2003
Effects of tacrolimus on ischemia‐reperfusion injury
St. Peter SD, Moss AA, Mulligan DC. Effects of tacrolimus on ischemia‐reperfusion injury. Liver Transplantation 2003, 9: 105-116. PMID: 12548502, DOI: 10.1053/jlts.2003.50020.Peer-Reviewed Original ResearchConceptsEffects of tacrolimusIschemia-reperfusion injuryCellular mechanismsCalcium-activated pathwaysInteractions of tacrolimusFree radical metabolismCornerstone agentEfficacious immunosuppressionInflammatory cascadeOrgan transplantationTacrolimusCytoprotective effectsTissue recoveryClinical literatureDiverse actionsRadical metabolismImmunosuppressionInjuryMitochondrial stabilityStress response proteinsReperfusionIschemiaTransplantationTranscription factorsMicrocirculationTacrolimus as a liver flush solution to ameliorate the effects of ischemia/reperfusion injury following liver transplantation
St. Peter SD, Post DJ, Rodriguez‐Davalos M, Douglas DD, Moss AA, Mulligan DC. Tacrolimus as a liver flush solution to ameliorate the effects of ischemia/reperfusion injury following liver transplantation. Liver Transplantation 2003, 9: 144-149. PMID: 12548508, DOI: 10.1053/jlts.2003.50018.Peer-Reviewed Original ResearchConceptsIschemia/reperfusion injuryTacrolimus treatmentReperfusion injuryFlush solutionGroup 2Group 1Partial thromboplastin time valuesBaseline aspartate aminotransferaseEarly graft functionOrthotopic liver transplantProspective randomized fashionTotal ischemia timeSerum laboratory valuesSuperior early graft functionGraft functionLiver transplantLiver transplantationHepatic allograftsHepatocellular injuryLiver injuryPlacebo treatmentLiver diseasePlasma-Lyte AHepatocellular damageIschemia time
2002
Activation Time Course of Activator Protein-1 and Effect of Proline Dithiocarbamate During Ischemia-Reperfusion in Rat Skeletal Muscle
Lefler SR, Lille ST, Huemer G, Tucker R, Murray T, Schoeller T, Mulligan DC. Activation Time Course of Activator Protein-1 and Effect of Proline Dithiocarbamate During Ischemia-Reperfusion in Rat Skeletal Muscle. Annals Of Plastic Surgery 2002, 49: 654-659. PMID: 12461450, DOI: 10.1097/00000637-200212000-00016.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryAP-1 activationRat skeletal muscleActivator protein-1Nuclear factor-kappa B (NF-κB) inhibitorSkeletal muscleAP-1Hours of reperfusionProtein 1Proline dithiocarbamateIschemia reperfusionIschemic periodIntravenous administrationBiphasic patternB inhibitorReperfusionActivation time courseFurther elucidationTime courseInjuryExpression of genesPerfusionDeleterious effectsMuscleHoursAmelioration of hepatic ischemia/reperfusion injury using indolepropionic acid
Lefler SR, St. Peter SD, Rodriguez-Davalos MI, Perumean JC, Spence NA, Moss AA, Mulligan DC. Amelioration of hepatic ischemia/reperfusion injury using indolepropionic acid. Transplantation Proceedings 2002, 34: 3065-3066. PMID: 12493376, DOI: 10.1016/s0041-1345(02)03616-3.Peer-Reviewed Original Research
2001
Inhibition of the initial wave of NF‐κB activity in rat muscle reduces ischemia/reperfusion injury
Lille S, Lefler S, Mowlavi A, Suchy H, Boyle E, Farr A, Su C, Frank N, Mulligan D. Inhibition of the initial wave of NF‐κB activity in rat muscle reduces ischemia/reperfusion injury. Muscle & Nerve 2001, 24: 534-541. PMID: 11268026, DOI: 10.1002/mus.1037.Peer-Reviewed Original ResearchConceptsIschemia/reperfusion injuryNF-kappaB activationNF-kappaBReperfusion injurySevere ischemic stressNF-κB activityNuclear factor-kappaBRat skeletal muscleR injuryEarly reperfusionIschemic periodNeutrophil activityMuscle edemaIntravenous administrationIschemic stressReperfusionTherapeutic interventionsFactor-kappaBMuscle survivalIncreased percentageBiphasic patternInjurySkeletal muscleRat muscleActivity levels