2023
Living Donor Liver Transplantation for Hepatocellular Carcinoma Within and Outside Traditional Selection Criteria
Ivanics T, Claasen M, Samstein B, Emond J, Fox A, Pomfret E, Pomposelli J, Tabrizian P, Florman S, Mehta N, Roberts J, Emamaullee J, Genyk Y, Hernandez-Alejandro R, Tomiyama K, Sasaki K, Hashimoto K, Nagai S, Abouljoud M, Olthoff K, Hoteit M, Heimbach J, Taner T, Liapakis A, Mulligan D, Sapisochin G, Halazun K, Group O. Living Donor Liver Transplantation for Hepatocellular Carcinoma Within and Outside Traditional Selection Criteria. Annals Of Surgery 2023, 279: 104-111. PMID: 37522174, DOI: 10.1097/sla.0000000000006049.Peer-Reviewed Original ResearchConceptsUniversity of California San FranciscoMilan criteriaDonor liver transplantationHepatocellular carcinomaOverall survivalLiver transplantationPosttransplantation survivalEvaluate long-term oncologic outcomesUniversity of California San Francisco criteriaLiving donor liver transplantationRecurrence-free survivalKaplan-Meier methodTransplant selection criteriaProportion of patientsAdult LDLT recipientsNorth American centersLong-term survivalLiver transplant waitlistCalifornia San FranciscoLDLT recipientsMulticenter cohortConsensus guidelinesTransplantationPatientsPosttransplantationLiving donor liver transplant candidate and donor selection and engagement: Meeting report from the living donor liver transplant consensus conference
Jesse M, Jackson W, Liapakis A, Ganesh S, Humar A, Goldaracena N, Levitsky J, Mulligan D, Pomfret E, Ladner D, Roberts J, Mavis A, Thiessen C, Trotter J, Winder G, Griesemer A, Pillai A, Kumar V, Verna E, Rudow D, Han H, Group T. Living donor liver transplant candidate and donor selection and engagement: Meeting report from the living donor liver transplant consensus conference. Clinical Transplantation 2023, 37: e14954. PMID: 36892182, DOI: 10.1111/ctr.14954.Peer-Reviewed Original ResearchConceptsDonor selectionConsensus conferenceDeceased donor organ shortageDonor liver transplantationLiver transplant candidatesDonor organ shortageLiver transplantationTransplant candidatesWaitlist mortalityExcellent outcomesLDLT candidatesOrgan shortageDonation outcomesLack of standardizationAmerican SocietyTransplantationDelphi approachBroad implementationMeeting reportOutcomesCandidate indicationsReportLDLTPatientsBroad uptakeA review of the current and future role of robotic surgery in liver surgery and transplantation
Finotti M, D’Amico F, Mulligan D, Testa G. A review of the current and future role of robotic surgery in liver surgery and transplantation. HepatoBiliary Surgery And Nutrition 2023, 0: 0-0. PMID: 36860258, PMCID: PMC9944521, DOI: 10.21037/hbsn-21-115.Peer-Reviewed Original ResearchDonor hepatectomyLiver surgeryLiver transplantationRobotic approachLiving donationRobotic surgeryGood bleeding controlLaparoscopic donor hepatectomyRobotic liver surgeryInvasive liver surgeryLaparoscopic liver surgeryLonger operation timePostoperative painOpen surgeryRapid learning curveVascular injuryBiliary anatomyTransplant fieldBleeding controlLiver tumorsSurgeryFollowing keywordsHepatectomyNarrative reviewTechnique of choicePerceptions and Early Outcomes of the Acuity Circles Allocation Policy Among Liver Transplant Centers in the United States
Pawlak N, Song C, Alvi S, Schuster K, Segalini N, Kwon Y, Akoad M, Rauf M, Mulligan D, Aziz H. Perceptions and Early Outcomes of the Acuity Circles Allocation Policy Among Liver Transplant Centers in the United States. Transplantation Direct 2023, 9: e1427. PMID: 36582673, PMCID: PMC9750633, DOI: 10.1097/txd.0000000000001427.Peer-Reviewed Original Research
