2024
B-243 Validating a highly automated, rapid turnaround urine biomarker assay for diagnosis of acute interstitial nephritis
Obeid W, Moledina D, Parikh C. B-243 Validating a highly automated, rapid turnaround urine biomarker assay for diagnosis of acute interstitial nephritis. Clinical Chemistry 2024, 70: hvae106.600. DOI: 10.1093/clinchem/hvae106.600.Peer-Reviewed Original ResearchAcute interstitial nephritisDiagnosis of acute interstitial nephritisTNF-aMesoscale DiscoveryCXCL-9Urinary tumor necrosis factor-alphaInterstitial nephritisUrine biomarker assayTumor necrosis factor-alphaNecrosis factor-alphaSpike-recovery analysisFactor-alphaPotential diagnostic biomarkersLevels of QCBiomarker assaysDiagnostic biomarkersAssay diluentDilution linearityNephritisAverage recoverySpiking volumeHospital settingLigand 9UrineDiagnosis
2022
Urine testing to differentiate glomerular from tubulointerstitial diseases on kidney biopsy
Tran AC, Melchinger H, Weinstein J, Shaw M, Kent C, Perazella MA, Wilson FP, Parikh CR, Moledina DG. Urine testing to differentiate glomerular from tubulointerstitial diseases on kidney biopsy. Practical Laboratory Medicine 2022, 30: e00271. PMID: 35465621, PMCID: PMC9018443, DOI: 10.1016/j.plabm.2022.e00271.Peer-Reviewed Original ResearchTubulointerstitial diseaseKidney biopsyGlomerular diseaseUrine albuminHistological diagnosisUrine uromodulinUrine testsHigher urine albuminUrine sediment microscopyCohort of participantsDipstick hematuriaTubular injuryAppropriate patientsUrine testingMultivariable modelHigher oddsBiopsyClinical decisionSediment microscopyDiseasePatientsHealth biomarkersUrine samplesDiagnosisCohortClinical Features and Laboratory Findings in Acute Tubulointerstitial Nephritis
Kodali R, Moledina D. Clinical Features and Laboratory Findings in Acute Tubulointerstitial Nephritis. 2022, 245-255. DOI: 10.1007/978-3-030-93438-5_19.ChaptersAcute tubulointerstitial nephritisKidney functionTubulointerstitial nephritisEvaluation of urineNon-invasive testsPresenting featuresKidney biopsyClinical featuresMedication historyHistological diagnosisLaboratory findingsHigh indexClinical usePatientsDiagnosisCareful evaluationTemporal associationNephritisSubtle cluesBiopsyCliniciansDiseaseSuspicionUrine