2007
Differences in Risk Factors for Breast Cancer Molecular Subtypes in a Population-Based Study
Yang XR, Sherman ME, Rimm DL, Lissowska J, Brinton LA, Peplonska B, Hewitt SM, Anderson WF, Szeszenia-Dąbrowska N, Bardin-Mikolajczak A, Zatonski W, Cartun R, Mandich D, Rymkiewicz G, Ligaj M, Lukaszek S, Kordek R, García-Closas M. Differences in Risk Factors for Breast Cancer Molecular Subtypes in a Population-Based Study. Cancer Epidemiology Biomarkers & Prevention 2007, 16: 439-443. PMID: 17372238, DOI: 10.1158/1055-9965.epi-06-0806.Peer-Reviewed Original ResearchConceptsBasal-like tumorsMolecular subtypesBreast cancerClinical featuresRisk factorsRelative riskBreast cancer risk factorsBreast cancer molecular subtypesHuman epidermal growth factor receptorUnfavorable clinical featuresInvasive breast cancerBody mass indexCancer risk factorsDistinct clinical featuresCancer molecular subtypesEstrogen receptor alphaEpidermal growth factor receptorBreast Cancer StudyPolish Breast Cancer StudyGrowth factor receptorPremenopausal womenMass indexPathologic featuresProgesterone receptorOdds ratio
2005
Automated Quantitative Analysis (AQUA) of In Situ Protein Expression, Antibody Concentration, and Prognosis
McCabe A, Dolled-Filhart M, Camp RL, Rimm DL. Automated Quantitative Analysis (AQUA) of In Situ Protein Expression, Antibody Concentration, and Prognosis. Journal Of The National Cancer Institute 2005, 97: 1808-1815. PMID: 16368942, DOI: 10.1093/jnci/dji427.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntibodies, NeoplasmBiomarkers, TumorCell Line, TumorConfidence IntervalsEnzyme-Linked Immunosorbent AssayFemaleFluorescent Antibody TechniqueGene Expression ProfilingGene Expression Regulation, NeoplasticHumansImmunohistochemistryMaleMiddle AgedNeoplasmsOdds RatioPredictive Value of TestsPrognosisProtein Array AnalysisReceptor, ErbB-2Receptors, EstrogenSurvival AnalysisTreatment OutcomeTumor Suppressor Protein p53ConceptsDisease-specific mortalityHigh HER2 expressionHER2 expressionAntibody concentrationsHigh expressionPoor survivalRelative riskTissue microarrayCumulative disease-specific survivalBiomarker expressionLong-term survival dataLow expressionHER2 antibodyX-tile programDisease-specific survivalLow HER2 expressionKaplan-Meier methodBreast cancer patientsExpression of HER2Higher antibody concentrationsLow antibody concentrationsConcentration of antibodyCancer patientsPatient outcomesSitu protein expressionPatterns of reduced nipple aspirate fluid production and ductal lavage cellularity in women at high risk for breast cancer
Higgins SA, Matloff ET, Rimm DL, Dziura J, Haffty BG, King BL. Patterns of reduced nipple aspirate fluid production and ductal lavage cellularity in women at high risk for breast cancer. Breast Cancer Research 2005, 7: r1017. PMID: 16280052, PMCID: PMC1410733, DOI: 10.1186/bcr1335.Peer-Reviewed Original ResearchConceptsHigh-risk womenFluid-yielding ductsPrevious multicenter trialsMulticenter trialBreast cancerDuctal lavageLavage cellularityPresent seriesNAF productionSelective estrogen receptor modulatorsRisk-reducing therapiesRisk reduction therapyBRCA germline mutationsEstrogen receptor modulatorsBRCA-positive womenBreast cancer developmentEvaluation of abnormalitiesPostmenopausal statusHealthy womenBreast fluidIntraductal approachReceptor modulatorsRelative riskDuctal orificeReduction therapy
1999
Met expression is associated with poor outcome in patients with axillary lymph node negative breast carcinoma
Camp R, Rimm E, Rimm D. Met expression is associated with poor outcome in patients with axillary lymph node negative breast carcinoma. Cancer 1999, 86: 2259-2265. PMID: 10590366, DOI: 10.1002/(sici)1097-0142(19991201)86:11<2259::aid-cncr13>3.0.co;2-2.Peer-Reviewed Original ResearchConceptsAxillary lymph node negative breast carcinomaLymph node negative breast carcinomaExpression of METNode-negative breast carcinomaNegative breast carcinomaBreast carcinomaMET expressionMetastatic diseaseRelative riskNegative invasive ductal carcinomaLow Met expressionMET-negative patientsIndependent predictive valueIndependent prognostic markerUseful prognostic indicatorInvasive ductal carcinomaStandard immunoperoxidase techniqueHigh MET expressionHepatocyte growth factorActivation of METAxillary lymphNegative patientsPatient agePrognostic factorsAggressive disease