2014
Automated Objective Determination of Percentage of Malignant Nuclei for Mutation Testing
Viray H, Coulter M, Li K, Lane K, Madan A, Mitchell K, Schalper K, Hoyt C, Rimm DL. Automated Objective Determination of Percentage of Malignant Nuclei for Mutation Testing. Applied Immunohistochemistry & Molecular Morphology 2014, 22: 363-371. PMID: 24162261, PMCID: PMC3999345, DOI: 10.1097/pai.0b013e318299a1f6.Peer-Reviewed Original ResearchConceptsCriterion standardMalignant cellsMalignant nucleiCompanion diagnostic testsTumor cell percentageMutation testingEosin-stained tissuesCell percentageInForm softwareHistologic specimensTumor tissueColon adenocarcinomaTumor cellsDiagnostic testsPotential future toolDNA mutation testingTissue sectionsContinuous variablesFurther validationPathologist estimationAnalytic sensitivityVariant resultsDNA mutationsBenign nucleiTissue
2009
Quantitative, Fluorescence-Based In-Situ Assessment of Protein Expression
Moeder CB, Giltnane JM, Moulis SP, Rimm DL. Quantitative, Fluorescence-Based In-Situ Assessment of Protein Expression. Methods In Molecular Biology 2009, 520: 163-175. PMID: 19381954, DOI: 10.1007/978-1-60327-811-9_12.Peer-Reviewed Original Research
2007
Dr. David Rimm is interviewed by Feras Akbik.
Rimm D. Dr. David Rimm is interviewed by Feras Akbik. The Yale Journal Of Biology And Medicine 2007, 80: 183-5. PMID: 18449386, PMCID: PMC2347361.Peer-Reviewed Original Research
2006
Cruella: developing a scalable tissue microarray data management system.
Cowan JD, Rimm DL, Tuck DP. Cruella: developing a scalable tissue microarray data management system. Archives Of Pathology & Laboratory Medicine 2006, 130: 817-22. PMID: 16740033, DOI: 10.5858/2006-130-817-cdastm.Peer-Reviewed Original ResearchConceptsObject-relational database modelData elementsManagement systemMicroarray data storageMetadata-driven approachNew data modelData management systemDifferent data elementsJava ServletsPersistence layerDatabase schemaUser interactionDatabase modelWeb interfaceVocabulary standardsData modelCustom JavaData storageData typesDozens of researchersDynamic integrationAnalysis algorithmDifferent clinical investigatorsSpecial requirementsData System
2004
X-TileA New Bio-Informatics Tool for Biomarker Assessment and Outcome-Based Cut-Point Optimization
Camp RL, Dolled-Filhart M, Rimm DL. X-TileA New Bio-Informatics Tool for Biomarker Assessment and Outcome-Based Cut-Point Optimization. Clinical Cancer Research 2004, 10: 7252-7259. PMID: 15534099, DOI: 10.1158/1078-0432.ccr-04-0713.Peer-Reviewed Original Research