2023
Living Donor Liver Transplantation for Hepatocellular Carcinoma Within and Outside Traditional Selection Criteria
Ivanics T, Claasen M, Samstein B, Emond J, Fox A, Pomfret E, Pomposelli J, Tabrizian P, Florman S, Mehta N, Roberts J, Emamaullee J, Genyk Y, Hernandez-Alejandro R, Tomiyama K, Sasaki K, Hashimoto K, Nagai S, Abouljoud M, Olthoff K, Hoteit M, Heimbach J, Taner T, Liapakis A, Mulligan D, Sapisochin G, Halazun K, Group O. Living Donor Liver Transplantation for Hepatocellular Carcinoma Within and Outside Traditional Selection Criteria. Annals Of Surgery 2023, 279: 104-111. PMID: 37522174, DOI: 10.1097/sla.0000000000006049.Peer-Reviewed Original ResearchConceptsUniversity of California San FranciscoMilan criteriaDonor liver transplantationHepatocellular carcinomaOverall survivalLiver transplantationPosttransplantation survivalEvaluate long-term oncologic outcomesUniversity of California San Francisco criteriaLiving donor liver transplantationRecurrence-free survivalKaplan-Meier methodTransplant selection criteriaProportion of patientsAdult LDLT recipientsNorth American centersLong-term survivalLiver transplant waitlistCalifornia San FranciscoLDLT recipientsMulticenter cohortConsensus guidelinesTransplantationPatientsPosttransplantationLiving donor liver transplant candidate and donor selection and engagement: Meeting report from the living donor liver transplant consensus conference
Jesse M, Jackson W, Liapakis A, Ganesh S, Humar A, Goldaracena N, Levitsky J, Mulligan D, Pomfret E, Ladner D, Roberts J, Mavis A, Thiessen C, Trotter J, Winder G, Griesemer A, Pillai A, Kumar V, Verna E, Rudow D, Han H, Group T. Living donor liver transplant candidate and donor selection and engagement: Meeting report from the living donor liver transplant consensus conference. Clinical Transplantation 2023, 37: e14954. PMID: 36892182, DOI: 10.1111/ctr.14954.Peer-Reviewed Original ResearchConceptsDonor selectionConsensus conferenceDeceased donor organ shortageDonor liver transplantationLiver transplant candidatesDonor organ shortageLiver transplantationTransplant candidatesWaitlist mortalityExcellent outcomesLDLT candidatesOrgan shortageDonation outcomesLack of standardizationAmerican SocietyTransplantationDelphi approachBroad implementationMeeting reportOutcomesCandidate indicationsReportLDLTPatientsBroad uptakeHonoring the gift: The transformative potential of transplant-declined human organs
Albert C, Harris M, DiRito J, Shi A, Edwards C, Harkins L, Lysyy T, Kulkarni S, Mulligan D, Hosgood S, Watson C, Friend P, Nicholson M, Haakinson D, Saeb-Parsy K, Tietjen G. Honoring the gift: The transformative potential of transplant-declined human organs. American Journal Of Transplantation 2023, 23: 165-170. PMID: 36695696, DOI: 10.1016/j.ajt.2022.11.015.Peer-Reviewed Original Research
2021
Bile Microbiota in Liver Transplantation: Proof of Concept Using Gene Amplification in a Heterogeneous Clinical Scenario
D'Amico F, Bertacco A, Finotti M, Di Renzo C, Rodriguez-Davalos MI, Gondolesi GE, Cillo U, Mulligan D, Geibel J. Bile Microbiota in Liver Transplantation: Proof of Concept Using Gene Amplification in a Heterogeneous Clinical Scenario. Frontiers In Surgery 2021, 8: 621525. PMID: 33796547, PMCID: PMC8009296, DOI: 10.3389/fsurg.2021.621525.Peer-Reviewed Original ResearchBile microbiotaLiver donorsBiliary tract diseaseCommon bile ductGene amplificationRibosomal RNA gene amplificationLiver recipientsLiver transplantationPediatric recipientsLiver proceduresBiliary tractBile ductRecipient patientsTract diseaseBile samplesHeterogeneous cohortClinical scenariosBileSterile wayPCR sequencingPatientsRecipientsMicrobiotaTransplantationGallbladderThe demise of islet allotransplantation in the United States: A call for an urgent regulatory update
