2017
Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors
Hendry S, Salgado R, Gevaert T, Russell PA, John T, Thapa B, Christie M, van de Vijver K, Estrada MV, Gonzalez-Ericsson PI, Sanders M, Solomon B, Solinas C, Van den Eynden GGGM, Allory Y, Preusser M, Hainfellner J, Pruneri G, Vingiani A, Demaria S, Symmans F, Nuciforo P, Comerma L, Thompson EA, Lakhani S, Kim SR, Schnitt S, Colpaert C, Sotiriou C, Scherer SJ, Ignatiadis M, Badve S, Pierce RH, Viale G, Sirtaine N, Penault-Llorca F, Sugie T, Fineberg S, Paik S, Srinivasan A, Richardson A, Wang Y, Chmielik E, Brock J, Johnson DB, Balko J, Wienert S, Bossuyt V, Michiels S, Ternes N, Burchardi N, Luen SJ, Savas P, Klauschen F, Watson PH, Nelson BH, Criscitiello C, O’Toole S, Larsimont D, de Wind R, Curigliano G, André F, Lacroix-Triki M, van de Vijver M, Rojo F, Floris G, Bedri S, Sparano J, Rimm D, Nielsen T, Kos Z, Hewitt S, Singh B, Farshid G, Loibl S, Allison KH, Tung N, Adams S, Willard-Gallo K, Horlings HM, Gandhi L, Moreira A, Hirsch F, Dieci MV, Urbanowicz M, Brcic I, Korski K, Gaire F, Koeppen H, Lo A, Giltnane J, Rebelatto MC, Steele KE, Zha J, Emancipator K, Juco JW, Denkert C, Reis-Filho J, Loi S, Fox SB. Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors. Advances In Anatomic Pathology 2017, 24: 311-335. PMID: 28777143, PMCID: PMC5638696, DOI: 10.1097/pap.0000000000000161.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorBiopsyBrain NeoplasmsCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellEndometrial NeoplasmsFemaleGastrointestinal NeoplasmsHead and Neck NeoplasmsHumansImmunohistochemistryLung NeoplasmsLymphocytes, Tumor-InfiltratingMelanomaMesotheliomaOvarian NeoplasmsPathologyPhenotypePredictive Value of TestsSkin NeoplasmsSquamous Cell Carcinoma of Head and NeckUrogenital NeoplasmsConceptsTumor-infiltrating lymphocytesDifferent tumor typesSolid tumorsTumor typesTIL assessmentImmune responsePrimary brain tumorsCommon solid tumorsInvasive breast carcinomaRoutine clinical biomarkersWorking Group guidelinesPrognostic implicationsBreast carcinomaGroup guidelinesGynecologic systemGastrointestinal tractSimple biomarkerBrain tumorsGenitourinary systemPredictive valueClinical biomarkersStandardized methodologyTumorsAvailable evidenceImmunotherapyAssessing Tumor-infiltrating Lymphocytes in Solid Tumors
Hendry S, Salgado R, Gevaert T, Russell PA, John T, Thapa B, Christie M, van de Vijver K, Estrada MV, Gonzalez-Ericsson PI, Sanders M, Solomon B, Solinas C, Van den Eynden GGGM, Allory Y, Preusser M, Hainfellner J, Pruneri G, Vingiani A, Demaria S, Symmans F, Nuciforo P, Comerma L, Thompson EA, Lakhani S, Kim SR, Schnitt S, Colpaert C, Sotiriou C, Scherer SJ, Ignatiadis M, Badve S, Pierce RH, Viale G, Sirtaine N, Penault-Llorca F, Sugie T, Fineberg S, Paik S, Srinivasan A, Richardson A, Wang Y, Chmielik E, Brock J, Johnson DB, Balko J, Wienert S, Bossuyt V, Michiels S, Ternes N, Burchardi N, Luen SJ, Savas P, Klauschen F, Watson PH, Nelson BH, Criscitiello C, O’Toole S, Larsimont D, de Wind R, Curigliano G, André F, Lacroix-Triki M, van de Vijver M, Rojo F, Floris G, Bedri S, Sparano J, Rimm D, Nielsen T, Kos Z, Hewitt S, Singh B, Farshid G, Loibl S, Allison KH, Tung N, Adams S, Willard-Gallo K, Horlings HM, Gandhi L, Moreira A, Hirsch F, Dieci MV, Urbanowicz M, Brcic I, Korski K, Gaire F, Koeppen H, Lo A, Giltnane J, Rebelatto MC, Steele KE, Zha J, Emancipator K, Juco JW, Denkert C, Reis-Filho J, Loi S, Fox SB. Assessing Tumor-infiltrating Lymphocytes in Solid Tumors. Advances In Anatomic