2018
Utility of CD8 score by automated quantitative image analysis in head and neck squamous cell carcinoma
Hartman DJ, Ahmad F, Ferris R, Rimm D, Pantanowitz L. Utility of CD8 score by automated quantitative image analysis in head and neck squamous cell carcinoma. Oral Oncology 2018, 86: 278-287. PMID: 30409313, PMCID: PMC6260977, DOI: 10.1016/j.oraloncology.2018.10.005.Peer-Reviewed Original ResearchConceptsCD8 T cellsImmune cell densityOropharyngeal HNSCCT cellsNeck squamous cell carcinomaCD8 cell densityImmune cell infiltratesSquamous cell carcinomaWhole tissue sectionsEntire tumor sectionHPV infectionMedian survivalCell infiltrateHNSCC patientsCell carcinomaHNSCC casesClinicopathologic parametersOnly predictorTumor sectionsBetter outcomesClinical practiceTumor microenvironmentCell densityClinical validationCells/
2014
The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014
Salgado R, Denkert C, Demaria S, Sirtaine N, Klauschen F, Pruneri G, Wienert S, Van den Eynden G, Baehner FL, Penault-Llorca F, Perez EA, Thompson EA, Symmans WF, Richardson AL, Brock J, Criscitiello C, Bailey H, Ignatiadis M, Floris G, Sparano J, Kos Z, Nielsen T, Rimm DL, Allison KH, Reis-Filho JS, Loibl S, Sotiriou C, Viale G, Badve S, Adams S, Willard-Gallo K, Loi S. The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014. Annals Of Oncology 2014, 26: 259-271. PMID: 25214542, PMCID: PMC6267863, DOI: 10.1093/annonc/mdu450.Peer-Reviewed Original ResearchConceptsTumor-infiltrating lymphocytesBreast cancerInternational TILs Working Group 2014Human epidermal growth factor receptor 2Epidermal growth factor receptor 2Growth factor receptor 2Evaluation of hematoxylinFactor receptor 2Immunological biomarkersLymphocytic infiltrationClinical trialsReceptor 2Clinical relevanceClinical validityTumor sectionsPredictive valueTumor tissueStandardized methodologyHistopathological practiceMorphological evaluationLymphocytesCancerCurrent dataFuture studiesVisual assessment