2003
Effects of tacrolimus on ischemia‐reperfusion injury
St. Peter SD, Moss AA, Mulligan DC. Effects of tacrolimus on ischemia‐reperfusion injury. Liver Transplantation 2003, 9: 105-116. PMID: 12548502, DOI: 10.1053/jlts.2003.50020.Peer-Reviewed Original ResearchConceptsEffects of tacrolimusIschemia-reperfusion injuryCellular mechanismsCalcium-activated pathwaysInteractions of tacrolimusFree radical metabolismCornerstone agentEfficacious immunosuppressionInflammatory cascadeOrgan transplantationTacrolimusCytoprotective effectsTissue recoveryClinical literatureDiverse actionsRadical metabolismImmunosuppressionInjuryMitochondrial stabilityStress response proteinsReperfusionIschemiaTransplantationTranscription factorsMicrocirculation
2001
Inhibition of the initial wave of NF‐κB activity in rat muscle reduces ischemia/reperfusion injury
Lille S, Lefler S, Mowlavi A, Suchy H, Boyle E, Farr A, Su C, Frank N, Mulligan D. Inhibition of the initial wave of NF‐κB activity in rat muscle reduces ischemia/reperfusion injury. Muscle & Nerve 2001, 24: 534-541. PMID: 11268026, DOI: 10.1002/mus.1037.Peer-Reviewed Original ResearchConceptsIschemia/reperfusion injuryNF-kappaB activationNF-kappaBReperfusion injurySevere ischemic stressNF-κB activityNuclear factor-kappaBRat skeletal muscleR injuryEarly reperfusionIschemic periodNeutrophil activityMuscle edemaIntravenous administrationIschemic stressReperfusionTherapeutic interventionsFactor-kappaBMuscle survivalIncreased percentageBiphasic patternInjurySkeletal muscleRat muscleActivity levels