Featured Publications
Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
Moledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2023, 133: e168950. PMID: 37395276, PMCID: PMC10313360, DOI: 10.1172/jci168950.Peer-Reviewed Original ResearchConceptsUrinary CXCL9External validation cohortValidation cohortControl groupAIN diagnosisDiscovery cohortKidney tissueDiagnostic biomarkersAcute interstitial nephritisCXCL9 mRNA expressionAcute kidney injuryBiopsy-confirmed diagnosisAvailable clinical testsNational InstituteKidney injuryTubulointerstitial nephritisInterstitial nephritisKidney biopsyHistological confirmationHistological diagnosisTreatment optionsLymphocyte chemotaxisCXCL9MRNA expression differencesPatientsDevelopment and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data
Moledina DG, Eadon MT, Calderon F, Yamamoto Y, Shaw M, Perazella MA, Simonov M, Luciano R, Schwantes-An TH, Moeckel G, Kashgarian M, Kuperman M, Obeid W, Cantley LG, Parikh CR, Wilson FP. Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data. Nephrology Dialysis Transplantation 2021, 37: 2214-2222. PMID: 34865148, PMCID: PMC9755995, DOI: 10.1093/ndt/gfab346.Peer-Reviewed Original ResearchConceptsAcute interstitial nephritisInterstitial nephritisUrine biomarkersBiopsy-proven acute interstitial nephritisElectronic health record dataExternal validation cohortTypical clinical featuresBlood urea nitrogenTumor necrosis factorCharacteristic curve analysisHealth record dataExternal validationElectronic health recordsAIN diagnosisModest AUCsSerum creatinineCreatinine ratioKidney biopsyClinical featuresValidation cohortNecrosis factorUnrecognized casesInterleukin-9PatientsUrea nitrogenUrine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis
Moledina DG, Wilson FP, Kukova L, Obeid W, Luciano R, Kuperman M, Moeckel GW, Kashgarian M, Perazella MA, Cantley LG, Parikh CR. Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis. Nephrology Dialysis Transplantation 2020, 36: 1851-1858. PMID: 33125471, PMCID: PMC8476079, DOI: 10.1093/ndt/gfaa169.Peer-Reviewed Original ResearchConceptsAcute interstitial nephritisTumor necrosis factorCorticosteroid useIL-9Interstitial nephritisNecrosis factorAcute kidney injuryIL-9 levelsGlomerular filtration rateSubset of patientsCohort of participantsImmunosuppressive therapyTubulointerstitial infiltratesKidney injuryMedian eGFRKidney functionUrine biomarkersInterstitial fibrosisFiltration rateHistological featuresClinical trialsInterleukin-9PatientsEGFRComplete data
2024
Urinary Plasminogen as a Marker of Disease Progression in Human Glomerular Disease
de Cos M, Mosoyan G, Chauhan K, Troost J, Wong J, Lefferts S, Morgan P, Meliambro K, Egerman M, Ray J, Parker T, Levine D, Seshan S, Bardash Y, Horowitz B, Kent C, Shaw M, Perlman A, Moledina D, Coca S, Campbell K. Urinary Plasminogen as a Marker of Disease Progression in Human Glomerular Disease. American Journal Of Kidney Diseases 2024, 84: 205-214.e1. PMID: 38452919, PMCID: PMC11260534, DOI: 10.1053/j.ajkd.2024.01.520.Peer-Reviewed Original ResearchAssociated with end-stage kidney diseaseEnd-stage kidney diseaseUrinary plasmin(ogenGlomerular diseaseGlomerular disordersBiopsy-proven glomerular diseaseVariable clinical courseDevelopment of novel therapiesCohort of patientsRestricted to patientsElectro-chemiluminescence immunoassayHuman glomerular diseasesClinical courseUrinary markersUrine creatinineAbstractText Label="RATIONALENovel therapiesPrognostic decision makingCox regressionWhite patientsDisease progressionKidney diseasePatientsPodocyte injuryCohort
2022
Safety and Adequacy of Kidney Biopsy Procedure in Patients with Obesity
Qian L, Menez S, Hu D, Weinstein J, Melchinger H, Thiessen-Philbrook H, Luciano R, Turner J, Perazella M, Villalobos C, Shaw M, Wilson F, Parikh C, Moledina D. Safety and Adequacy of Kidney Biopsy Procedure in Patients with Obesity. Kidney360 2022, 4: 98-101. PMID: 36700910, PMCID: PMC10101611, DOI: 10.34067/kid.0006602022.Peer-Reviewed Original ResearchUrine testing to differentiate glomerular from tubulointerstitial diseases on kidney biopsy
