The Role of RAG in V(D)J Recombination
Xiao J, Martin E, Wang K, Schatz D. The Role of RAG in V(D)J Recombination. 2024 DOI: 10.1016/b978-0-128-24465-4.00019-3.Peer-Reviewed Original ResearchRecombination signal sequencesRecombination activating geneV(D)J recombinationDNA cleavageConserved sequence elementsNonhomologous end-joining pathwayLymphoid-specific proteinsAntigen receptor gene segmentsEnd-joining pathwayPair of hairpinsReceptor gene segmentsTransposable elementsDomain architectureSequence elementsLocus structureSignal sequenceTransposition mechanismTranscriptional regulationJawed vertebratesTransposase activityActive genesPosttranslational modificationsEnhancer elementsProtein structureCell cycleChapter 2 The Mechanism, Regulation and Evolution of V(D)J Recombination
Schatz D, Zhang Y, Xiao J, Zha S, Zhang Y, Alt F. Chapter 2 The Mechanism, Regulation and Evolution of V(D)J Recombination. 2024, 13-57. DOI: 10.1016/b978-0-323-95895-0.00004-0.Peer-Reviewed Original ResearchAntigen receptor lociNon-homologous end joiningChromatin loop extrusionRecombination-activating geneLoop extrusionV(D)J recombinationRecombination-activating gene proteinV(D)J recombination reactionReceptor locusEnd joiningDouble-strand (ds) DNA breaksLoop extrusion mechanismRegulation of recombinationRepertoire of antigen receptorsLymphocyte developmentOncogenic chromosomal translocationsVariable region gene segmentsDNA repair proteinsDNA repair pathwaysChromatin accessibilityDNA segmentsV(D)J recombinase activitySubstrate DNALoop domainV(D)J junctions