2023
Honoring the gift: The transformative potential of transplant-declined human organs
Albert C, Harris M, DiRito J, Shi A, Edwards C, Harkins L, Lysyy T, Kulkarni S, Mulligan D, Hosgood S, Watson C, Friend P, Nicholson M, Haakinson D, Saeb-Parsy K, Tietjen G. Honoring the gift: The transformative potential of transplant-declined human organs. American Journal Of Transplantation 2023, 23: 165-170. PMID: 36695696, DOI: 10.1016/j.ajt.2022.11.015.Peer-Reviewed Original Research
2021
Inactive status is an independent predictor of liver transplant waitlist mortality and is associated with a transplant centers median meld at transplant
Merola J, Gan G, Stewart D, Noreen S, Mulligan D, Batra R, Haakinson D, Deng Y, Kulkarni S. Inactive status is an independent predictor of liver transplant waitlist mortality and is associated with a transplant centers median meld at transplant. PLOS ONE 2021, 16: e0260000. PMID: 34793524, PMCID: PMC8601542, DOI: 10.1371/journal.pone.0260000.Peer-Reviewed Original ResearchConceptsDonor service areasWaitlist mortalityTransplant centersMedian MELDHigh mortalityStatus changesLiver transplant waitlist mortalityDeceased donor transplantsInactive statusTransplant probabilityInactive patientsMELD scoreDonor transplantsHazard ratioIndependent predictorsTransplant ratesCare coordinationMortalityPatientsTransplantLevel cohortsTertileSignificant differencesCohortMELDDeveloping simultaneous liver‐kidney transplant medical eligibility criteria while providing a safety net: A 2‐year review of the OPTN's allocation policy
Wilk AR, Booker SE, Stewart DE, Wiseman A, Gauntt K, Mulligan D, Formica RN. Developing simultaneous liver‐kidney transplant medical eligibility criteria while providing a safety net: A 2‐year review of the OPTN's allocation policy. American Journal Of Transplantation 2021, 21: 3593-3607. PMID: 34254434, DOI: 10.1111/ajt.16761.Peer-Reviewed Original ResearchConceptsMedical Eligibility CriteriaEligibility criteriaLiver transplantPatient/graft survivalWaitlist mortality rateDeceased donor kidneysLiver recipientsSLK candidatesSLK transplantsGraft survivalRenal impairmentPosttransplant outcomesDonor kidneysTransplant ratesTransplant volumeMortality rateTransplantKidneySignificant differencesRecipientsSubsequent increaseLiver dataCriteriaImpairmentSLK
2018
Successful treatment of primary donor‐derived human herpesvirus‐8 infection and hepatic Kaposi Sarcoma in an adult liver transplant recipient
Fu W, Merola J, Malinis M, Lacy J, Barbieri A, Liapakis AH, Mulligan DC, Yoo PS. Successful treatment of primary donor‐derived human herpesvirus‐8 infection and hepatic Kaposi Sarcoma in an adult liver transplant recipient. Transplant Infectious Disease 2018, 20: e12966. PMID: 30014622, DOI: 10.1111/tid.12966.Peer-Reviewed Case Reports and Technical NotesConceptsHuman herpesvirus 8 infectionHepatic Kaposi sarcomaKaposi's sarcomaTransplant recipientsAdult liver transplant recipientsRegression of KSSplit liver transplantAcute cellular rejectionLiver transplant recipientsSuccessful therapeutic strategiesAllograft functionCellular rejectionLiver transplantSeropositive donorsSuccessful treatmentLiposomal doxorubicinTherapeutic strategiesRecipientsSarcomaInfectionTreatmentImmunosuppressionPatientsMalignancyTransplantRobotic Assisted Kidney Transplant, Reserved for the Deserved
Batra R, Mulligan D, Kulkarni S, Bhati C. Robotic Assisted Kidney Transplant, Reserved for the Deserved. Journal Of Clinical And Experimental Transplantation 2018, 3: 1-3. DOI: 10.4172/2475-7640.1000e104.Peer-Reviewed Original ResearchRobotic kidney transplantKidney transplantTransplant surgeryLower wound complicationsKidney transplant surgeryGeneral surgical proceduresOpen conventional surgeryMinimal invasive surgeryObese patientsWound complicationsPatient survivalPoor outcomeCertain patientsConventional surgerySurgical proceduresHigh incidenceObesity ratesTransplantSurgeryInvasive surgeryComplicationsObesityPatientsErgonomic advantagesGraft
