2022
Epidemiology and outcomes of surgical site infections among pediatric liver transplant recipients
Banach DB, Lopez‐Verdugo F, Sanchez‐Garcia J, Tran A, Gomez‐Llerena A, Munoz‐Abraham A, Bertacco A, Valentino PL, Yoo P, Dembry L, Mulligan DC, Ekong UD, Emre SH, Rodriguez‐Davalos M. Epidemiology and outcomes of surgical site infections among pediatric liver transplant recipients. Transplant Infectious Disease 2022, 24: e13941. PMID: 35989545, DOI: 10.1111/tid.13941.Peer-Reviewed Original ResearchConceptsSurgical site infectionLiver transplant recipientsLiver transplantationBiliary complicationsGraft recipientsTransplant recipientsSite infectionRisk factorsOutcomes of SSIPediatric liver transplant recipientsLong-term graftPediatric liver transplantationRetrospective descriptive analysisPrimary endpointHospital daysPatient agePediatric populationPatient survivalSignificant causeComplicationsPatientsRecipientsOutcomesInfectionIncidence
2021
Developing simultaneous liver‐kidney transplant medical eligibility criteria while providing a safety net: A 2‐year review of the OPTN's allocation policy
Wilk AR, Booker SE, Stewart DE, Wiseman A, Gauntt K, Mulligan D, Formica RN. Developing simultaneous liver‐kidney transplant medical eligibility criteria while providing a safety net: A 2‐year review of the OPTN's allocation policy. American Journal Of Transplantation 2021, 21: 3593-3607. PMID: 34254434, DOI: 10.1111/ajt.16761.Peer-Reviewed Original ResearchConceptsMedical Eligibility CriteriaEligibility criteriaLiver transplantPatient/graft survivalWaitlist mortality rateDeceased donor kidneysLiver recipientsSLK candidatesSLK transplantsGraft survivalRenal impairmentPosttransplant outcomesDonor kidneysTransplant ratesTransplant volumeMortality rateTransplantKidneySignificant differencesRecipientsSubsequent increaseLiver dataCriteriaImpairmentSLK
2019
Frequency of whole-organ in lieu of split-liver transplantation over the last decade: Children experienced increased wait time and death
Valentino PL, Emre S, Geliang G, Li L, Deng Y, Mulligan D, Rodriguez-Davalos M. Frequency of whole-organ in lieu of split-liver transplantation over the last decade: Children experienced increased wait time and death. American Journal Of Transplantation 2019, 19: 3114-3123. PMID: 31152483, DOI: 10.1111/ajt.15481.Peer-Reviewed Original ResearchConceptsAdult recipientsTransplantation Network/United NetworkNumber of allograftsOrgan Sharing dataSplit-liver transplantationCareful patient selectionDeceased donor liversNumber of LTLT graftSLT recipientsUnderwent LTWLT recipientsPediatric candidatesPatient selectionDonor liversOrgan utilizationUnited NetworkOrgan shortageOrgan procurementSmall childrenRecipientsTransplantation
2017
Predictors of Waitlist Mortality in Portopulmonary Hypertension
DuBrock HM, Goldberg DS, Sussman NL, Bartolome SD, Kadry Z, Salgia RJ, Mulligan DC, Kremers WK, Kawut SM, Krowka MJ, Channick RN. Predictors of Waitlist Mortality in Portopulmonary Hypertension. Transplantation 2017, 101: 1609-1615. PMID: 28207639, PMCID: PMC5481480, DOI: 10.1097/tp.0000000000001666.Peer-Reviewed Original ResearchMeSH KeywordsArterial PressureCause of DeathChi-Square DistributionDatabases, FactualDecision Support TechniquesFemaleHumansHypertension, PortalHypertension, PulmonaryKaplan-Meier EstimateLiver DiseasesLiver TransplantationMaleMiddle AgedMultivariate AnalysisPortal PressurePredictive Value of TestsProportional Hazards ModelsPulmonary ArteryPulmonary CirculationRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTissue and Organ ProcurementTreatment OutcomeVascular ResistanceWaiting ListsConceptsPortopulmonary hypertensionWaitlist mortalityMELD exceptionsLiver diseaseException scoreEnd-Stage Liver Disease (MELD) exception pointsSignificant predictorsCox proportional hazards modelMELD exception scoreWaitlist mortality riskRetrospective cohort studyPulmonary arterial pressureTransplantation Network databaseSignificant univariate predictorsOnly significant univariate predictorsProportional hazards modelMELD scorePosttransplant mortalityPulmonary hypertensionCohort studyArterial pressureUnivariate predictorsC-statisticMortality riskHazards model