Witkowski P, Philipson L, Kaufman D, Ratner L, Abouljoud M, Bellin M, Buse J, Kandeel F, Stock P, Mulligan D, Markmann J, Kozlowski T, Andreoni K, Alejandro R, Baidal D, Hardy M, Wickrema A, Mirmira R, Fung J, Becker Y, Josephson M, Bachul P, Pyda J, Charlton M, Millis J, Gaglia J, Stratta R, Fridell J, Niederhaus S, Forbes R, Jayant K, Robertson R, Odorico J, Levy M, Harland R, Abrams P, Olaitan O, Kandaswamy R, Wellen J, Japour A, Desai C, Naziruddin B, Balamurugan A, Barth R, Ricordi C, Collaborative T. The demise of islet allotransplantation in the United States: A call for an urgent regulatory update. American Journal Of Transplantation 2021, 21: 1365-1375. PMID: 33251712, PMCID: PMC8016716, DOI: 10.1111/ajt.16397.Peer-Reviewed Original ResearchConceptsRegulatory frameworkUnited StatesIslet allotransplantationStandard-of-care procedureUS clinical practiceClinical practiceType 1 diabetes mellitusRegulatory distinctionsMinimally manipulated tissuesInvestigation proceduresRegulatory updatesClinical trialsBiological drugsDecades of progressPatientsAllotransplantationIslet transplantationTransplantationIsletsHuman isletsRegulationDrugHuman cellsImminent demiseState
2019
Frequency of whole-organ in lieu of split-liver transplantation over the last decade: Children experienced increased wait time and death
Valentino PL, Emre S, Geliang G, Li L, Deng Y, Mulligan D, Rodriguez-Davalos M. Frequency of whole-organ in lieu of split-liver transplantation over the last decade: Children experienced increased wait time and death. American Journal Of Transplantation 2019, 19: 3114-3123. PMID: 31152483, DOI: 10.1111/ajt.15481.Peer-Reviewed Original ResearchConceptsAdult recipientsTransplantation Network/United NetworkNumber of allograftsOrgan Sharing dataSplit-liver transplantationCareful patient selectionDeceased donor liversNumber of LTLT graftSLT recipientsUnderwent LTWLT recipientsPediatric candidatesPatient selectionDonor liversOrgan utilizationUnited NetworkOrgan shortageOrgan procurementSmall childrenRecipientsTransplantation
2018
American Society for Reproductive Medicine position statement on uterus transplantation: a committee opinion
Allyse M, Amer H, Coutifaris C, Falcone T, Famuyide A, Flyckt R, Gargiulo A, Heimbach J, Johannesson L, Jowsey-Gregoire S, Khan Z, Langstraat C, Levin S, McDiarmid S, Miller C, Mulligan D, O'Neill K, Penzias A, Pfeifer S, Porrett P, Quintini C, Reindollar R, Rosen C, Silasi D, Stewart E, Testa G, Tzakis A, Tullius S, Penzias A, Bendikson K, Falcone T, Gitlin S, Gracia C, Hansen K, Jindal S, Kalra S, Mersereau J, Odem R, Rebar R, Reindollar R, Rosen M, Sandlow J, Schlegel P, Stovall D. American Society for Reproductive Medicine position statement on uterus transplantation: a committee opinion. Fertility And Sterility 2018, 110: 605-610. PMID: 30196945, DOI: 10.1016/j.fertnstert.2018.06.017.Peer-Reviewed Original ResearchConceptsUterus transplantationAbsolute uterus factor infertilitySuccessful uterus transplantationSuccessful medical treatmentAmerican SocietyPatient advocacy groupsTransplanted uterusFactor infertilityMedical treatmentHealth professionalsSuccessful birthTransplantationCommittee OpinionReproductive medicinePosition statementFirst childRecent media reportsBirthAdvocacy groupsReportScientific reportsInfertilityUterus
2017
Liver allocation and distribution
Deshpande R, Hirose R, Mulligan D. Liver allocation and distribution. Current Opinion In Organ Transplantation 2017, 22: 162-168. PMID: 28212159, DOI: 10.1097/mot.0000000000000397.Peer-Reviewed Original ResearchConceptsTransplant CommitteeTransplant centersEnd-Stage Liver Disease (MELD) pointsLiver allograft allocationDeceased donor liversLife-saving organsLiver allocation policyAllograft allocationLiver transplantLiver transplantationLiver diseaseDonor liversUnited NetworkDonor organsLiver distributionAdvanced stageLiver allocationOrgan distributionPatient accessTransplantationGeographic disparitiesLiverDisease pointHealthcare systemPatients
2016
Partners in Crime: Kidney Transplantation and Seizure Disorder