2017
Inequity in organ allocation for patients awaiting liver transplantation: Rationale for uncapping the model for end-stage liver disease
Nadim MK, DiNorcia J, Ji L, Groshen S, Levitsky J, Sung RS, Kim WR, Andreoni K, Mulligan D, Genyk YS. Inequity in organ allocation for patients awaiting liver transplantation: Rationale for uncapping the model for end-stage liver disease. Journal Of Hepatology 2017, 67: 517-525. PMID: 28483678, PMCID: PMC7735955, DOI: 10.1016/j.jhep.2017.04.022.Peer-Reviewed Original ResearchConceptsEnd-stage liver diseaseLiver transplantMELD scoreLiver diseaseSick patientsLiver transplantationOrgan allocationEquitable organ distributionGreater MELD scoresPost-transplant outcomesOrgan Sharing dataPost-transplant survivalUnderwent liver transplantObjective scoring systemWaitlist registrationWaitlist mortalityHazard ratioSurvival benefitWaitlist candidatesUnited NetworkPatientsTransplantScoring systemMELDOrgan distribution
2016
Predicting Outcomes on the Liver Transplant Waiting List in the United States
Hart A, Schladt DP, Zeglin J, Pyke J, Kim WR, Lake JR, Roberts JP, Hirose R, Mulligan DC, Kasiske BL, Snyder JJ, Israni AK. Predicting Outcomes on the Liver Transplant Waiting List in the United States. Transplantation 2016, 100: 2153-2159. PMID: 27490411, PMCID: PMC5369025, DOI: 10.1097/tp.0000000000001384.Peer-Reviewed Original ResearchConceptsDonation service areaLiver transplantWaiting listEnd-stage liver disease (MELD) scoreLiver transplant waiting listTransplant Recipients databaseLiver Disease scoreMELD exception pointsTransplant waiting listAvailability of organsTransplant probabilityRecipients databasePatient characteristicsScientific RegistryTransplant programsUS adultsDisease scorePredicting OutcomeException pointsTransplantBlood typeOutcomesOngoing disparitiesCorresponding percentilesOnline calculatorDe Novo Belatacept in a Human Immunodeficiency Virus–Positive Kidney Transplant Recipient
Cohen E, Mulligan D, Kulkarni S, Tichy E. De Novo Belatacept in a Human Immunodeficiency Virus–Positive Kidney Transplant Recipient. American Journal Of Transplantation 2016, 16: 2753-2757. PMID: 27137752, DOI: 10.1111/ajt.13852.Peer-Reviewed Original ResearchConceptsRenal transplant recipientsTransplant recipientsHuman immunodeficiency virus–positive kidney transplant recipientHIV-positive renal transplant recipientsPositive renal transplant recipientsHIV-positive Black menActive antiretroviral agentsKidney transplant recipientsNew-onset diabetesHuman immunodeficiency virusImmunosuppressive regimensFirst transplantAntiretroviral agentsCalcineurin inhibitorsImmunodeficiency virusKidney donorsDrug interactionsTransplantRecipientsBlack menSuccessful casesDe novoBelataceptHypertensionHyperlipidemiaThe impact of broader regional sharing of livers: 2‐year results of “Share 35”
Edwards EB, Harper AM, Hirose R, Mulligan DC. The impact of broader regional sharing of livers: 2‐year results of “Share 35”. Liver Transplantation 2016, 22: 399-409. PMID: 26890858, DOI: 10.1002/lt.24418.Peer-Reviewed Original ResearchConceptsWaiting list mortalityLiver transplantLiver diseaseEnd-stage liver disease candidatesEnd-stage liver diseasePosttransplant survival outcomesChronic liver diseaseCold ischemia timeShare 35 policyRegional sharingBroader regional sharingPost-policy periodPosttransplant graftUrgent groupIschemia timePatient survivalSurvival outcomesMedian MELDMortality rateSickest candidatesOrgan procurementTransplantation NetworkTransplantAge groupsUrgent patients
2015
Non‐alcoholic fatty liver disease following liver transplantation: a clinical review
