2022
Development of an immunohistochemical assay for Siglec-15
Shafi S, Aung TN, Robbins C, Zugazagoitia J, Vathiotis I, Gavrielatou N, Yaghoobi V, Fernandez A, Niu S, Liu LN, Cusumano ZT, Leelatian N, Cole K, Wang H, Homer R, Herbst RS, Langermann S, Rimm DL. Development of an immunohistochemical assay for Siglec-15. Laboratory Investigation 2022, 102: 771-778. PMID: 35459795, PMCID: PMC9253057, DOI: 10.1038/s41374-022-00785-9.Peer-Reviewed Original ResearchConceptsSiglec-15IHC assaysPD-L1PD-1/PD-L1 inhibitionPD-L1 blockadePD-L1 inhibitionHigh expressionFuture clinical trialsImmunoglobulin-type lectinsSiglec-15 expressionCompanion diagnostic assayPromising new targetTumor histologyImmunotherapeutic targetLung cancerImmune cellsClinical trialsNovel recombinant antibodiesCancer histologyImmunohistochemical assaysMyeloid cellsTumor typesScoring systemNew targetsHigh concordance
2005
Quantitative insitu cancer proteomics: molecular pathology comes of age with automated tissue microarray analysis
Dolled-Filhart MP, Rimm DL, Stroobant P. Quantitative insitu cancer proteomics: molecular pathology comes of age with automated tissue microarray analysis. Personalized Medicine 2005, 2: 291-300. PMID: 29788575, DOI: 10.2217/17410541.2.4.291.Peer-Reviewed Original ResearchProtein expression analysisExpression analysisProtein expressionPotential future therapeutic developmentsHigh-throughput methodAutomated Quantitative AnalysisMicroarray analysisTarget discoverySitu protein expressionTissue microarray analysisFluorescence microscopyFuture therapeutic developmentMicroarrayTissue microarrayNew targetsDynamic rangeDiscovery toolMolecular pathologyTherapeutic developmentUnparalleled opportunityUnique roleMicroscope slidesTumor samplesExpressionNovel prognostic marker