2014
Preanalytical variables and phosphoepitope expression in FFPE tissue: quantitative epitope assessment after variable cold ischemic time
Vassilakopoulou M, Parisi F, Siddiqui S, England AM, Zarella ER, Anagnostou V, Kluger Y, Hicks DG, Rimm DL, Neumeister VM. Preanalytical variables and phosphoepitope expression in FFPE tissue: quantitative epitope assessment after variable cold ischemic time. Laboratory Investigation 2014, 95: 334-341. PMID: 25418580, DOI: 10.1038/labinvest.2014.139.Peer-Reviewed Original ResearchConceptsCold ischemic timeIschemic timeFormalin fixationCompanion diagnostic testingCancer patientsBreast cancerTissue microarrayPhospho-HSP27Breast tumorsDiagnostic testingQuantitative immunofluorescenceAQUA technologyPreanalytical variablesGene expression profilingLoss of antigenicityTissue samplesReproducible assessmentProtein levelsConfidence intervalsSpecimen collectionExpression levelsPhosphorylation levelsAntigenicityRoutine usageResearch settings
2013
Tissue microarrays: leaping the gap between research and clinical adoption
Gustavson MD, Rimm DL, Dolled-Filhart M. Tissue microarrays: leaping the gap between research and clinical adoption. Personalized Medicine 2013, 10: 441-451. PMID: 29758838, DOI: 10.2217/pme.13.42.Peer-Reviewed Original ResearchTissue microarrayClinical laboratory settingUse of TMAsRoutine diagnostic purposesAdvanced imagingClinical settingPatient samplesDiagnostic useTissue assessmentTranslational research settingsExpression assessmentClinical research applicationsBiomarker analysisDiagnostic assaysDiagnostic purposesResearch settingsClinical adoption