Merola J, Liapakis A, Mulligan DC, Yoo PS. Non‐alcoholic fatty liver disease following liver transplantation: a clinical review. Clinical Transplantation 2015, 29: 728-737. PMID: 26147308, DOI: 10.1111/ctr.12585.Peer-Reviewed Original ResearchConceptsNon-alcoholic steatohepatitisLiver transplantationRisk factorsNon-alcoholic fatty liver diseasePost-transplant metabolic syndromePost-transplant settingCardiovascular risk factorsPost-transplantation outcomesSignificant survival benefitFatty liver diseaseCause of deathCardiovascular mortalitySurvival benefitMetabolic syndromeLiver diseaseClinical reviewPatient populationSurgical approachTreatment approachesTransplantationRecent evidenceIndicationsSteatohepatitisTransplantSyndromeDisparity, Liver Demand, and Access to Transplants
Mulligan D. Disparity, Liver Demand, and Access to Transplants. American Journal Of Transplantation 2015, 15: 1746-1747. PMID: 25929170, DOI: 10.1111/ajt.13302.Peer-Reviewed Original ResearchEarly Changes in Liver Distribution Following Implementation of Share 35
Massie AB, Chow EK, Wickliffe CE, Luo X, Gentry SE, Mulligan DC, Segev DL. Early Changes in Liver Distribution Following Implementation of Share 35. American Journal Of Transplantation 2015, 15: 659-667. PMID: 25693474, PMCID: PMC6116537, DOI: 10.1111/ajt.13099.Peer-Reviewed Original ResearchConceptsDeceased donor liver transplantBaseline MELDShare 35Waitlist mortalityLiver distributionEarly posttransplant outcomesLower waitlist mortalityOdds of discardHandful of centersPosttransplant lengthLiver transplantPosttransplant mortalityPosttransplant outcomesEquivalent time periodMore transplantsEarly changesMELDMortalityPatientsTransplantMonthsEvidence of changes
2014
Written informed consent for living liver donor evaluation: Compliance with centers for medicare and medicaid services and organ procurement and transplantation network guidelines and alibi offers
Thiessen C, Kim YA, Yoo PS, Rodriguez‐Davalos M, Mulligan D, Kulkarni S. Written informed consent for living liver donor evaluation: Compliance with centers for medicare and medicaid services and organ procurement and transplantation network guidelines and alibi offers. Liver Transplantation 2014, 20: 416-424. PMID: 24415564, DOI: 10.1002/lt.23822.Peer-Reviewed Original Research
2012
Pretransplant Fasting Glucose Predicts New‐Onset Diabetes after Liver Transplantation
Carey EJ, Aqel BA, Byrne TJ, Douglas DD, Rakela J, Vargas HE, Moss AA, Mulligan DC, Reddy KS, Chakkera HA. Pretransplant Fasting Glucose Predicts New‐Onset Diabetes after Liver Transplantation. Journal Of Transplantation 2012, 2012: 614781. PMID: 22461975, PMCID: PMC3306927, DOI: 10.1155/2012/614781.Peer-Reviewed Original ResearchLiving-donor transplantsLiver transplant recipientsIncidence of NODATLiver transplantTransplant recipientsRisk factorsNew-onset diabetesLiver transplantationMELD scoreFasting GlucoseDL increasePoor outcomeMean ageNODATOnset diabetesHCVMultivariate analysisTransplantationTransplantFPGCorticosteroidsDiabetesPatientsIncidenceTwofold increase
2011
Mo1495 Anastomotic Biliary Strictures After Living Donor Liver Transplant: Ischemia Increases Recurrence Following Initial Endoscopic Treatment
Hsieh T, Harrison M, Crowell M, Mekeel K, Aqel B, Carey E, Byrne T, Vargas H, Douglas D, Rakela J, Reddy K, Moss A, Mulligan D. Mo1495 Anastomotic Biliary Strictures After Living Donor Liver Transplant: Ischemia Increases Recurrence Following Initial Endoscopic Treatment. Gastrointestinal Endoscopy 2011, 73: ab363-ab364. DOI: 10.1016/j.gie.2011.03.793.Peer-Reviewed Original Research
2010
ADVERSE IMPACT OF MILD HYPERTENSION POST TRANSPLANT ON 1 YEAR CHRONIC INTERSTIAL FIBROSIS AND TUBULAR ATROPY SCORES IN KIDNEY ALLOGRAFT BIOPSY AMONG A COHORT ON RAPID STEROID WITHDRAWL PROTOCOL.