2022
Epidemiology and outcomes of surgical site infections among pediatric liver transplant recipients
Banach DB, Lopez‐Verdugo F, Sanchez‐Garcia J, Tran A, Gomez‐Llerena A, Munoz‐Abraham A, Bertacco A, Valentino PL, Yoo P, Dembry L, Mulligan DC, Ekong UD, Emre SH, Rodriguez‐Davalos M. Epidemiology and outcomes of surgical site infections among pediatric liver transplant recipients. Transplant Infectious Disease 2022, 24: e13941. PMID: 35989545, DOI: 10.1111/tid.13941.Peer-Reviewed Original ResearchConceptsSurgical site infectionLiver transplant recipientsLiver transplantationBiliary complicationsGraft recipientsTransplant recipientsSite infectionRisk factorsOutcomes of SSIPediatric liver transplant recipientsLong-term graftPediatric liver transplantationRetrospective descriptive analysisPrimary endpointHospital daysPatient agePediatric populationPatient survivalSignificant causeComplicationsPatientsRecipientsOutcomesInfectionIncidence
2021
Bile Microbiota in Liver Transplantation: Proof of Concept Using Gene Amplification in a Heterogeneous Clinical Scenario
D'Amico F, Bertacco A, Finotti M, Di Renzo C, Rodriguez-Davalos MI, Gondolesi GE, Cillo U, Mulligan D, Geibel J. Bile Microbiota in Liver Transplantation: Proof of Concept Using Gene Amplification in a Heterogeneous Clinical Scenario. Frontiers In Surgery 2021, 8: 621525. PMID: 33796547, PMCID: PMC8009296, DOI: 10.3389/fsurg.2021.621525.Peer-Reviewed Original ResearchBile microbiotaLiver donorsBiliary tract diseaseCommon bile ductGene amplificationRibosomal RNA gene amplificationLiver recipientsLiver transplantationPediatric recipientsLiver proceduresBiliary tractBile ductRecipient patientsTract diseaseBile samplesHeterogeneous cohortClinical scenariosBileSterile wayPCR sequencingPatientsRecipientsMicrobiotaTransplantationGallbladder
2020
The Impact of COVID‐19 on Organ Donation, Procurement, and Liver Transplantation in the United States
Merola J, Schilsky ML, Mulligan DC. The Impact of COVID‐19 on Organ Donation, Procurement, and Liver Transplantation in the United States. Hepatology Communications 2020, 5: 5-11. PMID: 33043228, PMCID: PMC7537114, DOI: 10.1002/hep4.1620.Peer-Reviewed Original ResearchLiver transplantationOrgan recoveryOrgan transplantationSevere acute respiratory syndrome coronavirus type 2End-stage liver diseaseOrgan donationExpected excellent outcomesLiver transplant recipientsCoronavirus disease 2019 (COVID-19) pandemicCoronavirus type 2Life-saving procedureCoronavirus disease 2019Disease 2019 pandemicOrgan procurement organizationsHealth care systemTransplant recipientsOrgan failureLiver diseaseDonor evaluationExcellent outcomesDisease 2019New practice paradigmHospital resourcesType 2Particular patient
2019
Portopulmonary Hypertension: A Survey of Practice Patterns and Provider Attitudes
DuBrock HM, Salgia RJ, Sussman NL, Bartolome SD, Kadry Z, Mulligan DC, Jenkins S, Lackore K, Channick RN, Kawut SM, Krowka MJ. Portopulmonary Hypertension: A Survey of Practice Patterns and Provider Attitudes. Transplantation Direct 2019, 5: e456. PMID: 31321292, PMCID: PMC6553621, DOI: 10.1097/txd.0000000000000900.Peer-Reviewed Original ResearchPortopulmonary hypertensionLiver transplantationManagement of patientsPractice patternsProvider attitudesCurrent guidelinesElevated mean pulmonary arterial pressureMean pulmonary arterial pressureNormal pulmonary vascular resistanceMulticenter survey studyPulmonary vascular resistancePulmonary arterial pressureFisher's exact testWilcoxon rank sumPercent of respondentsVascular resistanceArterial pressureLT centersProspective studyPractice guidelinesClinical practiceExact testPatientsChi-squareHepatologists
