2023
Living donor liver transplant candidate and donor selection and engagement: Meeting report from the living donor liver transplant consensus conference
Jesse M, Jackson W, Liapakis A, Ganesh S, Humar A, Goldaracena N, Levitsky J, Mulligan D, Pomfret E, Ladner D, Roberts J, Mavis A, Thiessen C, Trotter J, Winder G, Griesemer A, Pillai A, Kumar V, Verna E, Rudow D, Han H, Group T. Living donor liver transplant candidate and donor selection and engagement: Meeting report from the living donor liver transplant consensus conference. Clinical Transplantation 2023, 37: e14954. PMID: 36892182, DOI: 10.1111/ctr.14954.Peer-Reviewed Original ResearchMeSH KeywordsConsensusDonor SelectionHumansLiver TransplantationLiving DonorsTissue and Organ ProcurementUnited StatesConceptsDonor selectionConsensus conferenceDeceased donor organ shortageDonor liver transplantationLiver transplant candidatesDonor organ shortageLiver transplantationTransplant candidatesWaitlist mortalityExcellent outcomesLDLT candidatesOrgan shortageDonation outcomesLack of standardizationAmerican SocietyTransplantationDelphi approachBroad implementationMeeting reportOutcomesCandidate indicationsReportLDLTPatientsBroad uptakeHonoring the gift: The transformative potential of transplant-declined human organs
Albert C, Harris M, DiRito J, Shi A, Edwards C, Harkins L, Lysyy T, Kulkarni S, Mulligan D, Hosgood S, Watson C, Friend P, Nicholson M, Haakinson D, Saeb-Parsy K, Tietjen G. Honoring the gift: The transformative potential of transplant-declined human organs. American Journal Of Transplantation 2023, 23: 165-170. PMID: 36695696, DOI: 10.1016/j.ajt.2022.11.015.Peer-Reviewed Original Research
2021
Developing simultaneous liver‐kidney transplant medical eligibility criteria while providing a safety net: A 2‐year review of the OPTN's allocation policy
Wilk AR, Booker SE, Stewart DE, Wiseman A, Gauntt K, Mulligan D, Formica RN. Developing simultaneous liver‐kidney transplant medical eligibility criteria while providing a safety net: A 2‐year review of the OPTN's allocation policy. American Journal Of Transplantation 2021, 21: 3593-3607. PMID: 34254434, DOI: 10.1111/ajt.16761.Peer-Reviewed Original ResearchMeSH KeywordsAdultGraft SurvivalHumansKidneyKidney TransplantationLiverLiver TransplantationPolicyRisk FactorsTissue and Organ ProcurementConceptsMedical Eligibility CriteriaEligibility criteriaLiver transplantPatient/graft survivalWaitlist mortality rateDeceased donor kidneysLiver recipientsSLK candidatesSLK transplantsGraft survivalRenal impairmentPosttransplant outcomesDonor kidneysTransplant ratesTransplant volumeMortality rateTransplantKidneySignificant differencesRecipientsSubsequent increaseLiver dataCriteriaImpairmentSLKImpact of the new heart allocation policy on patients with restrictive, hypertrophic, or congenital cardiomyopathies
Chouairi F, Mullan CW, Sen S, Mori M, Fuery M, Elder RW, Lesse J, Norton K, Clark KA, Miller PE, Mulligan D, Formica R, Rogers JG, Jacoby D, Maulion C, Anwer M, Geirsson A, Desai NR, Ahmad T. Impact of the new heart allocation policy on patients with restrictive, hypertrophic, or congenital cardiomyopathies. PLOS ONE 2021, 16: e0247789. PMID: 33651802, PMCID: PMC7924739, DOI: 10.1371/journal.pone.0247789.Peer-Reviewed Original ResearchMeSH KeywordsAdultCardiomyopathy, HypertrophicCardiomyopathy, RestrictiveFemaleHeart Defects, CongenitalHeart TransplantationHumansMaleMiddle AgedPolicyRegistriesTissue and Organ ProcurementUnited StatesConceptsCongenital heart diseaseAllocation system changeHeart allocation systemNew heart allocation policyNew heart allocation systemTransplantation of patientsOrgan Sharing databasePost-transplantation outcomesPost-transplant survivalTime of transplantationMechanical circulatory supportRate of transplantationNumber of patientsHeart allocation policyNew allocation systemStatus 1ACardiac transplantAdult patientsSharing databaseWaitlist survivalCirculatory supportClinical benefitCongenital cardiomyopathyUnited NetworkCHD patientsCurrent status: meeting the regulatory goals of your liver transplant program.
