1999
Characterization of TCR gene rearrangements during adult murine T cell development.
Livák F, Tourigny M, Schatz D, Petrie H. Characterization of TCR gene rearrangements during adult murine T cell development. The Journal Of Immunology 1999, 162: 2575-80. PMID: 10072498, DOI: 10.4049/jimmunol.162.5.2575.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGene Rearrangement, beta-Chain T-Cell Antigen ReceptorGene Rearrangement, delta-Chain T-Cell Antigen ReceptorGene Rearrangement, gamma-Chain T-Cell Antigen ReceptorGene Rearrangement, T-LymphocyteHyaluronan ReceptorsMiceMice, Inbred C57BLPolymerase Chain ReactionReceptors, Interleukin-2T-LymphocytesConceptsTCRbeta locusTCRdelta locusGammadelta T cell lineagesMurine T cell developmentTCR gene rearrangementsT lineage cellsGene rearrangementsT cell developmentLineage decisionsLocus recombinationLineage commitmentProductive rearrangementsIrreversible commitmentCell lineagesDelta geneMolecular evidenceCell developmentTCRbeta rearrangementsDevelopmental stagesT-cell lineageTCR complexLociLineage cellsLineagesGenes
1991
Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking
Turka L, Schatz D, Oettinger M, Chun J, Gorka C, Lee K, McCormack W, Thompson C. Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking. Science 1991, 253: 778-781. PMID: 1831564, DOI: 10.1126/science.1831564.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteCD3 ComplexCell DifferentiationCell SurvivalDNA NucleotidyltransferasesDNA-Binding ProteinsGene ExpressionGene Rearrangement, T-LymphocyteHomeodomain ProteinsHumansMiceNuclear ProteinsNucleic Acid HybridizationProteinsReceptor AggregationReceptors, Antigen, T-CellReceptors, Interleukin-2RNA, MessengerT-Lymphocyte SubsetsThymus GlandVDJ RecombinasesConceptsMajor histocompatibility complexCortical thymocytesSelf-major histocompatibility complexT cell receptor expressionHLA class IRAG-2Cell receptor expressionTCR complexRAG expressionT cell developmentT cell surfaceThymic subpopulationsCD4-CD8Intact thymusReceptor expressionThymic maturationRAG-1RAG-2 expressionThymocyte TCRThymocyte maturationHistocompatibility complexClass IReceptor crossThymocyte expressionBlot analysis