2017
Inequity in organ allocation for patients awaiting liver transplantation: Rationale for uncapping the model for end-stage liver disease
Nadim MK, DiNorcia J, Ji L, Groshen S, Levitsky J, Sung RS, Kim WR, Andreoni K, Mulligan D, Genyk YS. Inequity in organ allocation for patients awaiting liver transplantation: Rationale for uncapping the model for end-stage liver disease. Journal Of Hepatology 2017, 67: 517-525. PMID: 28483678, PMCID: PMC7735955, DOI: 10.1016/j.jhep.2017.04.022.Peer-Reviewed Original ResearchConceptsEnd-stage liver diseaseLiver transplantMELD scoreLiver diseaseSick patientsLiver transplantationOrgan allocationEquitable organ distributionGreater MELD scoresPost-transplant outcomesOrgan Sharing dataPost-transplant survivalUnderwent liver transplantObjective scoring systemWaitlist registrationWaitlist mortalityHazard ratioSurvival benefitWaitlist candidatesUnited NetworkPatientsTransplantScoring systemMELDOrgan distributionLiver allocation and distribution
Deshpande R, Hirose R, Mulligan D. Liver allocation and distribution. Current Opinion In Organ Transplantation 2017, 22: 162-168. PMID: 28212159, DOI: 10.1097/mot.0000000000000397.Peer-Reviewed Original ResearchConceptsTransplant CommitteeTransplant centersEnd-Stage Liver Disease (MELD) pointsLiver allograft allocationDeceased donor liversLife-saving organsLiver allocation policyAllograft allocationLiver transplantLiver transplantationLiver diseaseDonor liversUnited NetworkDonor organsLiver distributionAdvanced stageLiver allocationOrgan distributionPatient accessTransplantationGeographic disparitiesLiverDisease pointHealthcare systemPatients
2016
Risks and Epidemiology of Infections After Liver Transplantation
Patron R, Kusne S, Mulligan D. Risks and Epidemiology of Infections After Liver Transplantation. 2016, 215-233. DOI: 10.1007/978-3-319-28797-3_14.Peer-Reviewed Original ResearchInfectious complicationsAppropriate antimicrobial prophylaxisDonor-transmitted infectionLiver transplant recipientsSerious infectious complicationsPrevention of recurrenceEpidemiology of infectionGraft lossHIV coinfectionAntimicrobial prophylaxisLiver transplantLiver transplantationTransplant recipientsOperative timeViral hepatitidesImmune competencePrompt interventionRisk factorsDiligent surveillanceSurgical techniqueSolid organsHigh riskTherapeutic strategiesAnti-infective agentsEarly signsPostoperative delirium is associated with increased intensive care unit and hospital length of stays after liver transplantation
Bhattacharya B, Maung A, Barre K, Maerz L, Rodriguez-Davalos MI, Schilsky M, Mulligan DC, Davis KA. Postoperative delirium is associated with increased intensive care unit and hospital length of stays after liver transplantation. Journal Of Surgical Research 2016, 207: 223-228. PMID: 27979481, DOI: 10.1016/j.jss.2016.08.084.Peer-Reviewed Original ResearchConceptsLiver transplantationHospital lengthEnd-stage liver disease (MELD) scoreIntensive care unit LOSHigher preoperative modelImportant postoperative complicationLiver Disease scoreLiver transplant patientsImpact of deliriumTertiary care centerRetrospective case seriesUrinary tract infectionFurther prospective studiesIntensive care unitLong-term outcomesSpecific risk factorsFrequency of hospitalPaucity of dataPostoperative deliriumPostoperative hospitalPostoperative complicationsTransplant patientsVentilator daysAdult patientsDelirious patientsWhat Every Hepatologist Should Know about Liver Transplantation