Batra RK, Mulligan DC. Current status: meeting the regulatory goals of your liver transplant program. Current Opinion In Organ Transplantation 2021, 26: 146-151. PMID: 33650996, DOI: 10.1097/mot.0000000000000869.Peer-Reviewed Original ResearchAgedCenters for Medicare and Medicaid Services, U.S.GoalsHumansLiver TransplantationMedicareTissue and Organ ProcurementUnited States
2020
Deceased donors: Defining drug‐related deaths
Cmunt K, Danovitch G, Delmonico F, Fynn‐Thompson F, Glazier A, Grandas J, Gunderson S, Jendrisak M, Johnson HK, Kulkarni S, Lipkowitz G, Meyer K, Mulligan D, Nathan H, Mone T, Moritz M, O'Connor K, Payne W, Souter M, Wood RP. Deceased donors: Defining drug‐related deaths. Clinical Transplantation 2020, 34: e13800. PMID: 32077534, DOI: 10.1111/ctr.13800.Peer-Reviewed Original Research
2019
Frequency of whole-organ in lieu of split-liver transplantation over the last decade: Children experienced increased wait time and death
Valentino PL, Emre S, Geliang G, Li L, Deng Y, Mulligan D, Rodriguez-Davalos M. Frequency of whole-organ in lieu of split-liver transplantation over the last decade: Children experienced increased wait time and death. American Journal Of Transplantation 2019, 19: 3114-3123. PMID: 31152483, DOI: 10.1111/ajt.15481.Peer-Reviewed Original ResearchConceptsAdult recipientsTransplantation Network/United NetworkNumber of allograftsOrgan Sharing dataSplit-liver transplantationCareful patient selectionDeceased donor liversNumber of LTLT graftSLT recipientsUnderwent LTWLT recipientsPediatric candidatesPatient selectionDonor liversOrgan utilizationUnited NetworkOrgan shortageOrgan procurementSmall childrenRecipientsTransplantation
2017
Predictors of Waitlist Mortality in Portopulmonary Hypertension
DuBrock HM, Goldberg DS, Sussman NL, Bartolome SD, Kadry Z, Salgia RJ, Mulligan DC, Kremers WK, Kawut SM, Krowka MJ, Channick RN. Predictors of Waitlist Mortality in Portopulmonary Hypertension. Transplantation 2017, 101: 1609-1615. PMID: 28207639, PMCID: PMC5481480, DOI: 10.1097/tp.0000000000001666.Peer-Reviewed Original ResearchMeSH KeywordsArterial PressureCause of DeathChi-Square DistributionDatabases, FactualDecision Support TechniquesFemaleHumansHypertension, PortalHypertension, PulmonaryKaplan-Meier EstimateLiver DiseasesLiver TransplantationMaleMiddle AgedMultivariate AnalysisPortal PressurePredictive Value of TestsProportional Hazards ModelsPulmonary ArteryPulmonary CirculationRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTissue and Organ ProcurementTreatment OutcomeVascular ResistanceWaiting ListsConceptsPortopulmonary hypertensionWaitlist mortalityMELD exceptionsLiver diseaseException scoreEnd-Stage Liver Disease (MELD) exception pointsSignificant predictorsCox proportional hazards modelMELD exception scoreWaitlist mortality riskRetrospective cohort studyPulmonary arterial pressureTransplantation Network databaseSignificant univariate predictorsOnly significant univariate predictorsProportional hazards modelMELD scorePosttransplant mortalityPulmonary hypertensionCohort studyArterial pressureUnivariate predictorsC-statisticMortality riskHazards modelInequity in organ allocation for patients awaiting liver transplantation: Rationale for uncapping the model for end-stage liver disease
