2020
Quantitative analysis of CMTM6 expression in tumor microenvironment in metastatic melanoma and association with outcome on immunotherapy
Martinez-Morilla S, Zugazagoitia J, Wong PF, Kluger HM, Rimm DL. Quantitative analysis of CMTM6 expression in tumor microenvironment in metastatic melanoma and association with outcome on immunotherapy. OncoImmunology 2020, 10: 1864909. PMID: 33457084, PMCID: PMC7781756, DOI: 10.1080/2162402x.2020.1864909.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsPD-L1CMTM6 expressionControl patientsLonger survivalTissue microarrayQuantitative immunofluorescenceEffectiveness of immunotherapyMetastatic melanoma patientsDeath ligand 1Like MARVEL transmembrane domainCancer Genome Atlas (TCGA) databaseExpression of CMTM6MARVEL transmembrane domainExpression of mRNAChemokine-like factorICI treatmentCheckpoint inhibitorsPretreatment biopsiesCD68 markersImmune compartmentMultivariable analysisMelanoma patientsImmune-related proteinsPredictive factors
2004
Increased Tissue Microarray Matrix Metalloproteinase Expression Favors Proteolysis in Thoracic Aortic Aneurysms and Dissections
Koullias GJ, Ravichandran P, Korkolis DP, Rimm DL, Elefteriades JA. Increased Tissue Microarray Matrix Metalloproteinase Expression Favors Proteolysis in Thoracic Aortic Aneurysms and Dissections. The Annals Of Thoracic Surgery 2004, 78: 2106-2110. PMID: 15561045, DOI: 10.1016/j.athoracsur.2004.05.088.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntibodies, MonoclonalAorta, ThoracicAortic Aneurysm, ThoracicAortic DissectionFemaleHumansMaleMatrix Metalloproteinase 1Matrix Metalloproteinase 2Matrix Metalloproteinase 9Matrix MetalloproteinasesTissue Array AnalysisTissue Inhibitor of Metalloproteinase-1Tissue Inhibitor of Metalloproteinase-2ConceptsAortic dissection patientsHigher MMP-2Thoracic aortic aneurysmAortic aneurysmMMP-9MMP-2Dissection patientsThoracic aneurysmMMP-1Matrix metalloproteinasesControl aortic specimensAortic aneurysm patientsTIMP-1 ratioEntire patient groupImportant pathophysiologic roleMMP-9 expressionMatrix metalloproteinase expressionAreas of diseaseControl patientsAortic dissectionControl specimensPathophysiologic mechanismsAortic diseasePatient groupAneurysm patients