2015
Non‐alcoholic fatty liver disease following liver transplantation: a clinical review
Merola J, Liapakis A, Mulligan DC, Yoo PS. Non‐alcoholic fatty liver disease following liver transplantation: a clinical review. Clinical Transplantation 2015, 29: 728-737. PMID: 26147308, DOI: 10.1111/ctr.12585.Peer-Reviewed Original ResearchConceptsNon-alcoholic steatohepatitisLiver transplantationRisk factorsNon-alcoholic fatty liver diseasePost-transplant metabolic syndromePost-transplant settingCardiovascular risk factorsPost-transplantation outcomesSignificant survival benefitFatty liver diseaseCause of deathCardiovascular mortalitySurvival benefitMetabolic syndromeLiver diseaseClinical reviewPatient populationSurgical approachTreatment approachesTransplantationRecent evidenceIndicationsSteatohepatitisTransplantSyndrome
2012
Polyomavirus JC Urinary Shedding in Kidney and Liver Transplant Recipients Associated With Reduced Creatinine Clearance
Kusne S, Vilchez RA, Zanwar P, Quiroz J, Mazur MJ, Heilman RL, Mulligan D, Butel JS. Polyomavirus JC Urinary Shedding in Kidney and Liver Transplant Recipients Associated With Reduced Creatinine Clearance. The Journal Of Infectious Diseases 2012, 206: 875-880. PMID: 22802433, PMCID: PMC3501156, DOI: 10.1093/infdis/jis469.Peer-Reviewed Original ResearchConceptsJohn Cunningham virusSolid organ transplant recipientsLiver transplant recipientsOrgan transplant recipientsTransplant recipientsBK virusTransplant patientsUrinary sheddingKidney recipientsCreatinine clearanceReduced creatinine clearanceKidney transplant patientsLiver transplant patientsOrgan transplant patientsPolyomavirus BK virusJCV loadLiver recipientsPolyomavirus reactivationRenal dysfunctionSignificant morbidityPatient groupCrCl valuesLiver patientsPatientsKidneyUreteral stricture formation in laparoscopically procured living donor kidney transplantation.
Tyson MD, Castle EP, Andrews PE, Heilman RL, Moss AA, Mulligan DC, Reddy KS. Ureteral stricture formation in laparoscopically procured living donor kidney transplantation. Canadian Journal Of Urology 2012, 19: 6188-92. PMID: 22512964.Peer-Reviewed Original ResearchConceptsUreteral stricture formationDelayed graft functionDonor kidney transplantationUreteral strictureGraft functionStricture formationUreteral stentsKidney transplantationStricture diseaseMultivariable logistic regression modelUreteral stricture diseaseLogistic regression modelsStricture groupRetrospective reviewProcedural interventionRisk factorsIntraoperative placementStrictureDonor databasePatientsIncidenceStentsTransplantationDiseaseRegression models
2011
A randomized, multicenter study comparing steroid‐free immunosuppression and standard immunosuppression for liver transplant recipients with chronic hepatitis C
Klintmalm GB, Davis GL, Teperman L, Netto GJ, Washburn K, Rudich SM, Pomfret EA, Vargas HE, Brown R, Eckhoff D, Pruett TL, Roberts J, Mulligan DC, Charlton MR, Heffron TG, Ham JM, Douglas DD, Sher L, Baliga PK, Kinkhabwala M, Koneru B, Abecassis M, Millis M, Jennings LW, Fasola CG. A randomized, multicenter study comparing steroid‐free immunosuppression and standard immunosuppression for liver transplant recipients with chronic hepatitis C. Liver Transplantation 2011, 17: 1394-1403. PMID: 21850690, DOI: 10.1002/lt.22417.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex HormonesAntibodies, Monoclonal, HumanizedAntiviral AgentsBiopsyChi-Square DistributionDaclizumabDrug Therapy, CombinationFemaleGraft RejectionHepacivirusHepatitis C, ChronicHumansImmunoglobulin GImmunosuppressive AgentsKaplan-Meier EstimateLiver FailureLiver TransplantationMaleMiddle AgedMycophenolic AcidProportional Hazards ModelsProspective StudiesRecurrenceRisk AssessmentRisk FactorsRNA, ViralSurvival RateTacrolimusTime FactorsTreatment OutcomeUnited StatesConceptsAcute cellular rejectionSteroid-free immunosuppressionLiver transplant recipientsHCV recurrenceMycophenolate mofetilTransplant recipientsHCV RNA-positive subjectsHepatitis C virus infectionSevere HCV recurrenceSteroid-free groupC virus infectionChronic hepatitis CGraft survival ratesProportion of patientsLiver biopsy samplesCellular rejectionChronic HCVStandard immunosuppressionSteroid sparingHepatitis CLess diabetesMulticenter trialMulticenter studyPatient survivalArm 1Monoclonal Gammopathy of Undetermined Significance Does Not Affect Outcomes in Patients Undergoing Solid Organ Transplants