Yoo P, Mulligan D. What Every Hepatologist Should Know about Liver Transplantation. 2016, 608-616. DOI: 10.1002/9781119127437.ch93.Peer-Reviewed Original ResearchLiver transplantationPiggyback techniqueExcellent long-term patient outcomesLong-term patient outcomesHepatic venous complicationsRetrohepatic vena cavaDonor liver transplantationLiver transplant patientsRisk of complicationsBiliary complicationsSplit liverTransplant patientsTransplant recipientsVenous complicationsDonor transplantsMultidisciplinary careVena cavaDonor poolPatient outcomesTransplant operationSurgical techniqueOrgan allocationPhysiologic circumstancesComplicationsSuccessful outcome
2015
Non‐alcoholic fatty liver disease following liver transplantation: a clinical review
Merola J, Liapakis A, Mulligan DC, Yoo PS. Non‐alcoholic fatty liver disease following liver transplantation: a clinical review. Clinical Transplantation 2015, 29: 728-737. PMID: 26147308, DOI: 10.1111/ctr.12585.Peer-Reviewed Original ResearchConceptsNon-alcoholic steatohepatitisLiver transplantationRisk factorsNon-alcoholic fatty liver diseasePost-transplant metabolic syndromePost-transplant settingCardiovascular risk factorsPost-transplantation outcomesSignificant survival benefitFatty liver diseaseCause of deathCardiovascular mortalitySurvival benefitMetabolic syndromeLiver diseaseClinical reviewPatient populationSurgical approachTreatment approachesTransplantationRecent evidenceIndicationsSteatohepatitisTransplantSyndromeDisparity, Liver Demand, and Access to Transplants
Mulligan D. Disparity, Liver Demand, and Access to Transplants. American Journal Of Transplantation 2015, 15: 1746-1747. PMID: 25929170, DOI: 10.1111/ajt.13302.Peer-Reviewed Original Research
2013
New Onset Diabetes Mellitus in Living Donor versus Deceased Donor Liver Transplant Recipients: Analysis of the UNOS/OPTN Database
Yadav AD, Chang YH, Aqel BA, Byrne TJ, Chakkera HA, Douglas DD, Mulligan DC, Rakela J, Vargas HE, Carey EJ. New Onset Diabetes Mellitus in Living Donor versus Deceased Donor Liver Transplant Recipients: Analysis of the UNOS/OPTN Database. Journal Of Transplantation 2013, 2013: 269096. PMID: 24205434, PMCID: PMC3800575, DOI: 10.1155/2013/269096.Peer-Reviewed Original ResearchDonor liver transplant recipientsAcute cellular rejectionLiver transplant recipientsDeceased donor liver transplant recipientsDDLT recipientsLDLT recipientsTransplant recipientsRisk factorsNew onsetTransplant Network/United NetworkUNOS/OPTN databaseOrgan Sharing databaseIncidence of NODATBody mass indexTimely clinical interventionCellular rejectionDonor diabetesNondiabetic recipientsHepatitis CLiver transplantationRecipient ageSharing databaseMass indexOverall incidencePredictive factors
2012
Endoscopic treatment of anastomotic biliary strictures after living donor liver transplantation: outcomes after maximal stent therapy
