2024
COVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes
Aklilu A, Kumar S, Nugent J, Yamamoto Y, Coronel-Moreno C, Kadhim B, Faulkner S, O’Connor K, Yasmin F, Greenberg J, Moledina D, Testani J, Wilson F. COVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes. JAMA Internal Medicine 2024, 184: 414-423. PMID: 38407862, PMCID: PMC10897825, DOI: 10.1001/jamainternmed.2023.8225.Peer-Reviewed Original ResearchCOVID-19-associated acute kidney injuryCOVID-19-associated AKIAcute kidney injuryMulticenter cohort studyKidney function declineKidney functionKidney injuryCohort studyKidney outcomes of patientsIncidence of acute kidney injuryLong-term kidney outcomesHistorical cohort of patientsMultivariate time-to-event analysesPositive influenza ALongitudinal multicenter cohort studyWorsening kidney functionOutcomes of patientsAdverse kidney eventsCohort of patientsComposite of mortalityMarkers of illness severityAdult hospitalized patientsBaseline comorbidity scoreTime-to-event analysisFunctional decline
2021
Urinary EGF and MCP-1 and risk of CKD after cardiac surgery
Menez S, Ju W, Menon R, Moledina DG, Thiessen Philbrook H, McArthur E, Jia Y, Obeid W, Mansour SG, Koyner JL, Shlipak MG, Coca SG, Garg AX, Bomback AS, Kellum JA, Kretzler M, Parikh CR, . Urinary EGF and MCP-1 and risk of CKD after cardiac surgery. JCI Insight 2021, 6: e147464. PMID: 33974569, PMCID: PMC8262289, DOI: 10.1172/jci.insight.147464.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAged, 80 and overCardiac Surgical ProceduresChemokine CCL2Disease ProgressionEpidermal Growth FactorFemaleGene Expression ProfilingHumansIncidenceMalePostoperative ComplicationsProportional Hazards ModelsRenal Insufficiency, ChronicRNA, MessengerRNA-SeqSingle-Cell AnalysisConceptsAcute kidney injuryCardiac surgeryMCP-1CKD outcomesUrinary EGFLong-term kidney outcomesChronic kidney disease riskTRIBE-AKI (Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury) ConsortiumKidney disease riskMCP-1 levelsRisk of CKDAmerican Heart AssociationPostoperative urine samplesHealth Research InstituteLong-term careCKD incidenceKidney outcomesKidney injuryKidney Precision Medicine ProjectComposite outcomeTubular damageHeart AssociationCCL2 expressionGlomerular functionKidney Center
2020
Results from the TRIBE-AKI Study found associations between post-operative blood biomarkers and risk of chronic kidney disease after cardiac surgery
Menez S, Moledina DG, Garg AX, Thiessen-Philbrook H, McArthur E, Jia Y, Liu C, Obeid W, Mansour SG, Koyner JL, Shlipak MG, Wilson FP, Coca SG, Parikh CR. Results from the TRIBE-AKI Study found associations between post-operative blood biomarkers and risk of chronic kidney disease after cardiac surgery. Kidney International 2020, 99: 716-724. PMID: 32721447, PMCID: PMC8077034, DOI: 10.1016/j.kint.2020.06.037.Peer-Reviewed Original ResearchConceptsEstimated glomerular filtration rateChronic kidney diseaseBaseline estimated glomerular filtration rateCardiac surgeryCKD incidenceKidney diseaseBlood biomarkersN-terminal pro-B-type natriuretic peptideDevelopment of CKDPro-B-type natriuretic peptideReplication cohortAcute kidney injury groupLong-term kidney outcomesKidney injury molecule-1Acute kidney injuryPrimary composite outcomeInjury molecule-1Post-operative levelsGlomerular filtration rateTumor necrosis factor receptor 1Necrosis factor receptor 1Basic fibroblast growth factorFactor receptor 1Fibroblast growth factorAKI studies