Jimenez-Zepeda VH, Heilman RL, Engel RA, Carey EJ, Freeman C, Rakela J, Mulligan DC, Fonseca R, Stewart AK. Monoclonal Gammopathy of Undetermined Significance Does Not Affect Outcomes in Patients Undergoing Solid Organ Transplants. Transplantation 2011, 92: 570-574. PMID: 21712755, DOI: 10.1097/tp.0b013e318225db2c.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBlood Protein ElectrophoresisChildDisease ProgressionFemaleHumansImmunosuppression TherapyLymphoproliferative DisordersMaleMiddle AgedMonoclonal Gammopathy of Undetermined SignificanceMultiple MyelomaRisk FactorsTransplantation ImmunologyTransplantsTreatment OutcomeYoung AdultConceptsSolid organ transplant patientsPosttransplant lymphoproliferative disorderOrgan transplant patientsTransplant patientsLymphoproliferative disordersMultiple myelomaUndetermined significanceMonoclonal gammopathyPlasma cell proliferative disorderLiver transplant candidatesOutcomes of patientsCase of progressionSolid organ transplantsPlasma cell dyscrasiaCell proliferative disorderMGUS patientsTransplant candidatesClinical courseLate malignancyLifelong riskImmune suppressionRelative riskCell dyscrasiaMonoclonal clonesOrgan transplantsPretransplant Risk Score for New-Onset Diabetes After Kidney Transplantation
Chakkera HA, Weil EJ, Swanson CM, Dueck AC, Heilman RL, Reddy KS, Hamawi K, Khamash H, Moss AA, Mulligan DC, Katariya N, Knowler WC. Pretransplant Risk Score for New-Onset Diabetes After Kidney Transplantation. Diabetes Care 2011, 34: 2141-2145. PMID: 21949218, PMCID: PMC3177751, DOI: 10.2337/dc11-0752.Peer-Reviewed Original ResearchConceptsRisk of NODATNew-onset diabetesRisk scoreKidney transplantationPretransplant variablesSingle-center retrospective cohort studyUnivariate logistic regression analysisMultivariate logistic regression modelRetrospective cohort studySimple risk scoreLogistic regression analysisLogistic regression modelsRelevant cut pointsYear posttransplantCohort studySerum glucoseNODATSummary scoresIntervention studiesDiabetesMultivariate modelCut pointsSum of pointsScoresRegression analysis
2010
Hepatic epithelioid haemangioendothelioma: is transplantation the only treatment option?
Grotz TE, Nagorney D, Donohue J, Que F, Kendrick M, Farnell M, Harmsen S, Mulligan D, Nguyen J, Rosen C, Reid-Lombardo K. Hepatic epithelioid haemangioendothelioma: is transplantation the only treatment option? Hepato Pancreato Biliary 2010, 12: 546-553. PMID: 20887322, PMCID: PMC2997660, DOI: 10.1111/j.1477-2574.2010.00213.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntineoplastic AgentsChi-Square DistributionDisease-Free SurvivalFemaleHemangioendothelioma, EpithelioidHepatectomyHumansKaplan-Meier EstimateLiver NeoplasmsLiver TransplantationMaleMiddle AgedPalliative CareProportional Hazards ModelsRetrospective StudiesRisk AssessmentRisk FactorsSurvival RateTime FactorsTreatment OutcomeUnited StatesYoung AdultConceptsHepatic epithelioid haemangioendotheliomaOrthotopic liver transplantationDisease-free survivalLiver resectionOverall survivalPrognostic factorsFavorable prognostic factorUnfavourable prognostic factorOnly treatment optionUnpredictable clinical behaviorRare vascular neoplasmResectable diseaseUnresectable diseaseEpithelioid haemangioendotheliomaLiver transplantationFavorable OSFemale predominanceMedian ageSurgical treatmentMultifocal diseaseRetrospective reviewTreatment optionsLarge tumorsClinical behaviorMayo ClinicEarly Graft Function After Laparoscopically Procured Living Donor Kidney Transplantation
