2017
Pathway level alterations rather than mutations in single genes predict response to HER2-targeted therapies in the neo-ALTTO trial
Shi W, Jiang T, Nuciforo P, Hatzis C, Holmes E, Harbeck N, Sotiriou C, Peña L, Loi S, Rosa DD, Chia S, Wardley A, Ueno T, Rossari J, Eidtmann H, Armour A, Piccart-Gebhart M, Rimm DL, Baselga J, Pusztai L. Pathway level alterations rather than mutations in single genes predict response to HER2-targeted therapies in the neo-ALTTO trial. Annals Of Oncology 2017, 28: 128-135. PMID: 28177460, PMCID: PMC5834036, DOI: 10.1093/annonc/mdw434.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Combined Chemotherapy ProtocolsBiopsy, Fine-NeedleBreast NeoplasmsClass I Phosphatidylinositol 3-KinasesDNA, NeoplasmExome SequencingFemaleHumansLapatinibMolecular Targeted TherapyMutationProportional Hazards ModelsProtein Kinase InhibitorsQuinazolinesReceptor, ErbB-2RhoA GTP-Binding ProteinTrastuzumabConceptsPathologic complete response
2014
Identification of proteomic biomarkers predicting prostate cancer aggressiveness and lethality despite biopsy-sampling error
Shipitsin M, Small C, Choudhury S, Giladi E, Friedlander S, Nardone J, Hussain S, Hurley AD, Ernst C, Huang YE, Chang H, Nifong TP, Rimm DL, Dunyak J, Loda M, Berman DM, Blume-Jensen P. Identification of proteomic biomarkers predicting prostate cancer aggressiveness and lethality despite biopsy-sampling error. British Journal Of Cancer 2014, 111: 1201-1212. PMID: 25032733, PMCID: PMC4453845, DOI: 10.1038/bjc.2014.396.Peer-Reviewed Original ResearchMeSH KeywordsActininAgedAlkyl and Aryl TransferasesArea Under CurveBiomarkers, TumorBiopsy, Fine-NeedleCullin ProteinsDNA-Binding ProteinsFollow-Up StudiesHSP70 Heat-Shock ProteinsHumansImage Processing, Computer-AssistedMaleMembrane ProteinsMiddle AgedMitochondrial ProteinsNeoplasm GradingNeoplasm StagingPhosphorylationProstateProstatic NeoplasmsProteomicsRibosomal Protein S6RNA-Binding Protein FUSROC CurveSelection BiasSmad2 ProteinSmad4 ProteinTissue Array AnalysisVoltage-Dependent Anion Channel 1Y-Box-Binding Protein 1ConceptsProstate cancer aggressivenessCancer aggressivenessLarge patient cohortLow Gleason gradePatient cohortTumor microarrayLethal outcomeProstatectomy samplesGleason gradeSignificant overtreatmentBiopsy interpretationProstatectomy tissuePatient samplesBiopsy testsProteomic biomarkersCancer biomarker discoveryExpert pathologistsMarker signaturesTumor heterogeneityBiomarkersAggressivenessProtein biomarkersBiomarker discoveryQuantitative proteomics approach
2012
Spatial spectral imaging as an adjunct to the Bethesda classification of thyroid fine‐needle aspiration specimens
Hahn LD, Hoyt C, Rimm DL, Theoharis C. Spatial spectral imaging as an adjunct to the Bethesda classification of thyroid fine‐needle aspiration specimens. Cancer Cytopathology 2012, 121: 162-167. PMID: 22833451, DOI: 10.1002/cncy.21224.Peer-Reviewed Original Research
2006
The value of onsite adequacy assessment of thyroid fine‐needle aspirations is a function of operator experience
Ghofrani M, Beckman D, Rimm DL. The value of onsite adequacy assessment of thyroid fine‐needle aspirations is a function of operator experience. Cancer 2006, 108: 110-113. PMID: 16400635, DOI: 10.1002/cncr.21715.Peer-Reviewed Original ResearchMeSH KeywordsBiopsy, Fine-NeedleFemaleHumansMaleMiddle AgedSpecimen HandlingThyroid DiseasesThyroid GlandThyroid NeoplasmsUltrasonographyConceptsFine-needle aspirationThyroid fine-needle aspirationPalpation-guided fine-needle aspirationNondiagnostic rateOnsite evaluationUS guidancePerformance of FNAImmediate adequacy assessmentCurrent studyLower nondiagnostic rateFinal diagnosisChi-square analysisCytologic diagnosisNondiagnostic specimensNondiagnostic aspiratesPalpationSignificant decreaseDiagnosisImmediate evaluationExperienced radiologistsRadiologistsOperator experienceExperienced operatorsAdequate materialLess experience
2005
Fine Needle Aspiration Is a Feasible and Accurate Technique in the Diagnosis of Lymphoma
Austin R, Birdsong G, Sidawy M, Kaminsky D, Benstein B, Cibas E, Mody D, Guidos B, Moriarty A, Rimm D, Ehya H, Facik M, Howell L, Gill G, Kurtycz D, Powers C, Young N. Fine Needle Aspiration Is a Feasible and Accurate Technique in the Diagnosis of Lymphoma. Journal Of Clinical Oncology 2005, 23: 9029-9030. PMID: 16339755, DOI: 10.1200/jco.2005.01.5248.Peer-Reviewed Original Research
2004
Novel tyramide‐based tyrosinase assay for the detection of melanoma cells in cytological preparations
Angeletti C, Khomitch V, Halaban R, Rimm DL. Novel tyramide‐based tyrosinase assay for the detection of melanoma cells in cytological preparations. Diagnostic Cytopathology 2004, 31: 33-37. PMID: 15236262, DOI: 10.1002/dc.20051.Peer-Reviewed Original Research