2011
A randomized, multicenter study comparing steroid‐free immunosuppression and standard immunosuppression for liver transplant recipients with chronic hepatitis C
Klintmalm GB, Davis GL, Teperman L, Netto GJ, Washburn K, Rudich SM, Pomfret EA, Vargas HE, Brown R, Eckhoff D, Pruett TL, Roberts J, Mulligan DC, Charlton MR, Heffron TG, Ham JM, Douglas DD, Sher L, Baliga PK, Kinkhabwala M, Koneru B, Abecassis M, Millis M, Jennings LW, Fasola CG. A randomized, multicenter study comparing steroid‐free immunosuppression and standard immunosuppression for liver transplant recipients with chronic hepatitis C. Liver Transplantation 2011, 17: 1394-1403. PMID: 21850690, DOI: 10.1002/lt.22417.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex HormonesAntibodies, Monoclonal, HumanizedAntiviral AgentsBiopsyChi-Square DistributionDaclizumabDrug Therapy, CombinationFemaleGraft RejectionHepacivirusHepatitis C, ChronicHumansImmunoglobulin GImmunosuppressive AgentsKaplan-Meier EstimateLiver FailureLiver TransplantationMaleMiddle AgedMycophenolic AcidProportional Hazards ModelsProspective StudiesRecurrenceRisk AssessmentRisk FactorsRNA, ViralSurvival RateTacrolimusTime FactorsTreatment OutcomeUnited StatesConceptsAcute cellular rejectionSteroid-free immunosuppressionLiver transplant recipientsHCV recurrenceMycophenolate mofetilTransplant recipientsHCV RNA-positive subjectsHepatitis C virus infectionSevere HCV recurrenceSteroid-free groupC virus infectionChronic hepatitis CGraft survival ratesProportion of patientsLiver biopsy samplesCellular rejectionChronic HCVStandard immunosuppressionSteroid sparingHepatitis CLess diabetesMulticenter trialMulticenter studyPatient survivalArm 1
2005
Hepatic B‐cell non‐Hodgkin's lymphoma of MALT type in the liver explant of a patient with chronic hepatitis C infection
Orrego M, Guo L, Reeder C, De Petris G, Balan V, Douglas DD, Byrne T, Harrison E, Mulligan D, Rodriguez‐Luna H, Moss A, Reddy K, Rakela J, Vargas HE. Hepatic B‐cell non‐Hodgkin's lymphoma of MALT type in the liver explant of a patient with chronic hepatitis C infection. Liver Transplantation 2005, 11: 796-799. PMID: 15973702, DOI: 10.1002/lt.20384.Peer-Reviewed Original ResearchMeSH KeywordsHepatitis C, ChronicHumansIncidental FindingsLiver CirrhosisLiver FailureLiver NeoplasmsLymphoma, B-Cell, Marginal ZoneMaleMiddle AgedConceptsLiver transplantationHodgkin's lymphomaB cellsChronic hepatitis C infectionHepatitis C virus infectionHepatic B cellsC virus infectionHepatitis C infectionMarginal zone lymphomaC infectionCirrhotic patientsVirus infectionB-NHLLiver explantsMALT typeLymphomaClinical settingCommon typePatientsInfectionComplicationsTransplantation
2004
Hepatitis C Virus Infection with Hepatocellular Carcinoma: Not A Controversial Indication for Liver Transplantation
Rodriguez-Luna H, Balan V, Sharma P, Byrne T, Mulligan D, Rakela J, Vargas HE. Hepatitis C Virus Infection with Hepatocellular Carcinoma: Not A Controversial Indication for Liver Transplantation. Transplantation 2004, 78: 580-583. PMID: 15446318, DOI: 10.1097/01.tp.0000129797.30999.69.Peer-Reviewed Original ResearchConceptsHepatitis C virus infectionC virus infectionHepatocellular carcinomaHCV/Liver transplantationVirus infectionChronic hepatitis C virus (HCV) infectionSurvival rateChronic HCV infectionOrthotopic liver transplantationOutcomes of patientsOrgan Sharing dataHCC recurrence rateOverall survival rateLower survival rateHCV groupLT patientsHCV infectionHCC recurrencePatient survivalRecurrence rateUnited NetworkMean agePotential contraindicationsHCC groupHepatitis C Virus Quasi-Species Dynamics Predict Progression of Fibrosis after Liver Transplantation
Arenas JI, Gallegos-Orozco JF, Laskus T, Wilkinson J, Khatib A, Fasola C, Adair D, Radkowski M, Kibler KV, Nowicki M, Douglas D, Williams J, Netto G, Mulligan D, Klintmalm G, Rakela J, Vargas HE. Hepatitis C Virus Quasi-Species Dynamics Predict Progression of Fibrosis after Liver Transplantation. The Journal Of Infectious Diseases 2004, 189: 2037-2046. PMID: 15143471, DOI: 10.1086/386338.Peer-Reviewed Original ResearchMeSH Keywords5' Untranslated RegionsDisease ProgressionElectrophoresis, Polyacrylamide GelFemaleGenetic VariationHepacivirusHepatitis C, ChronicHumansLiver CirrhosisLiver TransplantationMaleMiddle AgedPhylogenyPolymorphism, Single-Stranded ConformationalReverse Transcriptase Polymerase Chain ReactionRNA, ViralViral Envelope ProteinsConceptsOrthotopic liver transplantationHepatitis C virusLiver transplantationGroup 1Quasi speciesSeverity of recurrenceGroup 1 patientsGroup 2 patientsE2 regionProgression of fibrosisPost-OLT periodCourse of infectionHeteroduplex mobility assayHCV complexityHCV infectionC virusGroup 2PatientsTransplantationSingle-strand conformational polymorphismLiver samplesInfectionWeeksQuasi-species dynamicsYears
2002
Detection of hepatitis C virus sequences in brain tissue obtained in recurrent hepatitis C after liver transplantation
Vargas HE, Laskus T, Radkowski M, Wilkinson J, Balan V, Douglas DD, Harrison ME, Mulligan DC, Olden K, Adair D, Rakela J. Detection of hepatitis C virus sequences in brain tissue obtained in recurrent hepatitis C after liver transplantation. Liver Transplantation 2002, 8: 1014-1019. PMID: 12424714, DOI: 10.1053/jlts.2002.36393.Peer-Reviewed Original ResearchConceptsHCV RNA negative strandRecurrent hepatitis CHepatitis CBrain tissueLiver transplantationHCV replicationSevere hepatitis C recurrenceHepatitis C virus replicationCholestatic fibrosing hepatitisHepatitis C recurrenceStrand-specific TthChronic hepatitis CChronic hepatitis C.Subcortical white matterC virus replicationReverse transcriptase-polymerase chain reactionCentral nervous systemHepatitis C virus sequencesC recurrenceMultiorgan failureHepatitis C.Easy fatigabilityCerebral cortexCerebral functionPolymerase chain reaction