Tran AC, Melchinger H, Weinstein J, Shaw M, Kent C, Perazella MA, Wilson FP, Parikh CR, Moledina DG. Urine testing to differentiate glomerular from tubulointerstitial diseases on kidney biopsy. Practical Laboratory Medicine 2022, 30: e00271. PMID: 35465621, PMCID: PMC9018443, DOI: 10.1016/j.plabm.2022.e00271.Peer-Reviewed Original ResearchTubulointerstitial diseaseKidney biopsyGlomerular diseaseUrine albuminHistological diagnosisUrine uromodulinUrine testsHigher urine albuminUrine sediment microscopyCohort of participantsDipstick hematuriaTubular injuryAppropriate patientsUrine testingMultivariable modelHigher oddsBiopsyClinical decisionSediment microscopyDiseasePatientsHealth biomarkersUrine samplesDiagnosisCohortClinical Features and Laboratory Findings in Acute Tubulointerstitial Nephritis
Kodali R, Moledina D. Clinical Features and Laboratory Findings in Acute Tubulointerstitial Nephritis. 2022, 245-255. DOI: 10.1007/978-3-030-93438-5_19.ChaptersAcute tubulointerstitial nephritisKidney functionTubulointerstitial nephritisEvaluation of urineNon-invasive testsPresenting featuresKidney biopsyClinical featuresMedication historyHistological diagnosisLaboratory findingsHigh indexClinical usePatientsDiagnosisCareful evaluationTemporal associationNephritisSubtle cluesBiopsyCliniciansDiseaseSuspicionUrine
2021
Rationale and design of the Kidney Precision Medicine Project
de Boer IH, Alpers CE, Azeloglu EU, Balis UGJ, Barasch JM, Barisoni L, Blank KN, Bomback AS, Brown K, Dagher PC, Dighe AL, Eadon MT, El-Achkar TM, Gaut JP, Hacohen N, He Y, Hodgin JB, Jain S, Kellum JA, Kiryluk K, Knight R, Laszik ZG, Lienczewski C, Mariani LH, McClelland RL, Menez S, Moledina DG, Mooney SD, O’Toole J, Palevsky PM, Parikh CR, Poggio ED, Rosas SE, Rosengart MR, Sarwal MM, Schaub JA, Sedor JR, Sharma K, Steck B, Toto RD, Troyanskaya OG, Tuttle KR, Vazquez MA, Waikar SS, Williams K, Wilson FP, Zhang K, Iyengar R, Kretzler M, Himmelfarb J, Project K, Knight R, Lecker S, Stillman I, Waikar S, Mcmahon G, Weins A, Short S, Hacohen N, Hoover P, Aulisio M, Cooperman L, Herlitz L, O’Toole J, Poggio E, Sedor J, Jolly S, Appelbaum P, Balderes O, Barasch J, Bomback A, Canetta P, d’Agati V, Kiryluk K, Kudose S, Mehl K, Radhakrishnan J, Weng C, Barisoni L, Alexandrov T, Ashkar T, Barwinska D, Dagher P, Dunn K, Eadon M, Ferkowicz M, Kelly K, Sutton T, Winfree S, Menez S, Parikh C, Rosenberg A, Villalobos P, Malik R, Fine D, Atta M, Trujillo J, Slack A, Rosas S, Williams M, Azeloglu E, He C, Iyengar R, Hansen J, Parikh S, Rovin B, Anderton C, Pasa-Tolic L, Velickovic D, Lukowski J, Oliver G, Ardayfio J, Bebiak J, Brown K, Campbell T, Campbell C, Hayashi L, Jefferson N, Koewler R, Roberts G, Saul J, Shpigel A, Stutzke E, Wright L, Miegs L, Pinkeney R, Sealfon R, Troyanskaya O, Tuttle K, Dobi D, Goltsev Y, Lake B, Zhang K, Joanes M, Laszik Z, Schroeder A, Sarwal M, Sigdel T, Balis U, Blanc V, He O, Hodgin J, Kretzler M, Mariani L, Menon R, Otto E, Schaub J, Steck B, Lienczewski C, Eddy S, Elder M, Hall D, Kellum J, Kruth M, Murugan R, Palevsky P, Randhawa P, Rosengart M, Sims-Lucas S, Stefanick M, Stull S, Tublin M, Alpers C, de Boer I, Dighe A, Himmelfarb J, Mcclelland R, Mooney S, Shankland S, Williams K, Blank K, Carson J, Dowd F, Drager Z, Park C, Sharma K, Zhang G, Bansal S, Venkatachalam M, Kermani A, Lee S, Lu C, Miller T, Moe O, Park H, Sambandam K, Sanchez F, Torrealba J, Robert T, Vazquez M, Wang N, Gaut J, Jain S, Vijayan A, Luciano R, Moledina D, Ugochukwu U, Wilson F, Alfano S. Rationale and design of the Kidney Precision Medicine Project. Kidney International 2021, 99: 498-510. PMID: 33637194, PMCID: PMC8330551, DOI: 10.1016/j.kint.2020.08.039.Peer-Reviewed Original ResearchConceptsAcute kidney injuryChronic kidney diseaseKidney Precision Medicine ProjectKidney biopsyKidney diseasePrecision Medicine ProjectKidney tissueMulticenter prospective cohort studyProtocol kidney biopsiesProspective cohort studyDeep clinical phenotypingPrecision medicine approachMedicine ProjectKidney injuryClinical characteristicsCohort studyClinical outcomesSubgroup analysisMorbid diseaseNovel therapiesPreventive strategiesClinical phenotypingDisease subgroupsToxic injuryPatients
