2022
Pre-operative kidney biomarkers and risks for death, cardiovascular and chronic kidney disease events after cardiac surgery: the TRIBE-AKI study
Vasquez-Rios G, Moledina D, Jia Y, McArthur E, Mansour S, Thiessen-Philbrook H, Shlipak M, Koyner J, Garg A, Parikh C, Coca S. Pre-operative kidney biomarkers and risks for death, cardiovascular and chronic kidney disease events after cardiac surgery: the TRIBE-AKI study. Journal Of Cardiothoracic Surgery 2022, 17: 338. PMID: 36567329, PMCID: PMC9790121, DOI: 10.1186/s13019-022-02066-4.Peer-Reviewed Original ResearchConceptsKidney injury molecule-1Cardiovascular eventsCardiac surgeryCKD eventsCohort studyPlasma kidney injury molecule-1Chronic kidney disease (CKD) incidenceKidney disease incidenceKidney function dataPre-operative concentrationsInjury molecule-1Evaluation of patientsHigh-risk adultsLong-term outcomesHigh-risk individualsTumor necrosis factor receptorNecrosis factor receptorKidney eventsMedian followPlasma sTNFR1Hazard ratioClinical outcomesKidney biomarkersPlasma biomarkersClinical covariates
2020
Association Between Early Recovery of Kidney Function After Acute Kidney Injury and Long-term Clinical Outcomes
Bhatraju PK, Zelnick LR, Chinchilli VM, Moledina DG, Coca SG, Parikh CR, Garg AX, Hsu CY, Go AS, Liu KD, Ikizler TA, Siew ED, Kaufman JS, Kimmel PL, Himmelfarb J, Wurfel MM. Association Between Early Recovery of Kidney Function After Acute Kidney Injury and Long-term Clinical Outcomes. JAMA Network Open 2020, 3: e202682. PMID: 32282046, PMCID: PMC7154800, DOI: 10.1001/jamanetworkopen.2020.2682.Peer-Reviewed Original ResearchConceptsMajor adverse kidney eventsAcute kidney injuryProgressive chronic kidney diseaseChronic kidney diseaseKidney function recoverySerum creatinine concentrationKidney injuryClinical outcomesFunction recoveryKidney diseaseCreatinine concentrationHigh riskLong-term clinical outcomesAdverse kidney eventsAdjusted hazard ratioMulticenter cohort studyGlomerular filtration rateLong-term dialysisPopulation of patientsLong-term outcomesPatient risk stratificationRecognition of patientsLong-term riskAKI diagnosisAKI severity
2019
The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery
Mansour SG, Zhang WR, Moledina D, Coca SG, Jia Y, Thiessen-Philbrook H, McArthur E, Inoue K, Koyner JL, Shlipak MG, Wilson FP, Garg AX, Ishibe S, Parikh CR, Consortium T. The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery. American Journal Of Kidney Diseases 2019, 74: 36-46. PMID: 30955944, PMCID: PMC6591032, DOI: 10.1053/j.ajkd.2019.01.028.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedBiomarkersCardiac Surgical ProceduresCreatinineEndpoint DeterminationFemaleHumansKidneyMaleMiddle AgedNeovascularization, PhysiologicOutcome Assessment, Health CarePostoperative ComplicationsProspective StudiesReceptors, Vascular Endothelial Growth FactorRisk AssessmentUnited StatesVascular Endothelial Growth Factor AConceptsAcute kidney injuryCardiac surgeryAKI durationKidney injuryProangiogenic markersAngiogenesis markersOutcomes of AKILong-term outcomesPlasma VEGF concentrationsTRIBE-AKI cohortAntiangiogenic markersCause mortalityPreoperative concentrationsHospital dischargeProcess of angiogenesisMarker levelsVEGFR1 levelsPGF concentrationsHigher oddsMortality riskHigh riskLower oddsVEGF concentrationsAngiogenic markersSurgery
2018
Phenotyping of Acute Kidney Injury: Beyond Serum Creatinine
Moledina DG, Parikh CR. Phenotyping of Acute Kidney Injury: Beyond Serum Creatinine. Seminars In Nephrology 2018, 38: 3-11. PMID: 29291759, PMCID: PMC5753429, DOI: 10.1016/j.semnephrol.2017.09.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAcute kidney injuryKidney injuryAKI definitionSerum creatinineStructural kidney injuryGlomerular filtration rateLong-term outcomesAKI phenotypesCommon complicationHospitalized patientsFiltration rateDifferent therapiesConsensus definitionInjuryLack sensitivityMolecular pathwaysCreatinineDistinct phenotypesHeterogeneous conditionPhenotypeComplicationsPatientsPrognosisTherapyEtiology