2012
Measurement of Aldehyde Dehydrogenase 1 Expression Defines a Group with Better Prognosis in Patients with Non-Small Cell Lung Cancer
Dimou A, Neumeister V, Agarwal S, Anagnostou V, Syrigos K, Rimm DL. Measurement of Aldehyde Dehydrogenase 1 Expression Defines a Group with Better Prognosis in Patients with Non-Small Cell Lung Cancer. American Journal Of Pathology 2012, 181: 1436-1442. PMID: 22877687, DOI: 10.1016/j.ajpath.2012.06.037.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerAldehyde dehydrogenase 1Cell lung cancerALDH1 expressionBetter prognosisLung cancerBreast cancerYale cohortQuantitative immunofluorescenceAldehyde dehydrogenase 1 (ALDH1) expressionPatras University HospitalSquamous cell carcinomaCancer stem cellsClinicopathologic factorsPoor outcomePrognostic valueRetrospective studyShorter survivalCell carcinomaUniversity HospitalSurrogate biomarkerFavorable outcomeLarge cohortTissue microarrayPatients
2010
In Situ Identification of Putative Cancer Stem Cells by Multiplexing ALDH1, CD44, and Cytokeratin Identifies Breast Cancer Patients with Poor Prognosis
Neumeister V, Agarwal S, Bordeaux J, Camp RL, Rimm DL. In Situ Identification of Putative Cancer Stem Cells by Multiplexing ALDH1, CD44, and Cytokeratin Identifies Breast Cancer Patients with Poor Prognosis. American Journal Of Pathology 2010, 176: 2131-2138. PMID: 20228222, PMCID: PMC2861079, DOI: 10.2353/ajpath.2010.090712.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAldehyde DehydrogenaseAldehyde Dehydrogenase 1 FamilyBreast NeoplasmsFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansHyaluronan ReceptorsIsoenzymesKeratinsMiddle AgedNeoplastic Stem CellsPrognosisRetinal DehydrogenaseRetrospective StudiesConceptsCancer stem cellsPutative cancer stem cellsBreast cancerIdentifies high-risk patientsPresence of CSCsNode-positive patientsHigh-risk patientsBreast cancer patientsAggressive tumor behaviorParaffin-embedded breast cancer tissuesBreast cancer tissuesFlow cytometric studyStem cellsMean followNodal statusRisk patientsTumor persistenceCD44 positivityPoor prognosisPrognostic valueTumor sizeHistological gradeALDH1 positivityCancer patientsWorse outcomes
2009
Is ALDH1 a good method for definition of breast cancer stem cells?
Neumeister V, Rimm D. Is ALDH1 a good method for definition of breast cancer stem cells? Breast Cancer Research And Treatment 2009, 123: 109-111. PMID: 19946740, DOI: 10.1007/s10549-009-0656-y.Peer-Reviewed Original ResearchAldehyde DehydrogenaseAldehyde Dehydrogenase 1 FamilyBiomarkers, TumorBreast NeoplasmsFemaleHumansIsoenzymesNeoplastic Stem CellsRetinal Dehydrogenase