Li N, Jean R, Tooley JE, Mulligan DC, Yoo PS. Partners in Crime: Kidney Transplantation and Seizure Disorder. Transplantation Proceedings 2016, 48: 2700-2708. PMID: 27788804, DOI: 10.1016/j.transproceed.2016.06.041.Peer-Reviewed Original ResearchConceptsKidney transplantationSeizure disorderClinical outcomesCommon neurologic complicationNational Inpatient SampleDisease-specific riskCost of careNeurologic complicationsClinical entityClinical complicationsInpatient SampleTransplantationHospitalization statisticsDisordersComplicationsRiskCareComplex management challengesFuture studiesOutcomesMortalityAttitudes toward organ donation among waitlisted transplant patients: results of a cross‐sectional survey
Merola J, Pei K, Rodriguez‐Davalos M, Gan G, Deng Y, Mulligan DC, Davis KA. Attitudes toward organ donation among waitlisted transplant patients: results of a cross‐sectional survey. Clinical Transplantation 2016, 30: 1449-1456. PMID: 27582432, PMCID: PMC5093046, DOI: 10.1111/ctr.12839.Peer-Reviewed Original ResearchConceptsCross-sectional surveyOrgan donationWaitlisted candidatesMinority of patientsDonor registration ratesDonation eligibilityTransplant patientsWaitlisted patientsPatients' willingnessGeneral populationOrgan donorsOrgan shortageMedical treatmentPatientsOrgan allocationDonation ratesTransplantationRegistration ratesDonationMajor barrierPopulationDonorsWaitlistPhysiciansDemographics
2015
Non‐alcoholic fatty liver disease following liver transplantation: a clinical review
Merola J, Liapakis A, Mulligan DC, Yoo PS. Non‐alcoholic fatty liver disease following liver transplantation: a clinical review. Clinical Transplantation 2015, 29: 728-737. PMID: 26147308, DOI: 10.1111/ctr.12585.Peer-Reviewed Original ResearchConceptsNon-alcoholic steatohepatitisLiver transplantationRisk factorsNon-alcoholic fatty liver diseasePost-transplant metabolic syndromePost-transplant settingCardiovascular risk factorsPost-transplantation outcomesSignificant survival benefitFatty liver diseaseCause of deathCardiovascular mortalitySurvival benefitMetabolic syndromeLiver diseaseClinical reviewPatient populationSurgical approachTreatment approachesTransplantationRecent evidenceIndicationsSteatohepatitisTransplantSyndrome
2012
A Consolidated Biovigilance System for Blood, Tissue and Organs: One Size Does Not Fit All
Pruett TL, Blumberg EA, Cohen DJ, Crippin JS, Freeman RB, Hanto DW, Mulligan DC, Green MD. A Consolidated Biovigilance System for Blood, Tissue and Organs: One Size Does Not Fit All. American Journal Of Transplantation 2012, 12: 1099-1101. PMID: 22487495, DOI: 10.1111/j.1600-6143.2011.03907.x.Peer-Reviewed Original ResearchConceptsOrgan transplant recipientsLimited organ availabilityPublic health servicesTransplant recipientsDonor testingOrgan availabilityWaiting listClinical practiceHealth servicesFormal recommendationsTransfer of organsDisease transmissionBloodOrgansOverall benefitTissueTransplantationSupport effortsRecipientsUreteral stricture formation in laparoscopically procured living donor kidney transplantation.
Tyson MD, Castle EP, Andrews PE, Heilman RL, Moss AA, Mulligan DC, Reddy KS. Ureteral stricture formation in laparoscopically procured living donor kidney transplantation. Canadian Journal Of Urology 2012, 19: 6188-92. PMID: 22512964.Peer-Reviewed Original ResearchConceptsUreteral stricture formationDelayed graft functionDonor kidney transplantationUreteral strictureGraft functionStricture formationUreteral stentsKidney transplantationStricture diseaseMultivariable logistic regression modelUreteral stricture diseaseLogistic regression modelsStricture groupRetrospective reviewProcedural interventionRisk factorsIntraoperative placementStrictureDonor databasePatientsIncidenceStentsTransplantationDiseaseRegression modelsPretransplant Fasting Glucose Predicts New‐Onset Diabetes after Liver Transplantation
Carey EJ, Aqel BA, Byrne TJ, Douglas DD, Rakela J, Vargas HE, Moss AA, Mulligan DC, Reddy KS, Chakkera HA. Pretransplant Fasting Glucose Predicts New‐Onset Diabetes after Liver Transplantation. Journal Of Transplantation 2012, 2012: 614781. PMID: 22461975, PMCID: PMC3306927, DOI: 10.1155/2012/614781.Peer-Reviewed Original ResearchLiving-donor transplantsLiver transplant recipientsIncidence of NODATLiver transplantTransplant recipientsRisk factorsNew-onset diabetesLiver transplantationMELD scoreFasting GlucoseDL increasePoor outcomeMean ageNODATOnset diabetesHCVMultivariate analysisTransplantationTransplantFPGCorticosteroidsDiabetesPatientsIncidenceTwofold increase
