2014
Donor-Derived West Nile Virus Infection in Solid Organ Transplant Recipients
Winston DJ, Vikram HR, Rabe IB, Dhillon G, Mulligan D, Hong JC, Busuttil RW, Nowicki MJ, Mone T, Civen R, Tecle SA, Trivedi KK, Hocevar SN. Donor-Derived West Nile Virus Infection in Solid Organ Transplant Recipients. Transplantation 2014, 97: 881-889. PMID: 24827763, PMCID: PMC5765745, DOI: 10.1097/tp.0000000000000024.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsWest Nile virus infectionTransplant recipientsWNV infectionCerebrospinal fluidIntravenous immunoglobulinUnexplained feverWNV IgMVirus infectionRT-PCROrgan donorsWNV RNAReverse transcription polymerase chain reaction testingTranscription polymerase chain reaction testingSerological assaysPolymerase chain reaction testingReduction of immunosuppressionSymptomatic WNV infectionCommon clinical presentationOrgan transplant recipientsWNV activityFresh frozen plasmaPotential organ donorsConfirmation of infectionNeurologic deficits
2010
Nucleic Acid Testing (NAT) of Organ Donors: Is the ‘Best’ Test the Right Test? A Consensus Conference Report
Humar A, Morris M, Blumberg E, Freeman R, Preiksaitis J, Kiberd B, Schweitzer E, Ganz S, Caliendo A, Orlowski J, Wilson B, Kotton C, Michaels M, Kleinman S, Geier S, Murphy B, Green M, Levi M, Knoll G, Segev D, Brubaker S, Hasz R, Lebovitz D, Mulligan D, O’Connor K, Pruett T, Mozes M, Lee I, Delmonico F, Fischer S. Nucleic Acid Testing (NAT) of Organ Donors: Is the ‘Best’ Test the Right Test? A Consensus Conference Report. American Journal Of Transplantation 2010, 10: 889-899. PMID: 20121734, DOI: 10.1111/j.1600-6143.2009.02992.x.Peer-Reviewed Original ResearchConceptsNucleic acid testingOrgan donorsRisk factorsAcid testingInsufficient evidenceRoutine nucleic acid testingConsensus Conference reportDonor-derived infectionRisk of deathBehavioral risk factorsPotential organ donorsRisk of transmissionCandidate listingsHCV screeningDonor testingOrgan utilizationFalse-positive resultsOrgan offerProspective screeningDonor organsScreening modalityDonor lossWaiting listRapid turnaround timeTissue donors