Featured Publications
Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy
Baker ML, Yamamoto Y, Perazella MA, Dizman N, Shirali AC, Hafez N, Weinstein J, Simonov M, Testani JM, Kluger HM, Cantley LG, Parikh CR, Wilson FP, Moledina DG. Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy. Journal For ImmunoTherapy Of Cancer 2022, 10: e004421. PMID: 35354588, PMCID: PMC8968986, DOI: 10.1136/jitc-2021-004421.Peer-Reviewed Original ResearchConceptsAcute interstitial nephritisAcute kidney injuryImmune checkpoint inhibitor therapyCheckpoint inhibitor therapyICI therapyKidney injuryInhibitor therapyInterstitial nephritisTime-varying Cox proportional hazards modelsHigher peak serum creatinineSevere acute kidney injuryCancer typesCox proportional hazards modelAssociations of biopsyBaseline laboratory valuesObservational cohort studyPeak serum creatinineFavorable treatment responseProportional hazards modelAKI patientsTherapy initiationCohort studySerum creatinineUnivariable analysisImmune activation
2017
Plasma Monocyte Chemotactic Protein-1 Is Associated With Acute Kidney Injury and Death After Cardiac Operations
Moledina DG, Isguven S, McArthur E, Thiessen-Philbrook H, Garg AX, Shlipak M, Whitlock R, Kavsak PA, Coca SG, Parikh CR, Consortium T. Plasma Monocyte Chemotactic Protein-1 Is Associated With Acute Kidney Injury and Death After Cardiac Operations. The Annals Of Thoracic Surgery 2017, 104: 613-620. PMID: 28223055, PMCID: PMC5588689, DOI: 10.1016/j.athoracsur.2016.11.036.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedBiomarkersCardiac Surgical ProceduresCause of DeathChemokine CCL2FemaleFollow-Up StudiesHeart DiseasesHumansIncidenceMaleOdds RatioOntarioPostoperative ComplicationsPreoperative PeriodPrognosisProspective StudiesRisk AssessmentRisk FactorsSurvival RateUnited StatesConceptsAcute kidney injuryMCP-1 levelsRisk of deathCardiac operationsChemotactic protein-1Highest tertileKidney injuryMCP-1Plasma MCP-1 levelsSevere acute kidney injuryMonocyte chemotactic protein-1High-risk patientsIschemia-reperfusion injuryPlasma MCP-1Protein 1AKI outcomesAKI riskAdjusted riskObservational cohortPrevention strategiesPromising biomarkerBiomarker endpointsTertileInjuryTranslational research