2021
Developing simultaneous liver‐kidney transplant medical eligibility criteria while providing a safety net: A 2‐year review of the OPTN's allocation policy
Wilk AR, Booker SE, Stewart DE, Wiseman A, Gauntt K, Mulligan D, Formica RN. Developing simultaneous liver‐kidney transplant medical eligibility criteria while providing a safety net: A 2‐year review of the OPTN's allocation policy. American Journal Of Transplantation 2021, 21: 3593-3607. PMID: 34254434, DOI: 10.1111/ajt.16761.Peer-Reviewed Original ResearchConceptsMedical Eligibility CriteriaEligibility criteriaLiver transplantPatient/graft survivalWaitlist mortality rateDeceased donor kidneysLiver recipientsSLK candidatesSLK transplantsGraft survivalRenal impairmentPosttransplant outcomesDonor kidneysTransplant ratesTransplant volumeMortality rateTransplantKidneySignificant differencesRecipientsSubsequent increaseLiver dataCriteriaImpairmentSLK
2020
Lysis of cold‐storage‐induced microvascular obstructions for ex vivo revitalization of marginal human kidneys
DiRito JR, Hosgood SA, Reschke M, Albert C, Bracaglia LG, Ferdinand JR, Stewart BJ, Edwards CM, Vaish AG, Thiru S, Mulligan DC, Haakinson DJ, Clatworthy MR, Saltzman WM, Pober JS, Nicholson ML, Tietjen GT. Lysis of cold‐storage‐induced microvascular obstructions for ex vivo revitalization of marginal human kidneys. American Journal Of Transplantation 2020, 21: 161-173. PMID: 32627324, PMCID: PMC7775334, DOI: 10.1111/ajt.16148.Peer-Reviewed Original ResearchConceptsNormothermic machine perfusionHuman kidneyMicrovascular obstructionMarginal organsHigh-risk donorsSevere organ shortageLikelihood of complicationsMicrovascular blood flowAccumulation of fibrinogenCold storage injuryTissue plasminogen activatorImmediate translational potentialMicrovascular pluggingRenal functionRenal injuryMachine perfusionTubular epitheliumBlood flowIntravascular releaseOrgan shortagePhysiologic impactKidneyTranslational potentialPlasminogen activatorVivo assessment
2012
Impact of Using Deceased Donor Kidneys with Acute Kidney Injury (AKI) on 1-Year Protocol Biopsy Findings
Heilman R, Smith M, Chakkera H, Khamash H, Hamawi K, Moss A, Katariya N, Mulligan D, Reddy K. Impact of Using Deceased Donor Kidneys with Acute Kidney Injury (AKI) on 1-Year Protocol Biopsy Findings. Transplantation 2012, 94: 243. DOI: 10.1097/00007890-201211271-00453.Peer-Reviewed Original ResearchBaseline Biopsy Findings and Clinical Outcomes in Recipients of Kidneys from Standard Criteria Donors (SCD) with Acute Kidney Injury (AKI)
Reddy K, Smith M, Chakkera H, Moss A, Mulligan D, Khamash H, Hewitt W, Katariya N, Heilman R. Baseline Biopsy Findings and Clinical Outcomes in Recipients of Kidneys from Standard Criteria Donors (SCD) with Acute Kidney Injury (AKI). Transplantation 2012, 94: 341. DOI: 10.1097/00007890-201211271-00631.Peer-Reviewed Original ResearchImpact of Using Deceased Donor Kidneys with Acute Kidney Injury (AKI) on 1-Year Protocol Biopsy Findings
Heilman R, Smith M, Chakkera H, Khamash H, Hamawi K, Moss A, Katariya N, Mulligan D, Reddy K. Impact of Using Deceased Donor Kidneys with Acute Kidney Injury (AKI) on 1-Year Protocol Biopsy Findings. Transplantation 2012, 94: 1021. DOI: 10.1097/00007890-201211271-02021.Peer-Reviewed Original ResearchPolyomavirus JC Urinary Shedding in Kidney and Liver Transplant Recipients Associated With Reduced Creatinine Clearance
