2022
Association of PD-1/PD-L1 Co-location with Immunotherapy Outcomes in Non-Small Cell Lung Cancer
Gavrielatou N, Liu Y, Vathiotis I, Zugazagoitia J, Aung TN, Shafi S, Fernandez A, Schalper K, Psyrri A, Rimm DL. Association of PD-1/PD-L1 Co-location with Immunotherapy Outcomes in Non-Small Cell Lung Cancer. Clinical Cancer Research 2022, 28: clincanres.2649.2021. PMID: 34686497, PMCID: PMC8776595, DOI: 10.1158/1078-0432.ccr-21-2649.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerBest overall responsePD-L1 tumor proportion scorePD-1/PD-L1Immune checkpoint inhibitorsProgression-free survivalTumor proportion scoreCell lung cancerPD-L1Immunotherapy outcomesCheckpoint inhibitorsOverall survivalQuantitative immunofluorescenceLung cancerProportion scoreAdvanced non-small cell lung cancerLocal T cell responsesCell death protein 1Immunotherapy-treated patientsMultiplexed quantitative immunofluorescencePD-1 expressionPD-L1 expressionDeath protein 1Selection of patientsT cell responses
2021
PD-L1 as a biomarker of response to immune-checkpoint inhibitors
Doroshow DB, Bhalla S, Beasley MB, Sholl LM, Kerr KM, Gnjatic S, Wistuba II, Rimm DL, Tsao MS, Hirsch FR. PD-L1 as a biomarker of response to immune-checkpoint inhibitors. Nature Reviews Clinical Oncology 2021, 18: 345-362. PMID: 33580222, DOI: 10.1038/s41571-021-00473-5.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsSelection of patientsPD-L1L1 antibodyImmunohistochemistry assaysPD-L1 immunohistochemistry assaysOutcomes of patientsBiomarkers of responseCompanion diagnostic assayTypes of cancerPD-1Clinical outcomesSelection biomarkerProspective comparisonClinical challengeNew therapiesFuture treatmentPatientsSolid tumorsClinical useSpecific agentsInter-assay variabilityBiomarkersCurrent roleDiagnostic assays
2013
In situ techniques for protein analysis in tumor tissue
Anagnostou V, Rimm D. In situ techniques for protein analysis in tumor tissue. 2013, 76-84. DOI: 10.1017/cbo9781139046947.010.Peer-Reviewed Original ResearchSignal amplification techniqueProtein detectionAntigen of interestConventional IHCAntigen-antibody reactionLow costHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Growth factor receptor 2Selection of patientsComplementary diagnostic informationSitu techniquesFactor receptor 2Companion diagnostic testsCurrent analytical techniquesParaffin-embedded tissuesHistological diagnosisSpecific therapyDefinite diagnosisHistological subclassificationBreast cancerPrognostic biomarkerEstrogen receptorReceptor 2Morphologic evaluation
1997
Degree of dysplasia following diagnosis of atypical squamous cells of undetermined significance is influenced by patient history and type of follow‐up
Ghoussoub R, Rimm D. Degree of dysplasia following diagnosis of atypical squamous cells of undetermined significance is influenced by patient history and type of follow‐up. Diagnostic Cytopathology 1997, 17: 14-19. PMID: 9218897, DOI: 10.1002/(sici)1097-0339(199707)17:1<14::aid-dc3>3.0.co;2-p.Peer-Reviewed Original ResearchConceptsHigh-grade lesionsAtypical squamous cellsSelection of patientsGrade lesionsSquamous cellsUndetermined significanceDiagnosis of ASCUSSignificant past historyDegree of dysplasiaBethesda System criteriaASCUS diagnosisRetrospective studySignificant lesionsPatient historyVaginal smearsBiopsyCurrent literature findingsPatientsLesions