Pathology 2017, 24: 235-251. PMID: 28777142, PMCID: PMC5564448, DOI: 10.1097/pap.0000000000000162.Peer-Reviewed Original ResearchConceptsTumor-infiltrating lymphocytesTIL assessmentInvasive breast carcinomaSolid tumor typesBreast carcinomaSolid tumorsTumor typesDifferent solid tumor typesForm of immunotherapyImmune checkpoint inhibitorsEra of immunotherapyImportant prognostic informationRoutine clinical biomarkersHost immune responseWorking Group guidelinesDiverse solid tumor typesCheckpoint inhibitorsMetastatic settingPrognostic informationGroup guidelinesImmune responseEosin sectionsHistopathologic specimensClinical validityPredictive significance
2007
Hormonal Markers in Breast Cancer: Coexpression, Relationship with Pathologic Characteristics, and Risk Factor Associations in a Population-Based Study
Yang XR, Pfeiffer RM, Garcia-Closas M, Rimm DL, Lissowska J, Brinton LA, Peplonska B, Hewitt SM, Cartun RW, Mandich D, Sasano H, Evans DB, Sutter TR, Sherman ME. Hormonal Markers in Breast Cancer: Coexpression, Relationship with Pathologic Characteristics, and Risk Factor Associations in a Population-Based Study. Cancer Research 2007, 67: 10608-10617. PMID: 17968031, DOI: 10.1158/0008-5472.can-07-2142.Peer-Reviewed Original ResearchConceptsCurrent body mass indexBody mass indexPremenopausal womenPathologic characteristicsMass indexHormonal markersMolecular subtypesHigher current body mass indexPopulation-based case-control studyProliferation factorsEpidemiologic risk factorsRisk factor associationsHigh tumor gradeCase-control studyInvasive breast carcinomaBreast cancer tissuesER betaRisk factorsTumor gradeBreast carcinomaCoexpression patternsBreast cancerHigher scoresEarly menarcheCancer tissues
2006
Construction and Validation of Tissue Microarrays of Ductal Carcinoma In Situ and Terminal Duct Lobular Units Associated With Invasive Breast Carcinoma
Yang XR, Charette LA, Garcia-Closas M, Lissowska J, Paal E, Sidawy M, Hewitt SM, Rimm DL, Sherman ME. Construction and Validation of Tissue Microarrays of Ductal Carcinoma In Situ and Terminal Duct Lobular Units Associated With Invasive Breast Carcinoma. Applied Immunohistochemistry & Molecular Morphology 2006, 15: 157-161. PMID: 16932071, DOI: 10.1097/01.pdm.0000213453.45398.e0.Peer-Reviewed Original ResearchConceptsTerminal duct lobular unitsTissue microarrayEstrogen receptorDuctal carcinomaProgesterone receptorBreast cancerLobular unitsLarge case-control studyPR expression levelsCase-control studyInvasive breast carcinomaPercentage of tubulesInvasive carcinomaEpithelial lesionsBreast carcinomaImmunohistochemical characterizationImmunohistochemical stainingPeritumoral tissuesPositive stainingScoring systemCarcinomaCategorical scoring systemBreast tissueMethodologic studyExpression levels
2000
Validation of Tissue Microarray Technology in Breast Carcinoma
Camp R, Charette L, Rimm D. Validation of Tissue Microarray Technology in Breast Carcinoma. Laboratory Investigation 2000, 80: 1943-1949. PMID: 11140706, DOI: 10.1038/labinvest.3780204.Peer-Reviewed Original ResearchConceptsWhole tissue sectionsInvasive breast carcinomaBreast carcinomaTissue microarray technologyLarge-scale retrospective cohort studyTissue sectionsArchival tissueRetrospective cohort studyHER2/neu oncogeneTissue microarray techniqueCohort studyBreast cancer microarrayProgesterone receptorArchival cohortEstrogen receptorAmount of tissueCommon antigenNeu oncogeneEntire tumorCarcinomaProtein expressionProtein expression patternsArchival formalinTissueReceptors