2020
Lysis of cold‐storage‐induced microvascular obstructions for ex vivo revitalization of marginal human kidneys
DiRito JR, Hosgood SA, Reschke M, Albert C, Bracaglia LG, Ferdinand JR, Stewart BJ, Edwards CM, Vaish AG, Thiru S, Mulligan DC, Haakinson DJ, Clatworthy MR, Saltzman WM, Pober JS, Nicholson ML, Tietjen GT. Lysis of cold‐storage‐induced microvascular obstructions for ex vivo revitalization of marginal human kidneys. American Journal Of Transplantation 2020, 21: 161-173. PMID: 32627324, PMCID: PMC7775334, DOI: 10.1111/ajt.16148.Peer-Reviewed Original ResearchConceptsNormothermic machine perfusionHuman kidneyMicrovascular obstructionMarginal organsHigh-risk donorsSevere organ shortageLikelihood of complicationsMicrovascular blood flowAccumulation of fibrinogenCold storage injuryTissue plasminogen activatorImmediate translational potentialMicrovascular pluggingRenal functionRenal injuryMachine perfusionTubular epitheliumBlood flowIntravascular releaseOrgan shortagePhysiologic impactKidneyTranslational potentialPlasminogen activatorVivo assessment
2016
Simultaneous Liver–Kidney Allocation Policy: A Proposal to Optimize Appropriate Utilization of Scarce Resources
Formica R, Aeder M, Boyle G, Kucheryavaya A, Stewart D, Hirose R, Mulligan D. Simultaneous Liver–Kidney Allocation Policy: A Proposal to Optimize Appropriate Utilization of Scarce Resources. American Journal Of Transplantation 2016, 16: 758-766. PMID: 26603142, DOI: 10.1111/ajt.13631.Peer-Reviewed Original ResearchConceptsMayo End-Stage Liver Disease (MELD) scoreEnd-stage liver disease (MELD) scoreSimultaneous liver-kidney transplantKidney Donor Profile IndexConcurrent kidney transplantsLiver-kidney transplantLiver Disease scoreMedical Eligibility CriteriaLiver allocation policyOPTN Final RulePediatric recipientsKidney transplantRenal functionRenal insufficiencyUnited NetworkLiver candidatesTransplant communityDisease scoreOrgan donorsEligibility criteriaOrgan procurementTransplantation NetworkFinal ruleKidney allocationYoung adults
2010
Successful Transplantation of a Split Crossed Fused Ectopic Kidney into a Patient with End‐Stage Renal Disease
Mekeel KL, Daley SM, Andrews PE, Moss AA, Heilman RL, Mazur MJ, Chakkera HA, Hamawi K, Mulligan DC, Reddy K. Successful Transplantation of a Split Crossed Fused Ectopic Kidney into a Patient with End‐Stage Renal Disease. Journal Of Transplantation 2010, 2010: 383972. PMID: 20368777, PMCID: PMC2846343, DOI: 10.1155/2010/383972.Peer-Reviewed Original ResearchFused ectopic kidneyEctopic kidneySimultaneous kidney-pancreas transplantDeceased donor kidney transplantEnd-stage renal diseaseCongenital renal anomaliesKidney-pancreas transplantNormal renal functionDonor kidney transplantsPancreas transplantsKidney transplantRenal functionRenal diseaseParenchymal transectionRenal anomaliesSuccessful transplantationImmediate functionWaiting listTransplantPotential transplantsExcellent functionKidneyPotential donorsPatientsTransplantation
2009
Deceased Donor Kidney Transplantation from Donors with Acute Renal Failure due to Rhabdomyolysis
Mekeel KL, Moss AA, Mulligan DC, Chakkera HA, Hamawi K, Mazur MJ, Heilman RL, Reddy KS. Deceased Donor Kidney Transplantation from Donors with Acute Renal Failure due to Rhabdomyolysis. American Journal Of Transplantation 2009, 9: 1666-1670. PMID: 19459799, DOI: 10.1111/j.1600-6143.2009.02663.x.Peer-Reviewed Original ResearchConceptsAcute renal failureGraft functionRenal failureDeceased donor kidney transplantationFull renal functionGood graft functionSlow graft functionDelayed graft functionDonor kidney transplantationCreatinine kinase levelsUrine hemoglobinKidney transplantationMost patientsRenal functionMean creatinineDead patientsImmediate functionKinase levelsSolid organsTransplant communityOrgan donorsRhabdomyolysisPatientsGraftPotential donors
2007
Diffuse Parenchymal Urine Leak After Kidney Transplantation Following Degloving Injury During Donor Nephrectomy
Mekeel KL, Mazur MJ, Reddy KS, Mulligan DC, Heilman RL, Chakkera HA, Andrews PE, Moss AA. Diffuse Parenchymal Urine Leak After Kidney Transplantation Following Degloving Injury During Donor Nephrectomy. American Journal Of Transplantation 2007, 7: 2039-2041. PMID: 17578504, DOI: 10.1111/j.1600-6143.2007.01870.x.Peer-Reviewed Original ResearchConceptsDonor nephrectomyUrine leakRecipient graft functionGood renal functionLaparoscopic donor nephrectomyComplete deglovingGraft functionKidney transplantationPostoperative courseRenal functionPeritoneal windowLarge urinomaGlue treatmentKidneyUnconcentrated urineKidney surfaceNephrectomyLeakUrinomaPatientsTransplantationDeglovingInjuryTraumaUrine
1993
Baylor update: outcome analysis in liver transplantation.
Levy M, Goldstein R, Husberg B, Gonwa T, Backman L, Abouljoud M, Mulligan D, Klintmalm G. Baylor update: outcome analysis in liver transplantation. Clinical Transplants 1993, 161-73. PMID: 7918148.Peer-Reviewed Original ResearchConceptsLiver transplantationLong-term renal functionHepatitis B antigenemiaLate graft lossKaplan-Meier curvesGraft lossYear posttransplantLiver transplantElderly patientsRenal functionClinical correlatesOutcome analysisWhole bloodDisappointing resultsPlasma assaysPatientsTransplantationCurrent protocolsLife dataAntigenemiaPosttransplantDiabeticsCholangiocarcinomaTransplantBlood