Featured Publications
Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis
Melchinger H, Calderon-Gutierrez F, Obeid W, Xu L, Shaw MM, Luciano RL, Kuperman M, Moeckel GW, Kashgarian M, Wilson FP, Parikh CR, Moledina DG. Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis. Clinical Journal Of The American Society Of Nephrology 2022, 17: 1284-1292. PMID: 35948365, PMCID: PMC9625093, DOI: 10.2215/cjn.04360422.Peer-Reviewed Original ResearchConceptsInterstitial fibrosis/tubular atrophyUrine uromodulinTubular atrophyThick ascending limbUrine albuminSerum creatinineKidney biopsyTubulointerstitial fibrosisMultivariable linear regression modelsTime of biopsyKidney's thick ascending limbAcademic medical centerHuman kidney biopsiesKidney tubulointerstitial fibrosisTubular healthMultivariable analysisHistologic featuresHistologic findingsHistologic changesKidney fibrosisIndependent associationFibrotic modelMultivariable modelMedical CenterMurine model
2019
Association of T Cell–Derived Inflammatory Cytokines With Acute Kidney Injury and Mortality After Cardiac Surgery
Moledina DG, Mansour SG, Jia Y, Obeid W, Thiessen-Philbrook H, Koyner JL, McArthur E, Garg AX, Wilson FP, Shlipak MG, Coca SG, Parikh CR, Consortium T. Association of T Cell–Derived Inflammatory Cytokines With Acute Kidney Injury and Mortality After Cardiac Surgery. Kidney International Reports 2019, 4: 1689-1697. PMID: 31844805, PMCID: PMC6895592, DOI: 10.1016/j.ekir.2019.09.003.Peer-Reviewed Original ResearchAcute kidney injuryIschemia-reperfusion injuryCardiac surgeryKidney injuryIL-13IL-4Higher oddsT cell-derived inflammatory cytokinesPostoperative acute kidney injuryRenal ischemia-reperfusion injuryTh2 biomarkersObservational cohortPreoperative levelsT helperTh2 pathwayClinical outcomesTh2 cytokinesClinical variablesInflammatory cytokinesIndependent associationPlasma biomarkersTh2 cellsSurgeryAnimal modelsMortality
2015
Association of Perioperative Plasma Neutrophil Gelatinase-Associated Lipocalin Levels with 3-Year Mortality after Cardiac Surgery: A Prospective Observational Cohort Study
Moledina DG, Parikh CR, Garg AX, Thiessen-Philbrook H, Koyner JL, Patel UD, Devarajan P, Shlipak MG, Coca SG, . Association of Perioperative Plasma Neutrophil Gelatinase-Associated Lipocalin Levels with 3-Year Mortality after Cardiac Surgery: A Prospective Observational Cohort Study. PLOS ONE 2015, 10: e0129619. PMID: 26053382, PMCID: PMC4460181, DOI: 10.1371/journal.pone.0129619.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAcute-Phase ProteinsAgedAged, 80 and overBiomarkersCardiac Surgical ProceduresCause of DeathCohort StudiesCreatinineFemaleFollow-Up StudiesHumansKidney Function TestsLipocalin-2LipocalinsMaleMiddle AgedMortalityPerioperative PeriodProspective StudiesProto-Oncogene ProteinsRisk FactorsTime FactorsConceptsPlasma neutrophil gelatinase-associated lipocalinProspective observational cohort studyLong-term mortalityObservational cohort studySerum creatinineCardiac surgeryCohort studyIndependent associationPlasma neutrophil gelatinase associated lipocalin (NGAL) levelsNeutrophil Gelatinase-Associated Lipocalin LevelsShort-term adverse outcomesNeutrophil gelatinase-associated lipocalinAcute kidney injuryPre-operative variablesIntra-operative variablesGelatinase-associated lipocalinGlomerular filtration ratePre-operative levelsPeri-operative changesPost-operative dayTRIBE-AKI cohortLipocalin levelsCause mortalityKidney injuryNGAL levels