Hsieh TH, Mekeel KL, Crowell MD, Nguyen CC, Das A, Aqel BA, Carey EJ, Byrne TJ, Vargas HE, Douglas DD, Mulligan DC, Harrison ME. Endoscopic treatment of anastomotic biliary strictures after living donor liver transplantation: outcomes after maximal stent therapy. Gastrointestinal Endoscopy 2012, 77: 47-54. PMID: 23062758, DOI: 10.1016/j.gie.2012.08.034.Peer-Reviewed Original ResearchMeSH KeywordsAlanine TransaminaseAlkaline PhosphataseAspartate AminotransferasesBiliary Tract DiseasesBilirubinCholangiopancreatography, Endoscopic RetrogradeCholestasisEndoscopy, Digestive SystemFemaleFollow-Up StudiesHumansLiver TransplantationLiving DonorsMalePostoperative ComplicationsRecurrenceRetrospective StudiesStentsTreatment OutcomeConceptsLiving-donor liver transplantationAnastomotic biliary stricturesEndoscopic retrograde cholangiographyPercutaneous transhepatic cholangiographyBiliary stricturesEndoscopic therapyLiver transplantationEndoscopic treatmentRetrograde cholangiographySurgical revisionRetrospective studyTertiary care academic medical centerAggressive endoscopic approachStent placement strategyUnsuccessful endoscopic therapyDonor liver transplantationOptimal endoscopic treatmentAcademic medical centerDuct anastomosisInitial therapyBile leakageEndoscopic dilationBalloon dilationCommon complicationComplication ratePretransplant Fasting Glucose Predicts New‐Onset Diabetes after Liver Transplantation
Carey EJ, Aqel BA, Byrne TJ, Douglas DD, Rakela J, Vargas HE, Moss AA, Mulligan DC, Reddy KS, Chakkera HA. Pretransplant Fasting Glucose Predicts New‐Onset Diabetes after Liver Transplantation. Journal Of Transplantation 2012, 2012: 614781. PMID: 22461975, PMCID: PMC3306927, DOI: 10.1155/2012/614781.Peer-Reviewed Original ResearchLiving-donor transplantsLiver transplant recipientsIncidence of NODATLiver transplantTransplant recipientsRisk factorsNew-onset diabetesLiver transplantationMELD scoreFasting GlucoseDL increasePoor outcomeMean ageNODATOnset diabetesHCVMultivariate analysisTransplantationTransplantFPGCorticosteroidsDiabetesPatientsIncidenceTwofold increase
2011
Endoscopic Treatment of Anastomotic Biliary Strictures After Living Donor Liver Transplantation: Outcomes After Maximal Stent Therapy
Hsieh T, Harrison M, Crowell M, Mekeel K, Aqel B, Carey E, Byrne T, Vargas H, Douglas D, Rakela J, Reddy K, Moss A, Mulligan D. Endoscopic Treatment of Anastomotic Biliary Strictures After Living Donor Liver Transplantation: Outcomes After Maximal Stent Therapy. Clinical Gastroenterology And Hepatology 2011, 9: 184. DOI: 10.1016/j.cgh.2010.11.016.Peer-Reviewed Original Research
2010
Hepatic epithelioid haemangioendothelioma: is transplantation the only treatment option?
Grotz TE, Nagorney D, Donohue J, Que F, Kendrick M, Farnell M, Harmsen S, Mulligan D, Nguyen J, Rosen C, Reid-Lombardo K. Hepatic epithelioid haemangioendothelioma: is transplantation the only treatment option? Hepato Pancreato Biliary 2010, 12: 546-553. PMID: 20887322, PMCID: PMC2997660, DOI: 10.1111/j.1477-2574.2010.00213.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntineoplastic AgentsChi-Square DistributionDisease-Free SurvivalFemaleHemangioendothelioma, EpithelioidHepatectomyHumansKaplan-Meier EstimateLiver NeoplasmsLiver TransplantationMaleMiddle AgedPalliative CareProportional Hazards ModelsRetrospective StudiesRisk AssessmentRisk FactorsSurvival RateTime FactorsTreatment OutcomeUnited StatesYoung AdultConceptsHepatic epithelioid haemangioendotheliomaOrthotopic liver transplantationDisease-free survivalLiver resectionOverall survivalPrognostic factorsFavorable prognostic factorUnfavourable prognostic factorOnly treatment optionUnpredictable clinical behaviorRare vascular neoplasmResectable diseaseUnresectable diseaseEpithelioid haemangioendotheliomaLiver transplantationFavorable OSFemale predominanceMedian ageSurgical treatmentMultifocal diseaseRetrospective reviewTreatment optionsLarge tumorsClinical behaviorMayo Clinic