Chakkera H, Devarapalli Y, Mulligan D, Mazur M, Hamawi K, Reddy K, Moss A, Mekeel K, Heilman R. ADVERSE IMPACT OF MILD HYPERTENSION POST TRANSPLANT ON 1 YEAR CHRONIC INTERSTIAL FIBROSIS AND TUBULAR ATROPY SCORES IN KIDNEY ALLOGRAFT BIOPSY AMONG A COHORT ON RAPID STEROID WITHDRAWL PROTOCOL. Transplantation 2010, 90: 387. DOI: 10.1097/00007890-201007272-00715.Peer-Reviewed Original ResearchSuccessful Transplantation of a Split Crossed Fused Ectopic Kidney into a Patient with End‐Stage Renal Disease
Mekeel KL, Daley SM, Andrews PE, Moss AA, Heilman RL, Mazur MJ, Chakkera HA, Hamawi K, Mulligan DC, Reddy K. Successful Transplantation of a Split Crossed Fused Ectopic Kidney into a Patient with End‐Stage Renal Disease. Journal Of Transplantation 2010, 2010: 383972. PMID: 20368777, PMCID: PMC2846343, DOI: 10.1155/2010/383972.Peer-Reviewed Original ResearchFused ectopic kidneyEctopic kidneySimultaneous kidney-pancreas transplantDeceased donor kidney transplantEnd-stage renal diseaseCongenital renal anomaliesKidney-pancreas transplantNormal renal functionDonor kidney transplantsPancreas transplantsKidney transplantRenal functionRenal diseaseParenchymal transectionRenal anomaliesSuccessful transplantationImmediate functionWaiting listTransplantPotential transplantsExcellent functionKidneyPotential donorsPatientsTransplantation
2008
Living donor liver transplantation in polycystic liver disease
Mekeel KL, Moss AA, Reddy KS, Douglas DD, Vargas HE, Carey EJ, Byrne TJ, Harrison ME, Rakela J, Mulligan DC. Living donor liver transplantation in polycystic liver disease. Liver Transplantation 2008, 14: 680-683. PMID: 18433036, DOI: 10.1002/lt.21423.Peer-Reviewed Original ResearchConceptsPolycystic liver diseaseDonor liver transplantationLiver transplantationLiver diseaseLiver functionEnd-Stage Liver Disease (MELD) systemDeceased donor liver transplantDonor liver transplantLiver transplantCaval resectionPoor qualityMassive hepatomegalyPatient survivalLiving donationPatientsHepatomegalyTransplantationHepatectomyDiseaseIdeal optionLDLTResectionComplicationsTransplantGraft
2005
Liver transplant in a patient with a ventriculoperitoneal shunt
Faybush E, Mulligan DC, Birch BD, Sirven JI, Balan V. Liver transplant in a patient with a ventriculoperitoneal shunt. Liver Transplantation 2005, 11: 467-468. PMID: 15776410, DOI: 10.1002/lt.20371.Peer-Reviewed Original ResearchConceptsVentriculoperitoneal shuntLiver transplantationNeurological complicationsTheoretical contraindicationGraft survivalLiver transplantMinor complicationsAccounts of patientsShunt conversionPatientsTransplantationComplicationsShuntNeurological perspectiveDeleterious effectsCirrhosisPosttransplantationVentriculoperitonealContraindicationsTransplantGraftInfection
2004
DIAGNOSIS AND ENDOSCOPIC TREATMENT OF ANASTOMOTIC BILIARY STRICTURES AFTER DECEASED DONOR LIVER TRANSPLANT
Harrison M, Nguyen C, Byrne T, Vargas H, Balan V, Douglas D, Moss A, Reddy K, Mulligan D, Rakela J. DIAGNOSIS AND ENDOSCOPIC TREATMENT OF ANASTOMOTIC BILIARY STRICTURES AFTER DECEASED DONOR LIVER TRANSPLANT. The American Journal Of Gastroenterology 2004, 99: s72-s73. DOI: 10.14309/00000434-200410001-00220.Peer-Reviewed Original Research