2023
CRP Versus SAA for Identification of Inflammatory Hepatic Adenomas
Soon G, Yasir S, Jain D, Kakar S, Wu T, Yeh M, Torbenson M, Chen Z. CRP Versus SAA for Identification of Inflammatory Hepatic Adenomas. Applied Immunohistochemistry & Molecular Morphology 2023, 31: 590-595. PMID: 37698958, DOI: 10.1097/pai.0000000000001155.Peer-Reviewed Original ResearchConceptsC-reactive proteinFocal nodular hyperplasiaHepatic adenomaInflammatory hepatic adenomaInflammatory adenomasNodular hyperplasiaH-scorePositive C-reactive proteinBeta-catenin activationProportion of casesInflammatory hepatocellular adenomaGlutamine synthetase stainingComplication riskRetrospective studyResection specimensPatient managementHepatocellular adenomaImmunohistochemical stainingSerum amyloidPositive stainingControl groupAdenomasIntense stainingMolecular classificationCRP staining
2022
Hepatic Adenomas in Patients 60 and Older Are Enriched for HNF1A Inactivation and Malignant Transformation
Yasir S, Chen ZE, Jain D, Kakar S, Wu TT, Yeh MM, Torbenson MS. Hepatic Adenomas in Patients 60 and Older Are Enriched for HNF1A Inactivation and Malignant Transformation. The American Journal Of Surgical Pathology 2022, 46: 786-792. PMID: 35383587, PMCID: PMC9469468, DOI: 10.1097/pas.0000000000001892.Peer-Reviewed Original ResearchConceptsPersons 60 yearsAtypical histologic featuresHepatic adenomaMalignant transformationControl groupOlder aged personInflammatory adenomasUnclassified adenomasHistologic featuresGroups of adenomasAged personsEarly malignant transformationYears of agePersons age 60Patients 60Persons 60Lipofuscin depositionMyxoid changeAge 60AdenomasBeta-catenin activationBeta-catenin pathwayAgeWomenMore years
2021
Pediatric Hepatocellular Adenomas
Pacheco MC, Torbenson MS, Wu TT, Kakar S, Jain D, Yeh MM. Pediatric Hepatocellular Adenomas. The American Journal Of Surgical Pathology 2021, 45: 1641-1647. PMID: 34148984, PMCID: PMC8608351, DOI: 10.1097/pas.0000000000001763.Peer-Reviewed Original ResearchConceptsHepatocellular adenomaPrepubescent groupPediatric patientsNonsyndromic groupΒ-cateninAdenoma subtypesImmunohistochemical staining profileHepatocellular adenoma subtypesPostpubescent groupClinical characteristicsUnclassified subtypeClinical historySyndromic groupsImmunohistochemical stainingPatientsType adenomasAdenomasSyndromeAge groupsLarger studyStaining profileSubtypesGreater percentageGroupLanguage search
2013
Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma
Joseph NM, Ferrell LD, Jain D, Torbenson MS, Wu TT, Yeh MM, Kakar S. Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma. Modern Pathology 2013, 27: 62-72. PMID: 23807780, DOI: 10.1038/modpathol.2013.114.Peer-Reviewed Original ResearchMeSH KeywordsAdenoma, Liver CellAdolescentAdultAgedBiomarkers, TumorBiopsyChildChild, PreschoolC-Reactive ProteinDiagnosis, DifferentialDiagnostic ErrorsFemaleFocal Nodular HyperplasiaGlutamate-Ammonia LigaseHumansImmunohistochemistryInflammation MediatorsLiver NeoplasmsMaleMiddle AgedPredictive Value of TestsSerum Amyloid A ProteinYoung AdultConceptsSerum amyloid-associated proteinFocal nodular hyperplasiaAmyloid-associated proteinsInflammatory hepatocellular adenomaNodular hyperplasiaHepatocellular adenomaStaining patternDuctular reactionFibrous stromaFocal nodular hyperplasia casesMap-like patternOverlapping histological featuresGlutamine synthetase stainingHistological featuresProtein immunohistochemistryHyperplasia casesIndeterminate lesionsPositive stainingHyperplasiaDiagnostic utilityAdenomasBlood vesselsFrequent overlapStainingDiagnostic errors
2008
Narrow-band imaging without high magnification to differentiate polyps during real-time colonoscopy: improvement with experience
Rogart JN, Jain D, Siddiqui UD, Oren T, Lim J, Jamidar P, Aslanian H. Narrow-band imaging without high magnification to differentiate polyps during real-time colonoscopy: improvement with experience. Gastrointestinal Endoscopy 2008, 68: 1136-1145. PMID: 18691708, DOI: 10.1016/j.gie.2008.04.035.Peer-Reviewed Original ResearchConceptsNarrow-band imagingNonadenomatous polypsColorectal polypsSingle tertiary referral centerReal-time colonoscopyTertiary referral centerKudo pit patternLearning curvePit pattern classificationWL colonoscopyEndoscopic diagnosisColonoscopyClinical decisionDiagnostic accuracyPatientsPolypsEndoscopist performancePit patternAdenomasTotalVivoPolypectomyHistologyDifferent cytokeratin and neuronal cell adhesion molecule staining patterns in focal nodular hyperplasia and hepatic adenoma and their significance
Iyer A, Robert ME, Bifulco CB, Salem RR, Jain D. Different cytokeratin and neuronal cell adhesion molecule staining patterns in focal nodular hyperplasia and hepatic adenoma and their significance. Human Pathology 2008, 39: 1370-1377. PMID: 18602664, PMCID: PMC3738023, DOI: 10.1016/j.humpath.2008.01.015.Peer-Reviewed Original ResearchConceptsFocal nodular hyperplasiaNeuronal cell adhesion moleculeHepatic adenomaNodular hyperplasiaCell adhesion moleculeCytokeratin 7Cytokeratin 19Biliary epitheliumProgenitor/stem cellsAdhesion moleculesTelangiectatic focal nodular hyperplasiaCytokeratin 7 stainsStem cellsRare positivityAbnormal perfusionBile ductHepatocellular carcinomaStrong positivityHepatic endotheliumImmunohistochemical analysisModerate stainingFibrous septaDifferent cytokeratinsHyperplasiaAdenomas