Nadim MK, DiNorcia J, Ji L, Groshen S, Levitsky J, Sung RS, Kim WR, Andreoni K, Mulligan D, Genyk YS. Inequity in organ allocation for patients awaiting liver transplantation: Rationale for uncapping the model for end-stage liver disease. Journal Of Hepatology 2017, 67: 517-525. PMID: 28483678, PMCID: PMC7735955, DOI: 10.1016/j.jhep.2017.04.022.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overEnd Stage Liver DiseaseFemaleHumansLiver TransplantationMaleMiddle AgedTissue and Organ ProcurementWaiting ListsYoung AdultConceptsEnd-stage liver diseaseLiver transplantMELD scoreLiver diseaseSick patientsLiver transplantationOrgan allocationEquitable organ distributionGreater MELD scoresPost-transplant outcomesOrgan Sharing dataPost-transplant survivalUnderwent liver transplantObjective scoring systemWaitlist registrationWaitlist mortalityHazard ratioSurvival benefitWaitlist candidatesUnited NetworkPatientsTransplantScoring systemMELDOrgan distributionLiver allocation and distribution
Deshpande R, Hirose R, Mulligan D. Liver allocation and distribution. Current Opinion In Organ Transplantation 2017, 22: 162-168. PMID: 28212159, DOI: 10.1097/mot.0000000000000397.Peer-Reviewed Original ResearchConceptsTransplant CommitteeTransplant centersEnd-Stage Liver Disease (MELD) pointsLiver allograft allocationDeceased donor liversLife-saving organsLiver allocation policyAllograft allocationLiver transplantLiver transplantationLiver diseaseDonor liversUnited NetworkDonor organsLiver distributionAdvanced stageLiver allocationOrgan distributionPatient accessTransplantationGeographic disparitiesLiverDisease pointHealthcare systemPatients
2016
Predicting Outcomes on the Liver Transplant Waiting List in the United States
Hart A, Schladt DP, Zeglin J, Pyke J, Kim WR, Lake JR, Roberts JP, Hirose R, Mulligan DC, Kasiske BL, Snyder JJ, Israni AK. Predicting Outcomes on the Liver Transplant Waiting List in the United States. Transplantation 2016, 100: 2153-2159. PMID: 27490411, PMCID: PMC5369025, DOI: 10.1097/tp.0000000000001384.Peer-Reviewed Original ResearchMeSH KeywordsAdultEnd Stage Liver DiseaseHumansLiver TransplantationSeverity of Illness IndexTissue and Organ ProcurementTissue DonorsUnited StatesWaiting ListsConceptsDonation service areaLiver transplantWaiting listEnd-stage liver disease (MELD) scoreLiver transplant waiting listTransplant Recipients databaseLiver Disease scoreMELD exception pointsTransplant waiting listAvailability of organsTransplant probabilityRecipients databasePatient characteristicsScientific RegistryTransplant programsUS adultsDisease scorePredicting OutcomeException pointsTransplantBlood typeOutcomesOngoing disparitiesCorresponding percentilesOnline calculatorResolving Misconceptions About Liver Allocation and Redistricting Methodology
Gentry SE, Hirose R, Mulligan D. Resolving Misconceptions About Liver Allocation and Redistricting Methodology. JAMA Surgery 2016, 151: 991-992. PMID: 27333440, DOI: 10.1001/jamasurg.2016.1315.Peer-Reviewed Original ResearchAttitudes toward organ donation among waitlisted transplant patients: results of a cross‐sectional survey