Tyson M, Castle E, Andrews P, Heilman R, Mekeel K, Moss A, Mulligan D, Reddy K. Early Graft Function After Laparoscopically Procured Living Donor Kidney Transplantation. Journal Of Urology 2010, 184: 1434-1439. PMID: 20727548, DOI: 10.1016/j.juro.2010.06.013.Peer-Reviewed Original ResearchConceptsPoor early graft functionEarly graft functionLiving-donor kidney transplantationGraft functionDonor kidney transplantationAcute rejectionKidney transplantationMultivariate logistic regression modelGraft function groupDelayed graft functionDonor kidney transplantsInstitutional review boardLogistic regression modelsAllograft survivalGraft nephrectomyVascular complicationsKidney transplantPerioperative parametersIndependent predictorsTransplantation databaseClinical outcomesPatient survivalBlack ethnicityMale genderDonor ageRelationship between Inpatient Hyperglycemia and Insulin Treatment after Kidney Transplantation and Future New Onset Diabetes Mellitus
Chakkera HA, Knowler WC, Devarapalli Y, Weil EJ, Heilman RL, Dueck A, Mulligan DC, Reddy KS, Moss AA, Mekeel KL, Mazur MJ, Hamawi K, Castro JC, Cook CB. Relationship between Inpatient Hyperglycemia and Insulin Treatment after Kidney Transplantation and Future New Onset Diabetes Mellitus. Clinical Journal Of The American Society Of Nephrology 2010, 5: 1669-1675. PMID: 20558559, PMCID: PMC2974410, DOI: 10.2215/cjn.09481209.Peer-Reviewed Original ResearchConceptsKidney transplant recipientsInpatient hyperglycemiaKidney transplantationTransplant recipientsInsulin therapyNondiabetic kidney transplant recipientsDevelopment of NODATRisk of NODATNew-onset diabetesKidney transplant surgeryCapillary blood glucoseNondiabetic patientsYear posttransplantCardiovascular eventsNew onsetDiabetes mellitusMedical therapyAdjusted analysisStudy cohortRetrospective studyTransplant surgeryBlood glucoseSerum glucoseInsulin treatmentNODAT
2009
Pilot Study: Association of Traditional and Genetic Risk Factors and New-Onset Diabetes Mellitus Following Kidney Transplantation
Chakkera HA, Hanson RL, Raza SM, DiStefano JK, Millis MP, Heilman RL, Mulligan DC, Reddy KS, Mazur MJ, Hamawi K, Moss AA, Mekeel KL, Cerhan JR. Pilot Study: Association of Traditional and Genetic Risk Factors and New-Onset Diabetes Mellitus Following Kidney Transplantation. Transplantation Proceedings 2009, 41: 4172-4177. PMID: 20005362, PMCID: PMC3478878, DOI: 10.1016/j.transproceed.2009.08.063.Peer-Reviewed Original ResearchConceptsNew-onset diabetes mellitusDiabetes mellitusRisk factorsKidney transplantationTransplant recipientsFamily historyType 2 diabetes mellitusDevelopment of NODATKidney transplant recipientsTraditional risk factorsGenetic polymorphismsPositive family historyCommon risk factorsGenetic risk factorsLogistic regression modelsNODAT developmentNODAT riskPretransplant obesityNew onsetKidney transplantStudy cohortInsulin secretionNODATT2DMMellitusNatural history of post–liver transplantation hepatitis C: A review of factors that may influence its course
Gallegos‐Orozco J, Yosephy A, Noble B, Aqel BA, Byrne TJ, Carey EJ, Douglas DD, Mulligan D, Moss A, de Petris G, Williams JW, Rakela J, Vargas HE. Natural history of post–liver transplantation hepatitis C: A review of factors that may influence its course. Liver Transplantation 2009, 15: 1872-1881. PMID: 19938138, DOI: 10.1002/lt.21954.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultBiopsyDisease ProgressionFemaleGraft RejectionHepatitis CHumansKaplan-Meier EstimateLiver CirrhosisLiver FailureLiver TransplantationLiving DonorsMaleMiddle AgedProportional Hazards ModelsRecurrenceRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeConceptsEnd-stage liver diseaseHCV-positive recipientsLiver transplantHepatocellular carcinomaHCV recurrenceAcute rejectionPatient survivalBiopsy-proven acute rejectionMedian age 53 yearsHistory of HCCAggressive HCV recurrenceEarly acute rejectionProtocol liver biopsiesSignificant HCV recurrenceAdult liver transplantsAdvanced donor ageAge 53 yearsAge 39 yearsDay of transplantationLong-term survivalElectronic medical recordsAvoidance of rejectionEvaluable populationRapid fibrosersHepatitis CLiving donor liver transplantation and donor graft size: How small can we go to reduce risk to the donor and what is the cost to the recipient?
