2013
Tissue microarrays: leaping the gap between research and clinical adoption
Gustavson MD, Rimm DL, Dolled-Filhart M. Tissue microarrays: leaping the gap between research and clinical adoption. Personalized Medicine 2013, 10: 441-451. PMID: 29758838, DOI: 10.2217/pme.13.42.Peer-Reviewed Original ResearchTissue microarrayClinical laboratory settingUse of TMAsRoutine diagnostic purposesAdvanced imagingClinical settingPatient samplesDiagnostic useTissue assessmentTranslational research settingsExpression assessmentClinical research applicationsBiomarker analysisDiagnostic assaysDiagnostic purposesResearch settingsClinical adoption
2011
P1-07-03: Preanalytical Variables Affect Protein Expression in Formalin Fixed Paraffin Embedded Tissue – Assessment of Intrinsic Controls To Define Tissue Quality for Immunohistochemical Analysis.
Neumeister V, Lostritto K, Siddiqui S, Anagnostou V, Vassilakopoulou M, Zarrella E, Molinaro A, Hicks D, Rimm D. P1-07-03: Preanalytical Variables Affect Protein Expression in Formalin Fixed Paraffin Embedded Tissue – Assessment of Intrinsic Controls To Define Tissue Quality for Immunohistochemical Analysis. Cancer Research 2011, 71: p1-07-03-p1-07-03. DOI: 10.1158/0008-5472.sabcs11-p1-07-03.Peer-Reviewed Original ResearchIschemic timeProtein expressionBreast cancerFormalin fixationDifferent breast cancer cohortsTumor tissuePairs of biopsiesTumor heterogeneityBreast cancer cohortBreast cancer biopsiesBreast cancer specimenPre-analytical variablesHistone 4ER alphaCancer cohortImmunohistochemical analysisCancer biopsiesSecond cohortAQUA scoreCancer specimenClinical settingQuantitative immunofluorescenceResectionCancer ResBiopsy
2009
Evaluation of the false-negative rate of standardized and quantitative measurement of estrogen receptor (ER) in tissue using AQUA technology
Gustavson M, Welsh A, Jones C, Mayotte J, Tu J, Hopkins J, Rimm D, Christiansen J. Evaluation of the false-negative rate of standardized and quantitative measurement of estrogen receptor (ER) in tissue using AQUA technology. Journal Of Clinical Oncology 2009, 27: 567-567. DOI: 10.1200/jco.2009.27.15_suppl.567.Peer-Reviewed Original ResearchER protein expressionEstrogen receptorBreast cancer samplesPg/AQUA analysisFalse negative rateAQUA technologyCancer samplesAllred scoring systemProtein expressionChange of diagnosisEstrogen receptor testingReproducible diagnostic testFalse-negative testsHigh false-negative rateReceptor testingER testingAllred scoreLarge cohortNegative testAQUA scoreScoring systemMisclassified casesClinical settingConcordance rate