2011
P1-06-24: Nuclear Localization of Stat5a Predicts Response to Antiestrogen Therapy and Prognosis of Clinical Breast Cancer Outcome.
Peck A, Witkiewicz A, Liu C, Klimowicz A, Stringer G, Pequignot E, Freydin B, Yang N, Tran T, Rosenberg A, Hooke J, Kovatich A, Shriver C, Rimm D, Magliocco A, Hyslop T, Rui H. P1-06-24: Nuclear Localization of Stat5a Predicts Response to Antiestrogen Therapy and Prognosis of Clinical Breast Cancer Outcome. Cancer Research 2011, 71: p1-06-24-p1-06-24. DOI: 10.1158/0008-5472.sabcs11-p1-06-24.Peer-Reviewed Original ResearchCancer-specific survivalBreast cancer outcomesBreast cancer patientsAntiestrogen therapyClinical featuresCancer outcomesCancer patientsBreast cancerStandard immunohistochemistryNode-negative breast cancer patientsPathologist scoringPoor breast cancer outcomesBreast cancer-specific survivalQuantitative immunofluorescencePoor breast cancer prognosisInvasive breast cancer tissuesHormone receptor statusPredictors of responseFavorable prognostic markerBreast cancer prognosisBreast cancer tissuesNormal mammary developmentUseful clinical toolWhole tissue sectionsAntiestrogen response
2006
Quantitative In situ Analysis of β-Catenin Expression in Breast Cancer Shows Decreased Expression Is Associated with Poor Outcome
Dolled-Filhart M, McCabe A, Giltnane J, Cregger M, Camp RL, Rimm DL. Quantitative In situ Analysis of β-Catenin Expression in Breast Cancer Shows Decreased Expression Is Associated with Poor Outcome. Cancer Research 2006, 66: 5487-5494. PMID: 16707478, DOI: 10.1158/0008-5472.can-06-0100.Peer-Reviewed Original ResearchConceptsProgesterone receptorEstrogen receptorPrognostic valueBreast cancerKi-67X-tile softwareProportional hazards modelBreast cancer prognosisBreast cancer showBreast cancer tumorsΒ-catenin expressionYale Pathology archivesHazard ratioNode statusPoor outcomeTumor sizePrognostic markerWorse outcomesImmunohistochemical studyNuclear gradeCase cohortLow-level expressionPathology archivesTissue microarrayBeta-catenin expression