Merola J, Pei K, Rodriguez‐Davalos M, Gan G, Deng Y, Mulligan DC, Davis KA. Attitudes toward organ donation among waitlisted transplant patients: results of a cross‐sectional survey. Clinical Transplantation 2016, 30: 1449-1456. PMID: 27582432, PMCID: PMC5093046, DOI: 10.1111/ctr.12839.Peer-Reviewed Original ResearchConceptsCross-sectional surveyOrgan donationWaitlisted candidatesMinority of patientsDonor registration ratesDonation eligibilityTransplant patientsWaitlisted patientsPatients' willingnessGeneral populationOrgan donorsOrgan shortageMedical treatmentPatientsOrgan allocationDonation ratesTransplantationRegistration ratesDonationMajor barrierPopulationDonorsWaitlistPhysiciansDemographicsThe Long‐Term Follow‐up and Support for Living Organ Donors: A Center‐Based Initiative Founded on Developing a Community of Living Donors
Kulkarni S, Thiessen C, Formica RN, Schilsky M, Mulligan D, D'Aquila R. The Long‐Term Follow‐up and Support for Living Organ Donors: A Center‐Based Initiative Founded on Developing a Community of Living Donors. American Journal Of Transplantation 2016, 16: 3385-3391. PMID: 27500361, DOI: 10.1111/ajt.14005.Peer-Reviewed Original ResearchMeSH KeywordsContinuity of Patient CareDelivery of Health CareHumansLiving DonorsOrgan TransplantationPrognosisQuality of LifeTissue and Organ ProcurementThe impact of broader regional sharing of livers: 2‐year results of “Share 35”
Edwards EB, Harper AM, Hirose R, Mulligan DC. The impact of broader regional sharing of livers: 2‐year results of “Share 35”. Liver Transplantation 2016, 22: 399-409. PMID: 26890858, DOI: 10.1002/lt.24418.Peer-Reviewed Original ResearchMeSH KeywordsChildCold IschemiaFemaleGraft SurvivalHealth Impact AssessmentHumansLiver FailureLiver TransplantationMaleMiddle AgedTissue and Organ ProcurementTissue DonorsTreatment OutcomeWaiting ListsConceptsWaiting list mortalityLiver transplantLiver diseaseEnd-stage liver disease candidatesEnd-stage liver diseasePosttransplant survival outcomesChronic liver diseaseCold ischemia timeShare 35 policyRegional sharingBroader regional sharingPost-policy periodPosttransplant graftUrgent groupIschemia timePatient survivalSurvival outcomesMedian MELDMortality rateSickest candidatesOrgan procurementTransplantation NetworkTransplantAge groupsUrgent patientsSimultaneous Liver–Kidney Allocation Policy: A Proposal to Optimize Appropriate Utilization of Scarce Resources
Formica R, Aeder M, Boyle G, Kucheryavaya A, Stewart D, Hirose R, Mulligan D. Simultaneous Liver–Kidney Allocation Policy: A Proposal to Optimize Appropriate Utilization of Scarce Resources. American Journal Of Transplantation 2016, 16: 758-766. PMID: 26603142, DOI: 10.1111/ajt.13631.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedDonor SelectionFemaleHealth PolicyHumansKidney TransplantationLiver TransplantationMaleMiddle AgedPrognosisTissue and Organ ProcurementWaiting ListsConceptsMayo End-Stage Liver Disease (MELD) scoreEnd-stage liver disease (MELD) scoreSimultaneous liver-kidney transplantKidney Donor Profile IndexConcurrent kidney transplantsLiver-kidney transplantLiver Disease scoreMedical Eligibility CriteriaLiver allocation policyOPTN Final RulePediatric recipientsKidney transplantRenal functionRenal insufficiencyUnited NetworkLiver candidatesTransplant communityDisease scoreOrgan donorsEligibility criteriaOrgan procurementTransplantation NetworkFinal ruleKidney allocationYoung adults
2014
Written informed consent for living liver donor evaluation: Compliance with centers for medicare and medicaid services and organ procurement and transplantation network guidelines and alibi offers
