐reperfusion injury. Liver Transplantation 2003, 9: 105-116. PMID: 12548502, DOI: 10.1053/jlts.2003.50020.Peer-Reviewed Original ResearchConceptsEffects of tacrolimusIschemia-reperfusion injuryCellular mechanismsCalcium-activated pathwaysInteractions of tacrolimusFree radical metabolismCornerstone agentEfficacious immunosuppressionInflammatory cascadeOrgan transplantationTacrolimusCytoprotective effectsTissue recoveryClinical literatureDiverse actionsRadical metabolismImmunosuppressionInjuryMitochondrial stabilityStress response proteinsReperfusionIschemiaTransplantationTranscription factorsMicrocirculation
2002
Activation Time Course of Activator Protein-1 and Effect of Proline Dithiocarbamate During Ischemia-Reperfusion in Rat Skeletal Muscle
Lefler SR, Lille ST, Huemer G, Tucker R, Murray T, Schoeller T, Mulligan DC. Activation Time Course of Activator Protein-1 and Effect of Proline Dithiocarbamate During Ischemia-Reperfusion in Rat Skeletal Muscle. Annals Of Plastic Surgery 2002, 49: 654-659. PMID: 12461450, DOI: 10.1097/00000637-200212000-00016.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryAP-1 activationRat skeletal muscleActivator protein-1Nuclear factor-kappa B (NF-κB) inhibitorSkeletal muscleAP-1Hours of reperfusionProtein 1Proline dithiocarbamateIschemia reperfusionIschemic periodIntravenous administrationBiphasic patternB inhibitorReperfusionActivation time courseFurther elucidationTime courseInjuryExpression of genesPerfusionDeleterious effectsMuscleHours