2011
Resolution of Long-Standing Necrobiosis Lipoidica Diabeticorum (NLD) Lesion After Restoration of Euglycemia Following Successful Pancreas After Kidney (PAK) Transplantation: A Case Report
Mazur M, Lowney A, Prigoff J, Heilman R, Chakkera H, Moss A, Mulligan D, Reddy K, Hamawi K. Resolution of Long-Standing Necrobiosis Lipoidica Diabeticorum (NLD) Lesion After Restoration of Euglycemia Following Successful Pancreas After Kidney (PAK) Transplantation: A Case Report. Transplantation Proceedings 2011, 43: 3296-3298. PMID: 22099781, DOI: 10.1016/j.transproceed.2011.10.005.Peer-Reviewed Original ResearchConceptsNecrobiosis lipoidica diabeticorumKidney transplantationPancreas transplantationType I diabetic recipientsTight diabetic controlInflammatory skin disorderRestoration of euglycemiaSuccessful pancreasDiabetic controlDiabetes mellitusDiabetic recipientsImmunosuppressive agentsCase reportUnknown causeCase of resolutionConsistent efficacySkin disordersTransplantationEuglycemiaPatientsPancreasTreatmentImmunosuppressionMellitusRegimenA Technique for Kidney Retransplantation After Simultaneous Kidney Pancreas Transplantation
Mekeel KL, Moss AA, Mulligan DC, Reddy KS. A Technique for Kidney Retransplantation After Simultaneous Kidney Pancreas Transplantation. Transplantation Proceedings 2011, 43: 1627-1628. PMID: 21693246, DOI: 10.1016/j.transproceed.2011.03.026.Peer-Reviewed Original ResearchEndoscopic Treatment of Anastomotic Biliary Strictures After Living Donor Liver Transplantation: Outcomes After Maximal Stent Therapy
Hsieh T, Harrison M, Crowell M, Mekeel K, Aqel B, Carey E, Byrne T, Vargas H, Douglas D, Rakela J, Reddy K, Moss A, Mulligan D. Endoscopic Treatment of Anastomotic Biliary Strictures After Living Donor Liver Transplantation: Outcomes After Maximal Stent Therapy. Clinical Gastroenterology And Hepatology 2011, 9: 184. DOI: 10.1016/j.cgh.2010.11.016.Peer-Reviewed Original Research
2010
What Hepatologists Should Know about Liver Transplant Surgery
Mekeel K, Mulligan D. What Hepatologists Should Know about Liver Transplant Surgery. 2010, 305-316. DOI: 10.1002/9781444325249.ch30.Peer-Reviewed Original ResearchLiver transplantationExcellent long-term patient outcomesLong-term patient outcomesDonor liver transplantationLiver transplant surgeryBiliary complicationsDonor allograftsMultidisciplinary careSurgical outcomesTransplant surgeryDonor poolPatient outcomesTransplant operationHepatic anatomyPhysiologic eventsHepatologistsComplicationsPatientsTransplantationOutcomesAllograftsSurgeryHepatectomyDiagnosisCareSuccessful Transplantation of a Split Crossed Fused Ectopic Kidney into a Patient with End‐Stage Renal Disease
Mekeel KL, Daley SM, Andrews PE, Moss AA, Heilman RL, Mazur MJ, Chakkera HA, Hamawi K, Mulligan DC, Reddy K. Successful Transplantation of a Split Crossed Fused Ectopic Kidney into a Patient with End‐Stage Renal Disease. Journal Of Transplantation 2010, 2010: 383972. PMID: 20368777, PMCID: PMC2846343, DOI: 10.1155/2010/383972.Peer-Reviewed Original ResearchFused ectopic kidneyEctopic kidneySimultaneous kidney-pancreas transplantDeceased donor kidney transplantEnd-stage renal diseaseCongenital renal anomaliesKidney-pancreas transplantNormal renal functionDonor kidney transplantsPancreas transplantsKidney transplantRenal functionRenal diseaseParenchymal transectionRenal anomaliesSuccessful transplantationImmediate functionWaiting listTransplantPotential transplantsExcellent functionKidneyPotential donorsPatientsTransplantation
2009
Living donor liver transplantation and donor graft size: How small can we go to reduce risk to the donor and what is the cost to the recipient?
Mulligan D. Living donor liver transplantation and donor graft size: How small can we go to reduce risk to the donor and what is the cost to the recipient? Liver Transplantation 2009, 15: 1392-1394. PMID: 19877257, DOI: 10.1002/lt.21922.Peer-Reviewed Original Research