Thiessen C, Kim YA, Yoo PS, Rodriguez‐Davalos M, Mulligan D, Kulkarni S. Written informed consent for living liver donor evaluation: Compliance with centers for medicare and medicaid services and organ procurement and transplantation network guidelines and alibi offers. Liver Transplantation 2014, 20: 416-424. PMID: 24415564, DOI: 10.1002/lt.23822.Peer-Reviewed Original ResearchMeSH KeywordsCenters for Medicare and Medicaid Services, U.S.Guidelines as TopicHumansInformed ConsentInternetLiver TransplantationLiving DonorsMedicaidMedicareTissue and Organ ProcurementUnited States
2012
A Consolidated Biovigilance System for Blood, Tissue and Organs: One Size Does Not Fit All
Pruett TL, Blumberg EA, Cohen DJ, Crippin JS, Freeman RB, Hanto DW, Mulligan DC, Green MD. A Consolidated Biovigilance System for Blood, Tissue and Organs: One Size Does Not Fit All. American Journal Of Transplantation 2012, 12: 1099-1101. PMID: 22487495, DOI: 10.1111/j.1600-6143.2011.03907.x.Peer-Reviewed Original ResearchMeSH KeywordsBlood TransfusionHealth PolicyHumansOrgan TransplantationTissue and Organ ProcurementTissue TransplantationConceptsOrgan transplant recipientsLimited organ availabilityPublic health servicesTransplant recipientsDonor testingOrgan availabilityWaiting listClinical practiceHealth servicesFormal recommendationsTransfer of organsDisease transmissionBloodOrgansOverall benefitTissueTransplantationSupport effortsRecipients
2009
ASTS Recommended Practice Guidelines for Controlled Donation after Cardiac Death Organ Procurement and Transplantation
Reich DJ, Mulligan DC, Abt PL, Pruett TL, Abecassis MM, D’Alessandro A, Pomfret EA, Freeman RB, Markmann JF, Hanto DW, Matas AJ, Roberts JP, Merion RM, Klintmalm GB, Committee T. ASTS Recommended Practice Guidelines for Controlled Donation after Cardiac Death Organ Procurement and Transplantation. American Journal Of Transplantation 2009, 9: 2004-2011. PMID: 19624569, DOI: 10.1111/j.1600-6143.2009.02739.x.Peer-Reviewed Original ResearchConceptsOrgan donationFavorable posttransplant outcomesOrgan acceptance criteriaOrgan procurement organizationsBrain death criteriaBiliary issuesDCD kidneysPancreas transplantationVentilatory supportPosttransplant outcomesCardiac deathTransplant centersIschemia timeDCD protocolsHopeless prognosisMachine perfusionBrain deathTransplant surgeonsOperative techniqueOrgan transplantationPractice guidelinesBest practice guidelinesOrgan procurementDonor characteristicsTransplantation
2007
Diffuse Parenchymal Urine Leak After Kidney Transplantation Following Degloving Injury During Donor Nephrectomy
Mekeel KL, Mazur MJ, Reddy KS, Mulligan DC, Heilman RL, Chakkera HA, Andrews PE, Moss AA. Diffuse Parenchymal Urine Leak After Kidney Transplantation Following Degloving Injury During Donor Nephrectomy. American Journal Of Transplantation 2007, 7: 2039-2041. PMID: 17578504, DOI: 10.1111/j.1600-6143.2007.01870.x.Peer-Reviewed Original ResearchMeSH KeywordsFemaleFollow-Up StudiesHumansIntraoperative ComplicationsKidneyKidney TransplantationLaparoscopyMiddle AgedNephrectomyReoperationTissue and Organ ProcurementTissue DonorsTreatment FailureConceptsDonor nephrectomyUrine leakRecipient graft functionGood renal functionLaparoscopic donor nephrectomyComplete deglovingGraft functionKidney transplantationPostoperative courseRenal functionPeritoneal windowLarge urinomaGlue treatmentKidneyUnconcentrated urineKidney surfaceNephrectomyLeakUrinomaPatientsTransplantationDeglovingInjuryTraumaUrine