Mulligan D. Living donor liver transplantation and donor graft size: How small can we go to reduce risk to the donor and what is the cost to the recipient? Liver Transplantation 2009, 15: 1392-1394. PMID: 19877257, DOI: 10.1002/lt.21922.Peer-Reviewed Original ResearchHyperglycemia during the Immediate Period after Kidney Transplantation
Chakkera HA, Weil EJ, Castro J, Heilman RL, Reddy KS, Mazur MJ, Hamawi K, Mulligan DC, Moss AA, Mekeel KL, Cosio FG, Cook CB. Hyperglycemia during the Immediate Period after Kidney Transplantation. Clinical Journal Of The American Society Of Nephrology 2009, 4: 853-859. PMID: 19339426, PMCID: PMC2666437, DOI: 10.2215/cjn.05471008.Peer-Reviewed Original ResearchConceptsNew-onset diabetesKidney transplantationPretransplantation diabetesHospital dischargeImmediate posttransplantation periodPrevalence of hypoglycemiaKidney transplant recipientsStress of surgeryShort-acting insulinEvidence of hyperglycemiaHospital stayImmunosuppression medicationsPharmacologic managementTransplant recipientsHospital phasePosttransplantation periodPharmacy databaseStudy cohortProspective studyTransient hyperglycemiaObservational studyMetabolic effectsHyperglycemiaPatientsTransplantationSclerosing peritonitis and mortality after liver transplantation
Mekeel K, Moss A, Reddy KS, Douglas D, Mulligan D. Sclerosing peritonitis and mortality after liver transplantation. Liver Transplantation 2009, 15: 435-439. PMID: 19326414, DOI: 10.1002/lt.21702.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal PainAdultAscitesBacterial InfectionsCholestasisEndoscopy, Digestive SystemFatal OutcomeHumansIntestinal ObstructionLiver DiseasesLiver TransplantationMaleMalnutritionMiddle AgedParacentesisPeritonitisReoperationRisk FactorsSclerosisTomography, X-Ray ComputedTreatment OutcomeVascular DiseasesConceptsLiver transplantationBowel obstructionRefractory ascitesBacterial peritonitisEnd-stage liver diseasePartial small bowel obstructionMassive refractory ascitesSmall bowel obstructionEpisodes of peritonitisSpontaneous bacterial peritonitisTime of transplantationAbdominal painBiliary obstructionLiver diseasePeritoneal dialysisInferior venaPeritoneal surfaceFibrous peelPeritonitisPatientsTransplantationAscitesObstructionComplicationsEpisodes
2006
Acute Rejection Risk in Kidney Transplant Recipients on Steroid-Avoidance Immunosuppression Receiving Induction With Either Antithymocyte Globulin or Basiliximab
Heilman RL, Reddy KS, Mazur MJ, Moss AA, Post DJ, Petrides S, Mulligan DC. Acute Rejection Risk in Kidney Transplant Recipients on Steroid-Avoidance Immunosuppression Receiving Induction With Either Antithymocyte Globulin or Basiliximab. Transplantation Proceedings 2006, 38: 1307-1313. PMID: 16797289, DOI: 10.1016/j.transproceed.2006.02.116.Peer-Reviewed Original ResearchConceptsBiopsy-proven acute rejectionSteroid avoidance immunosuppressionKidney transplant recipientsAntithymocyte globulinAcute rejectionTransplant recipientsMonths posttransplantationAcute rejection-free survivalType 1 diabetes mellitusRabbit antithymocyte globulinRejection-free survivalAcute rejection riskInduction therapyMaintenance immunosuppressionProtocol biopsiesRapid discontinuationMost patientsDiabetes mellitusMedian timeLower incidenceRejection riskBasiliximabImmunosuppressionDay 4Overall risk
1997
Abdominal Catastrophe: Visceral Injury as a Cause of Peritonitis in Patients Treated by Peritoneal Dialysis
Harwell C, Newman L, Cacho C, Mulligan D, Schulak J, Friedlander M. Abdominal Catastrophe: Visceral Injury as a Cause of Peritonitis in Patients Treated by Peritoneal Dialysis. Advances In Peritoneal Dialysis 1997, 17: 586-594. PMID: 9655159, DOI: 10.1177/089686089701700611.Peer-Reviewed Original ResearchConceptsPeritoneal dialysisAbdominal catastropheVisceral injuryFailure patientsEpisodes of PDNon-renal failure patientsTertiary care referral centerEnteric organismsIschemic bowel diseaseChronic peritoneal dialysisRetrospective chart reviewCause of peritonitisRenal failure patientsViscus perforationHospital courseChart reviewReferral centerRenal failureBacterial peritonitisBowel diseaseOverall incidenceSurgical interventionUniversity HospitalPeritonitisPatients