Featured Publications
Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis
Moledina DG, Wilson FP, Pober JS, Perazella MA, Singh N, Luciano RL, Obeid W, Lin H, Kuperman M, Moeckel GW, Kashgarian M, Cantley LG, Parikh CR. Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis. JCI Insight 2019, 4: e127456. PMID: 31092735, PMCID: PMC6542610, DOI: 10.1172/jci.insight.127456.Peer-Reviewed Original ResearchConceptsAcute interstitial nephritisAcute kidney diseasePrebiopsy diagnosisKidney biopsyKidney diseaseIL-9AIN diagnosisUrine TNFInterstitial nephritisSpecific T cell subsetsAcute tubular injuryDiabetic kidney diseaseIL-9 levelsTNF-α levelsT cell subsetsAddition of biomarkersPlasma cytokinesCytokine levelsTubular injuryHighest quartileMultivariable analysisCell subsetsUrinary TNFBlood eosinophilsGlomerular disease
2017
Plasma Biomarkers and Kidney Function Decline in Early and Established Diabetic Kidney Disease
Coca SG, Nadkarni GN, Huang Y, Moledina DG, Rao V, Zhang J, Ferket B, Crowley ST, Fried LF, Parikh CR. Plasma Biomarkers and Kidney Function Decline in Early and Established Diabetic Kidney Disease. Journal Of The American Society Of Nephrology 2017, 28: 2786-2793. PMID: 28476763, PMCID: PMC5576932, DOI: 10.1681/asn.2016101101.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersCase-Control StudiesDiabetes Mellitus, Type 2Diabetic NephropathiesDisease ProgressionFemaleGlomerular Filtration RateHepatitis A Virus Cellular Receptor 1HumansMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesRandomized Controlled Trials as TopicReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIConceptsKidney injury molecule-1Diabetic kidney diseaseTNF receptor 1Progressive diabetic kidney diseaseRenal outcomesTNFR-2Kidney diseaseBaseline levelsAdvanced diabetic kidney diseaseIncident diabetic kidney diseaseKIM-1 levelsKidney function declineInjury molecule-1Prospective cohort studyBaseline plasma samplesBiomarkers of inflammationClinical prognostic modelDiverse pathophysiologic mechanismsType 2 diabetesCase-control studyHigher baseline levelsEGFR declineCohort studyFunction declinePathophysiologic mechanisms