2019
Prediction of distant melanoma recurrence from primary tumor digital H&E images using deep learning.
Robinson E, Kulkarni P, Pradhan J, Gartrell R, Yang C, Rizk E, Acs B, Rohr B, Phelps R, Ferringer T, Horst B, Rimm D, Wang J, Saenger Y. Prediction of distant melanoma recurrence from primary tumor digital H&E images using deep learning. Journal Of Clinical Oncology 2019, 37: 9577-9577. DOI: 10.1200/jco.2019.37.15_suppl.9577.Peer-Reviewed Original ResearchDeep neural net architectureOpen source softwareRecurrent neural networkNeural net architectureDigital pathology toolsDeep learningSource softwareNet architectureFeature informationNeural networkNetwork parametersTIFF filesAdjuvant immunotherapyMelanoma recurrenceCohort 2Cohort 1Cell classificationStage IMultivariable Cox proportional hazards modelsDNNCox proportional hazards modelColumbia University Medical CenterNuclear segmentationEvidence of diseaseIndependent prognostic factor
2014
Prognostic Biomarkers in Phase II Trial of Cetuximab-Containing Induction and Chemoradiation in Resectable HNSCC: Eastern Cooperative Oncology Group E2303
Psyrri A, Lee JW, Pectasides E, Vassilakopoulou M, Kosmidis EK, Burtness BA, Rimm DL, Wanebo HJ, Forastiere AA. Prognostic Biomarkers in Phase II Trial of Cetuximab-Containing Induction and Chemoradiation in Resectable HNSCC: Eastern Cooperative Oncology Group E2303. Clinical Cancer Research 2014, 20: 3023-3032. PMID: 24700741, PMCID: PMC4049169, DOI: 10.1158/1078-0432.ccr-14-0113.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntibodies, Monoclonal, HumanizedAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorCarboplatinCarcinoma, Squamous CellCetuximabChemoradiotherapyDisease-Free SurvivalDrug Resistance, NeoplasmFemaleFluorescent Antibody TechniqueHead and Neck NeoplasmsHumansInduction ChemotherapyKaplan-Meier EstimateMaleMiddle AgedMitogen-Activated Protein Kinase KinasesPaclitaxelPhosphatidylinositol 3-KinasesPrognosisProportional Hazards ModelsProto-Oncogene Proteins c-aktRas ProteinsSignal TransductionSquamous Cell Carcinoma of Head and NeckTissue Array AnalysisConceptsProgression-free survivalEvent-free survivalPhase II trialOverall survivalII trialTissue microarrayStage III/IV headMultivariable Cox proportional hazards modelsMultivariable Cox regression analysisNeck squamous cell cancerRAS/MAPK/ERKCox proportional hazards modelInsulin-like growth factor 1 receptorLarge prospective studiesCox regression analysisInferior overall survivalKaplan-Meier methodSquamous cell cancerLog-rank testGrowth factor 1 receptorProportional hazards modelPI3K/Akt pathwayFactor 1 receptorPI3K/AktEGF receptor