2012
Stathmin expression and its relationship to microtubule‐associated protein tau and outcome in breast cancer
Baquero MT, Hanna JA, Neumeister V, Cheng H, Molinaro AM, Harris LN, Rimm DL. Stathmin expression and its relationship to microtubule‐associated protein tau and outcome in breast cancer. Cancer 2012, 118: 4660-4669. PMID: 22359235, PMCID: PMC3391341, DOI: 10.1002/cncr.27453.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnalysis of VarianceBiomarkers, TumorBlotting, WesternBreastBreast NeoplasmsCell Line, TumorCohort StudiesFemaleFluorescent Antibody TechniqueGene Expression Regulation, NeoplasticHumansImmunohistochemistryKaplan-Meier EstimateLymphatic MetastasisMiddle AgedNeoplasm GradingNeoplasm StagingOdds RatioPredictive Value of TestsPrognosisProportional Hazards ModelsRisk AssessmentRisk FactorsRNA, Small InterferingStathminTau ProteinsTissue Array AnalysisTreatment OutcomeConceptsHigh stathmin expressionDisease-free survivalMAP-tauOverall survivalStathmin expressionBreast cancerHuman epidermal growth factor receptor 2 (HER2) expressionEpidermal growth factor receptor 2 expressionMultivariate analysisCox proportional hazards modelWorse overall survivalReceptor 2 expressionTissue microarray formatMicrotubule-associated protein tauProportional hazards modelBreast cancer cohortIndependent predictorsMenopausal statusNodal statusBetter prognosisPrognostic valueTumor sizePathological characteristicsProgesterone receptorNuclear grade
2010
High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology
Anagnostou VK, Lowery FJ, Zolota V, Tzelepi V, Gopinath A, Liceaga C, Panagopoulos N, Frangia K, Tanoue L, Boffa D, Gettinger S, Detterbeck F, Homer RJ, Dougenis D, Rimm DL, Syrigos KN. High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology. BMC Cancer 2010, 10: 186. PMID: 20459695, PMCID: PMC2875218, DOI: 10.1186/1471-2407-10-186.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAgedBiomarkers, TumorCarcinoma, Large CellCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellCell DifferentiationCohort StudiesConnecticutFemaleGreeceHumansKaplan-Meier EstimateLung NeoplasmsMaleMiddle AgedNeoplasm StagingPredictive Value of TestsProportional Hazards ModelsProto-Oncogene Proteins c-bcl-2Reproducibility of ResultsRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUp-RegulationConceptsNon-small cell lung cancer patientsCell lung cancer patientsNon-squamous tumorsLung cancer patientsBcl-2 expressionNSCLC patientsCancer patientsBcl-2Favorable outcomeIndependent cohortSmall cell lung cancer patientsIndependent lower riskNon-squamous histologySubgroup of patientsHigh expressersSquamous cell carcinomaHigh Bcl-2 expressionBcl-2 protein levelsSquamous histologyMedian survivalPrognostic factorsValidation cohortCell carcinomaPathological characteristicsPrognostic stratification
2009
Association of expression of bcl-2 with outcome in non-small cell lung cancer
Anagnostou V, Lowery F, Syrigos K, Frangia K, Zolota V, Panagopoulos N, Dougenis D, Tanoue L, Detterbeck F, Homer R, Rimm D. Association of expression of bcl-2 with outcome in non-small cell lung cancer. Journal Of Clinical Oncology 2009, 27: e22039-e22039. DOI: 10.1200/jco.2009.27.15_suppl.e22039.Peer-Reviewed Original ResearchLung cancer patientsSquamous cell carcinomaBcl-2 expressionCancer patientsCell carcinomaBcl-2Non-small cell lung cancerYale-New Haven HospitalIndependent lower riskPatras University HospitalMedian overall survivalProtein expressionPotential prognostic parametersSubgroup of patientsCell lung cancerHigh Bcl-2 expressionNew Haven HospitalBcl-2 protein expressionAssociation of expressionBcl-2 protein levelsOverall survivalPatient survivalValidation cohortPathological characteristicsPrognostic parameters