2020
Variation in Best Practice Measures in Patients With Severe Hospital-Acquired Acute Kidney Injury: A Multicenter Study
Moledina DG, Belliveau O, Yamamoto Y, Arora T, Carey KA, Churpek M, Martin M, Partridge CM, Mansour SG, Parikh CR, Koyner JL, Wilson FP. Variation in Best Practice Measures in Patients With Severe Hospital-Acquired Acute Kidney Injury: A Multicenter Study. American Journal Of Kidney Diseases 2020, 77: 547-549. PMID: 33075389, PMCID: PMC8672301, DOI: 10.1053/j.ajkd.2020.08.013.Peer-Reviewed Original Research
2018
Phenotyping of Acute Kidney Injury: Beyond Serum Creatinine
Moledina DG, Parikh CR. Phenotyping of Acute Kidney Injury: Beyond Serum Creatinine. Seminars In Nephrology 2018, 38: 3-11. PMID: 29291759, PMCID: PMC5753429, DOI: 10.1016/j.semnephrol.2017.09.002.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAcute kidney injuryKidney injuryAKI definitionSerum creatinineStructural kidney injuryGlomerular filtration rateLong-term outcomesAKI phenotypesCommon complicationHospitalized patientsFiltration rateDifferent therapiesConsensus definitionInjuryLack sensitivityMolecular pathwaysCreatinineDistinct phenotypesHeterogeneous conditionPhenotypeComplicationsPatientsPrognosisTherapyEtiology
2017
A Survey of Patient Attitudes Toward Participation in Biopsy-Based Kidney Research
Moledina DG, Cheung B, Kukova L, Luciano RL, Peixoto AJ, Wilson FP, Alfano S, Parikh CR. A Survey of Patient Attitudes Toward Participation in Biopsy-Based Kidney Research. Kidney International Reports 2017, 3: 412-416. PMID: 29725645, PMCID: PMC5932306, DOI: 10.1016/j.ekir.2017.11.008.Peer-Reviewed Original ResearchAdditional needle passesKidney tissueKidney biopsyKidney diseasePatients' attitudesNeedle passesHealth/National InstituteMultivariable logistic modelNational InstituteNovel therapeutic targetHuman kidney tissueBiopsy complicationsAfrican American participantsLower oddsBiopsyTherapeutic targetPrecision Medicine InitiativePatientsMedicine InitiativeTissueDiseaseKidney researchParticipantsAdditional burdenTotal
2015
Pharmacologic Treatment of Common Symptoms in Dialysis Patients: A Narrative Review
Moledina DG, Perry Wilson F. Pharmacologic Treatment of Common Symptoms in Dialysis Patients: A Narrative Review. Seminars In Dialysis 2015, 28: 377-383. PMID: 25913502, DOI: 10.1111/sdi.12378.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTreatment of fatigueCommon symptomsEnd-stage renal disease patientsRenal disease patientsAnabolic steroid nandroloneDisease-related symptomsEvidence-based guidelinesEfficacy of drugsPharmacologic treatmentDialysis patientsCreatine supplementationDisease patientsTreatment decisionsHemodialysis experienceReduced qualityPatientsNarrative reviewSomatic symptomsSymptomsCrampsESRDTreatmentInsomniaTherapyHeavy burden
2013
Longitudinal Predictors of Uremic Pruritus
Shirazian S, Kline M, Sakhiya V, Schanler M, Moledina D, Patel C, Hazzan A, Fishbane S. Longitudinal Predictors of Uremic Pruritus. Journal Of Renal Nutrition 2013, 23: 428-431. PMID: 24209894, DOI: 10.1053/j.jrn.2013.08.002.Peer-Reviewed Original ResearchConceptsIntact parathyroid hormoneCalcium-phosphate productParathyroid hormoneUremic pruritusSerum calciumSerum phosphateSerum phosphorusElevated serum phosphorusOriginal study groupDisorders of boneHemodialysis patientsPlacebo treatmentPruritus scoreMineral diseaseStudy groupPruritusBone indicatorsSignificant predictorsPatientsMineral statusBoneWeeksLongitudinal predictorsPredictorsCommon problem