2014
Magnetic resonance elastography can discriminate normal vs. abnormal liver biopsy in candidates for live liver donation
Gallegos-Orozco JF, Silva AC, Batheja MJ, Chang YH, Hansen KL, Lam-Himlin D, De Petris G, Aqel BA, Byrne TJ, Carey EJ, Douglas DD, Mulligan DC, Silva AM, Rakela J, Vargas HE. Magnetic resonance elastography can discriminate normal vs. abnormal liver biopsy in candidates for live liver donation. Abdominal Radiology 2014, 40: 795-802. PMID: 25445158, DOI: 10.1007/s00261-014-0310-y.Peer-Reviewed Original ResearchConceptsLive liver donationLiver biopsyLiver donationMagnetic resonance elastographyHepatic steatosisOptimal cutoffExact testPotential live liver donorsAbnormal liver biopsyAbnormal liver histologyLive liver donorsDegree of steatosisDonor evaluation processLiver biopsy resultsROC curveFisher's exact testLiver shear stiffnessAbility of MREResonance elastographyLiver histologyBiopsy resultsLiver donorsLiver fibrosisSteatosisBiopsy
2011
A randomized, multicenter study comparing steroid‐free immunosuppression and standard immunosuppression for liver transplant recipients with chronic hepatitis C
Klintmalm GB, Davis GL, Teperman L, Netto GJ, Washburn K, Rudich SM, Pomfret EA, Vargas HE, Brown R, Eckhoff D, Pruett TL, Roberts J, Mulligan DC, Charlton MR, Heffron TG, Ham JM, Douglas DD, Sher L, Baliga PK, Kinkhabwala M, Koneru B, Abecassis M, Millis M, Jennings LW, Fasola CG. A randomized, multicenter study comparing steroid‐free immunosuppression and standard immunosuppression for liver transplant recipients with chronic hepatitis C. Liver Transplantation 2011, 17: 1394-1403. PMID: 21850690, DOI: 10.1002/lt.22417.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex HormonesAntibodies, Monoclonal, HumanizedAntiviral AgentsBiopsyChi-Square DistributionDaclizumabDrug Therapy, CombinationFemaleGraft RejectionHepacivirusHepatitis C, ChronicHumansImmunoglobulin GImmunosuppressive AgentsKaplan-Meier EstimateLiver FailureLiver TransplantationMaleMiddle AgedMycophenolic AcidProportional Hazards ModelsProspective StudiesRecurrenceRisk AssessmentRisk FactorsRNA, ViralSurvival RateTacrolimusTime FactorsTreatment OutcomeUnited StatesConceptsAcute cellular rejectionSteroid-free immunosuppressionLiver transplant recipientsHCV recurrenceMycophenolate mofetilTransplant recipientsHCV RNA-positive subjectsHepatitis C virus infectionSevere HCV recurrenceSteroid-free groupC virus infectionChronic hepatitis CGraft survival ratesProportion of patientsLiver biopsy samplesCellular rejectionChronic HCVStandard immunosuppressionSteroid sparingHepatitis CLess diabetesMulticenter trialMulticenter studyPatient survivalArm 1
2010
Impact of Subclinical Inflammation on the Development of Interstitial Fibrosis and Tubular Atrophy in Kidney Transplant Recipients
Heilman RL, Devarapalli Y, Chakkera HA, Mekeel KL, Moss AA, Mulligan DC, Mazur MJ, Hamawi K, Williams JW, Reddy KS. Impact of Subclinical Inflammation on the Development of Interstitial Fibrosis and Tubular Atrophy in Kidney Transplant Recipients. American Journal Of Transplantation 2010, 10: 563-570. PMID: 20121731, DOI: 10.1111/j.1600-6143.2009.02966.x.Peer-Reviewed Original ResearchConceptsIF/TA scoreRapid steroid withdrawalSubclinical acute rejectionClinical acute rejectionSubclinical inflammationGroup 2Group 1Group 3Acute rejectionTubular atrophyInterstitial fibrosisGroup 4IF/TAProtocol biopsy findingsKidney transplant recipientsTA scoresProtocol biopsiesSteroid withdrawalTransplant recipientsBiopsy findingsInterstitial inflammationMore patientsMonths 1High riskPatients
2009
Natural history of post–liver transplantation hepatitis C: A review of factors that may influence its course
Gallegos‐Orozco J, Yosephy A, Noble B, Aqel BA, Byrne TJ, Carey EJ, Douglas DD, Mulligan D, Moss A, de Petris G, Williams JW, Rakela J, Vargas HE. Natural history of post–liver transplantation hepatitis C: A review of factors that may influence its course. Liver Transplantation 2009, 15: 1872-1881. PMID: 19938138, DOI: 10.1002/lt.21954.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultBiopsyDisease ProgressionFemaleGraft RejectionHepatitis CHumansKaplan-Meier EstimateLiver CirrhosisLiver FailureLiver TransplantationLiving DonorsMaleMiddle AgedProportional Hazards ModelsRecurrenceRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeConceptsEnd-stage liver diseaseHCV-positive recipientsLiver transplantHepatocellular carcinomaHCV recurrenceAcute rejectionPatient survivalBiopsy-proven acute rejectionMedian age 53 yearsHistory of HCCAggressive HCV recurrenceEarly acute rejectionProtocol liver biopsiesSignificant HCV recurrenceAdult liver transplantsAdvanced donor ageAge 53 yearsAge 39 yearsDay of transplantationLong-term survivalElectronic medical recordsAvoidance of rejectionEvaluable populationRapid fibrosersHepatitis CHemobilia and pancreatitis after liver transplant biopsy
Li F, Mekeel KL, Eleid M, Harrison ME, Reddy KS, Moss AA, Mulligan DC. Hemobilia and pancreatitis after liver transplant biopsy. Liver Transplantation 2009, 15: 350-351. PMID: 19243004, DOI: 10.1002/lt.21619.Peer-Reviewed Original Research
2007
Clinical factors associated with graft fibrosis in kidney‐transplant recipients on steroid‐avoidance immunosuppression
Heilman RL, Chakkera HA, Reddy KS, Colby TV, Moss AA, Williams JW, Mazur MJ, Petrides S, Mulligan DC. Clinical factors associated with graft fibrosis in kidney‐transplant recipients on steroid‐avoidance immunosuppression. Clinical Transplantation 2007, 22: 309-315. PMID: 18482051, DOI: 10.1111/j.1399-0012.2007.00786.x.Peer-Reviewed Original ResearchConceptsSteroid avoidance immunosuppressionKidney-pancreas transplant recipientsOne-year biopsyKidney transplant recipientsBK nephropathySerum creatinineProtocol biopsiesRecipient ageTransplant recipientsGraft fibrosisUnadjusted logistic regression analysisLower body mass indexMultivariate logistic regression modelCI scoresPrimary kidney transplantsPancreas transplant recipientsBody mass indexInterstitial cellular infiltrateLogistic regression analysisLogistic regression modelsAcute rejectionAntigen mismatchesAntithymocyte globulinGraft outcomeKidney transplant