Kusne S, Vilchez RA, Zanwar P, Quiroz J, Mazur MJ, Heilman RL, Mulligan D, Butel JS. Polyomavirus JC Urinary Shedding in Kidney and Liver Transplant Recipients Associated With Reduced Creatinine Clearance. The Journal Of Infectious Diseases 2012, 206: 875-880. PMID: 22802433, PMCID: PMC3501156, DOI: 10.1093/infdis/jis469.Peer-Reviewed Original ResearchConceptsJohn Cunningham virusSolid organ transplant recipientsLiver transplant recipientsOrgan transplant recipientsTransplant recipientsBK virusTransplant patientsUrinary sheddingKidney recipientsCreatinine clearanceReduced creatinine clearanceKidney transplant patientsLiver transplant patientsOrgan transplant patientsPolyomavirus BK virusJCV loadLiver recipientsPolyomavirus reactivationRenal dysfunctionSignificant morbidityPatient groupCrCl valuesLiver patientsPatientsKidney
2010
ASSOCIATION OF A COMPOSITE SET OF PREDICTORS PRE TRANSPLANTATION AND NEW ONSET DIABETES MELLITUS AFTER KIDNEY TRANSPLANTATION
Chakkera H, Devarapalli Y, Reddy K, Mulligan D, Mazur M, Hamawi K, Moss A, Mekeel K, Swanson C, Heilman R. ASSOCIATION OF A COMPOSITE SET OF PREDICTORS PRE TRANSPLANTATION AND NEW ONSET DIABETES MELLITUS AFTER KIDNEY TRANSPLANTATION. Transplantation 2010, 90: 928. DOI: 10.1097/00007890-201007272-01820.Peer-Reviewed Original ResearchSuccessful Transplantation of a Split Crossed Fused Ectopic Kidney into a Patient with End‐Stage Renal Disease
Mekeel KL, Daley SM, Andrews PE, Moss AA, Heilman RL, Mazur MJ, Chakkera HA, Hamawi K, Mulligan DC, Reddy K. Successful Transplantation of a Split Crossed Fused Ectopic Kidney into a Patient with End‐Stage Renal Disease. Journal Of Transplantation 2010, 2010: 383972. PMID: 20368777, PMCID: PMC2846343, DOI: 10.1155/2010/383972.Peer-Reviewed Original ResearchFused ectopic kidneyEctopic kidneySimultaneous kidney-pancreas transplantDeceased donor kidney transplantEnd-stage renal diseaseCongenital renal anomaliesKidney-pancreas transplantNormal renal functionDonor kidney transplantsPancreas transplantsKidney transplantRenal functionRenal diseaseParenchymal transectionRenal anomaliesSuccessful transplantationImmediate functionWaiting listTransplantPotential transplantsExcellent functionKidneyPotential donorsPatientsTransplantation
2009
Simultaneous Heart and Kidney Transplantation After Bridging With The CardioWest Total Artificial Heart
Jaroszewski DE, Pierce CC, Staley LL, Wong R, Scott RR, Steidley EE, Gopalan RS, DeValeria P, Lanza L, Mulligan D, Arabia FA. Simultaneous Heart and Kidney Transplantation After Bridging With The CardioWest Total Artificial Heart. The Annals Of Thoracic Surgery 2009, 88: 1324-1326. PMID: 19766830, DOI: 10.1016/j.athoracsur.2009.02.056.Peer-Reviewed Original ResearchConceptsCardioWest total artificial heartTotal artificial heartRenal failureEnd-stage renal failureTotal artificial heart implantationRisk of mortalityArtificial heart implantationArtificial heartSimultaneous heartCardiac transplantationKidney transplantationRelative contraindicationHeart implantationSuccessful treatmentTransplantationHeartContraindicationsPatientsFailureKidneyMortality
2007
Diffuse Parenchymal Urine Leak After Kidney Transplantation Following Degloving Injury During Donor Nephrectomy
Mekeel KL, Mazur MJ, Reddy KS, Mulligan DC, Heilman RL, Chakkera HA, Andrews PE, Moss AA. Diffuse Parenchymal Urine Leak After Kidney Transplantation Following Degloving Injury During Donor Nephrectomy. American Journal Of Transplantation 2007, 7: 2039-2041. PMID: 17578504, DOI: 10.1111/j.1600-6143.2007.01870.x.Peer-Reviewed Original ResearchConceptsDonor nephrectomyUrine leakRecipient graft functionGood renal functionLaparoscopic donor nephrectomyComplete deglovingGraft functionKidney transplantationPostoperative courseRenal functionPeritoneal windowLarge urinomaGlue treatmentKidneyUnconcentrated urineKidney surfaceNephrectomyLeakUrinomaPatientsTransplantationDeglovingInjuryTraumaUrine